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  • Chemistry  (13)
  • Genetic map  (2)
  • Immunohistochemistry  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Immunohistochemical localization of cytochrome P450 2E1 in human pulmonary carcinoma and normal bronchial tissue (1995)
    Springer
    Virchows Archiv 426 (1995), S. 243-247 
    Details
    ISSN: 1432-2307
    Keywords: CYP2E1 ; Immunohistochemistry ; Pulmonary carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Cytochrome P450 2E1 (CYP2E1) is a major xenobiotic-metabolizing enzyme but data concerning its extrahepatic expression are few. CYP2E1 can metabolically activate many procarcinogens and therefore its presence in the lung might play a role in bioactivation of procarcinogens, so we studied the expression and localization of CYP2E1 in primary pulmonary carcinomas and surrounding normal bronchial tissue from 28 patients. Seromucous glands showed expression of CYP2E1 in 19 and bronchial epithelium in 18 of the 28 samples of normal bronchial tissue. Thirteen of the corresponding cases of primary pulmonary carcinoma showed staining for CYP2E1. In 11 of these 13 cases, CYP2E1 was also present in normal bronchial tissue. There was no statistically significant difference in the expression of CYP2E1 between adenocarcinomas and squamous cell carcinomas. No association was observed between the expression of CYP2E1 in tumour tissue and normal bronchial tissue. However, there was a significant correlation between the expression of CYP2E1 in seromucous glands and bronchial epithelium (r=0.61, P〈0.01) of normal tissue. We conclude that CYP2E1 can be present in both normal and neoplastic bronchial tissue.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00191361
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  • 2
    Electronic Resource
    Electronic Resource
    Theobroma cacao L.: a genetic linkage map and quantitative trait loci analysis (1996)
    Springer
    Theoretical and applied genetics 93 (1996), S. 205-214 
    Details
    ISSN: 1432-2242
    Keywords: Heterozygosity ; Molecular markers ; Genetic map ; Quantitative trait loci ; Theobroma cacao
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract A genetic linkage map of Theobroma cacao (cocoa) has been constructed from 131 backcross trees derived from a cross between a single tree of the variety Catongo and an F1 tree from the cross of Catongo by Pound 12. The map comprises 138 markers: 104 RAPD loci, 32 RFLP loci and two morphologic loci. Ten linkage groups were found which cover 1068 centimorgans (cM). Only six (4%) molecular-marker loci show a significant deviation from the expected 1∶1 segregation ratio.The average distance between two adjacent markers is 8.3 cM. The final genome-size estimates based on two-point linkage data ranged from 1078 to 1112 cM for the cocoa genome. This backcross progeny segregates for two apparently single gene loci controlling (1) anthocyanidin synthesis (Anth) in seeds, leaves and flowers and (2) self-compatibility (Autoc). The Anth locus was found to be 25 cM from Autoc and two molecular markers co-segregate with Anth. The genetic linkage map was used to localize QTLs for early flowering, trunk diameter, jorquette height and ovule number in the BC1 generation using both single-point ANOVA and interval mapping. A minimum number of 2–4 QTLs (P〈0.01) involved in the genetic expression of the traits studied was detected. Coincident map locations of a QTL for jorquette height and trunk diameter suggests the possibility of pleiotropic effects in cocoa for these traits. The combined estimated effects of the different mapped QTLs explained between 11.2% and 25.8% of the phenotypic variance observed in the BC1 population.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00225747
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  • 3
    Electronic Resource
    Electronic Resource
    Theobroma cacao L.: a genetic linkage map and quantitative trait loci analysis (1996)
    Springer
    Theoretical and applied genetics 93 (1996), S. 205-214 
    Details
    ISSN: 1432-2242
    Keywords: Key words Heterozygosity ; Molecular markers ; Genetic map ; Quantitative trait loci ; Theobroma cacao
