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  • 1
    Electronic Resource
    Electronic Resource
    ATP-sensitive potassium channels counteract anoxia in neurones of the substantia nigra (1991)
    Springer
    Experimental brain research 84 (1991), S. 355-358 
    Details
    ISSN: 1432-1106
    Keywords: Substantia nigra ; Pars compacta neurones ; Cyanide ; KATP channel ; Tolbutamide ; Low threshold calcium conductance ; Parkinson's disease ; Guinea pig
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The ATP-sensitive potassium channel (KATP channel) is a unique ionophore in that it appears to reflect cell metabolism. In the brain, the highest density of binding sites for the KATP channel is the substantia nigra. To evaluate the role of the KATP channel in this key brain area for motor control, we used exposure to cyanide to lower intracellular ATP and thereby mimic anoxia and ischemia. Treatment with cyanide caused the activation of a potassium current in a sub-population of nigral neurones with distinct pharmacological and electrophysiological properties. The response to cyanide was abolished by the sulphonylurea tolbutamide, a potent blocker of the KATP channel. These results suggest that in the substantia nigra, the KATP channel plays a pivotal role in normal mechanisms of neuronal homeostasis in response to anoxia and ischaemia. The significance of these findings for our understanding of the cellular mechanisms in Parkinsonian degeneration is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00231456
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  • 2
    Electronic Resource
    Electronic Resource
    Analysis of denitrification with a completely submerged pilot-scale rotating biological contactor (1979)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 21 (1979), S. 1787-1798 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The hydraulic characteristics and the denitrifying capacity of a single-stage 0.5 m diam completely submerged rotating biological contactor were studied. A two compartment model was proposed and fitted the data obtained from pulse dye applications at two different flow rate. Denitrification rates with an influent C:N ratio at 1.5:1 proved to be independent of NO3 + NO2-N concentration. The pooled denitrification data obtained under the two different flow rates could be fitted by an Arrhenius relationship for temperature over the range of 5 to 25°C. The activation energy was 16500 cal/g-mol. A substantially higher volumetric removal capacity was observed than has previously been reported for either suspended or supported denitrifying systems.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260211007
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Determination of residual stresses in denture base polymers using the layer removal techniqueThis paper is based on a thesis submitted in partial fulfillment of the M.S. degree in Oral Sciences (K. M. Murphy), State University of New York at Buffalo, New York 14214. (1985)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 19 (1985), S. 971-980 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: In order to study the influence of residual stresses on dimensional accuracy and mechanical properties of denture bases, an experimental model was devised for measurement of residual stresses in acrylic denture base polymers. Rectangular bar coupons were cut from resin plates heat processed by conventional dental methods. They included samples which had been slow and fast cooled after polymerization and had been stored in dry and wet environments. Uniaxial residual stress distributions for each coupon were disclosed by removing layers of known thicknesses and measuring the ensuing deflection of the specimens. Coupons of a commercial acrylic resin were annealed and used as controls. ANOVA and Scheffe's test were used to compare experimental conditions at the 95% confidence level. Dry specimens exhibited residual surface compressive stresses from 0.43-0.83 MPa (62-120 psi). Water-stored specimens showed higher stress levels, 2.86-3.24 MPa (414-470 psi). Slow cooled pigmented acrylic coupons which were dry showed higher residual stresses compared with other dry but nonpigmented specimens. No significant differences were found between pigmented or clear coupons which contained moisture.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820190808
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    Paper (German National Licenses)
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