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract A genetic linkage map of Theobroma cacao (cocoa) has been constructed from 131 backcross trees derived from a cross between a single tree of the variety Catongo and an F1 tree from the cross of Catongo by Pound 12. The map comprises 138 markers: 104 RAPD loci, 32 RFLP loci and two morphologic loci. Ten linkage groups were found which cover 1068 centimorgans (cM). Only six (4%) molecular-marker loci show a significant deviation from the expected 1:1 segregation ratio.The average distance between two adjacent markers is 8.3 cM. The final genome-size estimates based on two-point linkage data ranged from 1078 to 1112 cM for the cocoa genome. This backcross progeny segregates for two apparently single gene loci controlling (1) anthocyanidin synthesis (Anth) in seeds, leaves and flowers and (2) self-compatibility (Autoc). The Anth locus was found to be 25 cM from Autoc and two molecular markers co-segregate with Anth. The genetic linkage map was used to localize QTLs for early flowering, trunk diameter, jorquette height and ovule number in the BC1 generation using both single-point ANOVA and interval mapping. A minimum number of 2–4 QTLs (P〈0.01) involved in the genetic expression of the traits studied was detected. Coincident map locations of a QTL for jorquette height and trunk diameter suggests the possibility of pleiotropic effects in cocoa for these traits. The combined estimated effects of the different mapped QTLs explained between 11.2% and 25.8% of the phenotypic variance observed in the BC1 population.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001220050267
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  • 4
    Electronic Resource
    Electronic Resource
    Demonstration of morphine in ganglion cells of the hippocampus from victims of heroin overdose by means of anti-morphine antiserum (2000)
    Springer
    International journal of legal medicine 113 (2000), S. 117-120 
    Details
    ISSN: 1437-1596
    Keywords: Key words Ganglion cells ; Hippocampus ; Immunohistochemistry ; Mean optical density (MOD) ; Morphine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Notes: Abstract To investigate the topography of morphine distribution in the human brain, a method has been developed to detect morphine immunohistochemically. In this study hippocampus tissue from victims of heroin overdose (blood morphine concentrations 220 ng/g–1500 ng/g; 6-MAM positive urine sample), known for its high concentration of μ-opiate receptors was used. The immunohistochemical staining was performed with an anti-morphine antiserum originally developed for radio-immuno-assays. In comparison with control specimens from cases of sudden death without morphine exposition or a history of heroin abuse, the brains from victims of heroin overdose showed selectively stained ganglion cells, axons and dendrites, suggesting a massive concentration of morphine in the neuronal structures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004140050012
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  • 5
    Electronic Resource
    Electronic Resource
    Beiträge zur Chemie des Bors. XVI. Dialkylamino-chloro-borane (1962)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 318 (1962), S. 293-303 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Bis(dialkylamino) boranes, (R2N)2BH, are easily prepared either by hydrogenation of the corresponding chlorides, (R2N)2BCl, by means of LiH or by transamination of [(CH3)2N]2BH. From the reaction products and two moles of HCl, dialkylammonium chlorides and the easily dimerizing dialkylamino chloroboranes, R2NB(H)Cl, are obtained. These react, in the monomeric form, with further HCl to R2NH · B(H)Cl2. In contrast with the other bis(dialkylamino)-boranes, [(CH3)2N]2BH reacts with HCl without any cleavage of the B-N bond yielding the salt [Cl(H)B(NHMe2)2]Cl.
    Notes: Bis(dialkylamino)-borane, (R2N)2BH, sind durch Hydrierung von Bis(dialkylamino)chloroboranen mit Lithiumhydrid in Äther und durch Umaminierung von Bis(dimethylamino)-boran leicht zugänglich. Bei der Umsetzung der Bis(dialkylamino)-borane mit 2 Mol HCl erhält man Dialkylaminhydrochloride und Dialkylamino-chloro-borane, R2NB(H)Cl, die sich leicht dimerisieren. An die monomeren Verbindungen lagert sich HCl zu R2NH · B(H)Cl2 an. Im Gegensatz zu den anderen Bis(dialkylamino)-boranen reagiert (Me2N)2BH mit HCl ohne Spaltung der B-N-Bindung zu dem Salz [Cl(H)B · (NHMe2)2]Cl.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19623180508
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  • 6
    Electronic Resource
    Electronic Resource
    Bar-Stickstoff-Verbindungen. XXI. Die Struktur des 1,8,10,9-Triazaboradekalins (1966)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 342 (1966), S. 297-306 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: The RAMAN spectrum and the IR spectrum in the range 500-4000 cm-1 of liquid 1,8,10,9-triazaboradecaline were recorded. Major frequencies were assigned by comparing the data with the IR spectra of the corresponding N-dideuterated and 10B-labeled derivatives and by taking into consideration the expected vibrational spectrum of the compound. In accordance with the PMR spectrum, the structure of 1,8,10,9-triazaboradecaline as a bicyclic B-N-C system was confirmed; the bonding situation is discussed briefly.
    Notes: Vom 1,8,10,9-Triazaboradekalin wurde im flüssigen Zustand das RAMAN-Spektrum und das IR-Spektrum von 500-4000 cm-1 aufgenommen. Durch Vergleich mit den IR-Spektren der entsprechenden N-dideuterierten und 10B-markierten Verbindung und Berücksichtigung des Erwartungsspektrums wird eine Zuordnung zu den Grundschwingungen durchgeführt. In Übereinstimmung mit dem 1H-Kernresonanzspektrum wird die Struktur der Verbindung als bicyclisches Bor-Stickstoff-Kohlenstoff-System bestätigt. Die Bindungsverhältnisse werden kurz diskutiert.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19663420510
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  • 7
    Electronic Resource
    Electronic Resource
    Bor-Stickstoff-Verbindungen. XXIV. Spektroskopische Untersuchungen an 1,3,2-Diazaboracycloalkanen (1966)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 344 (1966), S. 329-336 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: The infrared spectrum of 1,3,2-diazaboracyclohexane has been recorded and major absorptions were assigned. The nature of the chemical bonding in 1,3,2-diazaboracycloalkanes is discussed on the basis of spectroscopic data.
    Notes: Das Infrarot-Spektrum von 1,3,2-Diazaboracyclohexan wurde aufgenommen und die Hauptbanden zugeordnet. Die Auswertung spektroskopischer Daten von 1,3,2-Diazaboracycloalkanen erlaubt eine Diskussion der Bindungsverhältnisse der BNC-Heterocyclen.
    Additional Material: 4 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19663440513
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  • 8
    Electronic Resource
    Electronic Resource
    Beiträge zur Chemie des Bors. XXII. Darstellung und Eigenschaften einiger Alkyl-dimethylamino-borhalogenide (1963)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 324 (1963), S. 270-277 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Comproportionation of alkylborondihalides with alkyl-bis(dimethylamino)-boranes yields alkyl-dimethylamino-boronhalides, RB(X)NMe2. These dimerize more readily as the carbon chain of the alkyl groups and the size of the halogen atom decreases. The halogen atom in monomeric RB(X)NMe2 is easily replaced by other ligands.
    Notes: Alkyl-dimethylamino-borhalogenide, RB(X)NMe2, (X = Cl, Br) sind durch Komproportionierung von Alkylbordihalogeniden mit Alkyl-bis(dimethylamino)-boranen zugängig. Mit abnehmender Kettenlänge der Alkylgruppe und abnehmendem Radius des Halogens wächst die Tendenz zur Dimerisierung der monomeren Verbindungen. In diesen sind die Halogenatome leicht substituierbar.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19633240507
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  • 9
    Electronic Resource
    Electronic Resource
    Beiträge zur Chemie dea Bors. XX Zur Kenntnis von Alkyl-bis(dimethylamino)-boranen (1963)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 322 (1963), S. 297-309 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Alkyl-bis(dimethylamino) boranes can be obtained by solvolysis of alkyl boron dichlorides in dimethyl amine, or by alkylation of bis(dimethylamino)-chloro-borane with alkyl lithium. Their reactions with HCl, HBr and HJ was studied.
    Notes: Alkyl-bis(dimethylamino)((dimethylamino))borane erhält man bei der Dimethylaminolyse von Alkylbordichloriden oder bei der Alkylierung von Bis(dimethylamino)-chloroboran mit Alkyl-Lithium. Ihr Verhalten gegenüber den Halogenwasserstoffen HCl, HBr und HJ wurde untersucht.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19633220509
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  • 10
    Electronic Resource
    Electronic Resource
    Bor-Stickstoff-Verbindungen. XVIII. Die Reaktionen von α,ω-Diaminen mit Aminoboranen (1965)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 340 (1965), S. 329-336 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: The reactions of aminoboranes with 1,3-diaminopropane and 3,3′-diaminodipropylamine are described; they offer ready access to boron-carbon-nitrogen heterocycles and to borazine derivatives. The reaction paths are discussed in terms of the planar arrangement of a N—B—N grouping.
    Notes: Die Reaktionen von Aminoboranen mit 1,3-Diaminopropan und 3,3′-Diaminodipropylamin werden beschrieben. Sie bieten leichten Zugang zu Bor-Stickstoff-Kohlenstoff-Heterocyclen und zu Borazolderivaten. Die Reaktionen lassen sich an Hand der ebenen Anordnung einer N—B—N-Gruppierung diskutieren.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19653400512
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