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  • 1
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Clinica Chimica Acta 156 (1986), S. 105-108 
    ISSN: 0009-8981
    Keywords: Fluoride ; Free-fluoride dialyzates ; Hemodialysis
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Clinica Chimica Acta 156 (1986), S. 315-320 
    ISSN: 0009-8981
    Keywords: Boron ; Hemodialysis ; ICP ; Strontium ; Trace elements
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 0009-8981
    Keywords: Aluminoxamine ; Desferrioxamine ; Ferrioxamine ; Hemodialysis ; Pharmacokinetics
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-2072
    Keywords: Desipramine ; Swimming test ; Acute vs repeated treatment ; Brain desipramine concentrations ; Rats ; Mice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Immobility scores in the swimming test and brain concentrations of desipramine were determined in rats and mice following repeated injection of the antidepressant versus acute administration of either a behaviorally effective or ineffective dose of the drug. Five injections (IP) of desipramine (each injection being performed at the measured T1/2 of the drug in the brain) reduced immobility scores by 30%, whereas this regimen resulted in brain drug concentrations not different from those obtained after a single, behaviorally ineffective dose of desipramine. It is suggested that the enhanced “antidepressant” response such as that frequently observed in animals after repeated injection of imipramine-like drugs does not involve accumulation of the drug in the brain.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Psychopharmacology 45 (1975), S. 197-201 
    ISSN: 1432-2072
    Keywords: Locomotor activity ; Diazepam ; Benzodiazepines ; Dexamphetamine ; Anticholinergics ; Mice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Experiments were carried out in mice to investigate the influence of diazepam (DZP) on dexamphetamine, para-chloro-N-methylamphetamine (pCMA), cocaine, morphine, trihexyphenidyl or (in MAOIs pretreated) reserpine induced motor hyperactivity. The interaction of DZP with these hyperactivities in which probably different biochemical central mechanisms are involved allows to construct a profile of action of DZP and to approach its mechanism of action. The locomotor hyperactivities induced by dexamphetamine, pCMA, morphine, cocaine were not reduced by DZP even by doses which decrease spontaneous locomotor activity; low doses of DZP enhance the hyperactivity induced by these compounds. Those induced by trihexyphenidyle or by reserpine (after MAOI) were reduced by DZP at doses which produce no decrease in spontaneous motor activity. Inasmuch as DZP at low doses potentiates the effects of 4 different substances, the results can hardly be satisfactorily explained neither by an interference of the benzodiazepine on the metabolism of the drugs or by a depression of the anxiogenic action of dexamphetamine. Even though it may be difficult to relate the antagonism of DZP on trihexyphenidyl- or on reserpine- (after MAOI) induced motor hyperactivity to the suggested anticholinergic and dopaminergic actions of DZP, these effects may partly be involved in the increase in locomotor hyperactivity induced by dexamphetamine, morphine or cocaine. The observed effect of DZP on pCMA induced locomotor hyperactivity does not support a possible antiserotonine action often suggested to explain the effects of benzodiazepines in conflict situations.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-2072
    Keywords: Food intake ; Benzodiazepines ; Barbiturates ; Meprobamate ; Rats ; Mice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Various minor tranquilizers (benzodiazepines, barbiturates and meprobamate) induced an increase in the food intake of rats or mice. Drugs were injected i.p. 30 min before testing and the amount of food consumed during 30 min was recorded. The enhanced food consumption occurred when the animals were in a novel situation, in a situation which they had previously experienced, or in their home cage, in which they were used to eating in the daytime within 30 min. Studies with two benzodiazepines showed this effect to be maximal between 10 to 30 min after injection and to disappear 4 hrs after injection. Moreover, minor tranquilizers reduce the latency before eating of rats and mice tested in a new situation. These results and the observation of anti-anxiety drugs-induced hyperphagia in satiated animals suggest that: 1. The enhanced food consumption of a non familiar food in a novel situation induced by the minor tranquilizers could hardly be related only to their anti-anxiety action. 2. The existence of some inhibitory controls (endogenous satiety in daytime or satiety after recent absorption) is not essential for the action of the minor tranquilizers. 3. An increased motivation and a disruption in the food related behavior could possibly be an explanation for all the observed effects.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Psychopharmacology 94 (1988), S. 97-102 
    ISSN: 1432-2072
    Keywords: Triiodothyroacetic acid ; Triiodothyronine ; Antidepressant activity ; Mice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Triiodothyroacetic acid (TA3) is a natural thyroid analogue which possesses some of the properties of triiodothyronine (T3). In particular, it has an inhibitory effect on the thyreotropic axis, but its peripheral effects are reduced. Given the activity of T3 on psychopharmacological models of depression in rodents, we investigated the effects of TA3 on some pharmacological and behavioral tests in mice. TA3 antagonized apomorphine- and oxotremorine-induced hypothermia, potentiated yohimbine-induced toxicity andl-5-hydroxy-tryptophan-induced head twitches, but did not affect forced swimming-induced immobility or reserpine-induced hypothermia. Thus, TA3 was effective on the same psychopharmacological tests which have previously been used to demonstrate the antidepressant-like effects of T3. Moreover, TA3 under the same experimental conditions as T3 has little effect on the metabolic clearance rate parameters, and might, therefore, be preferable to T3 for clinical use in depression.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 0025-116X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The kinetics of the thermal dehydrochlorination of PVC was investigated with respect to the initiation mechanism of the hydrogen chloride chain elimination. The constant rate of dehydrochlorination in the early stages of the dehydrochlorination process is explained by an intra-chain initiation mechanism which is a consequence of a constant amount of active sites (structural irregularities) incorporated in the chains. After an initial period, dehydrochlorination is occurring in a random way, and (or) by an inter-chain dehydrochlorination mechanism initiated by a “sudden polarization” effect between the postulated zwitterion and a meanwhile unreacted —CH2CHCl— group.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 0899-0042
    Keywords: receptor-operated calcium channel antagonist ; 1H NMR ; chiral HPLC ; calmodulin ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: 1H nuclear magnetic resonance at 360 MHz shows that SK&F 96365 (1-{β-[3-(p-methoxyphenyl)-propyloxy]-p-methoxyphenethyl}-1H- imidazole hydrochloride), an antagonist of mammalian receptor-operated calcium channels, interacts with the calcium-binding regulatory protein calmodulin (CaM). This may be inferred by a number of chemical shift changes in the spectrum of the calcium-saturated protein induced by addition of the compound. Moreover, two well-resolved singlets corresponding to the 2-proton of the SK&F 96365 imidazolium moiety are observed in the spectrum over a wide range of protein:compound ratios. Separation of rac SK&F 96365 into its two enantiomers by high-performance liquid chromatography on a cellulose tris (4-methylbenzoate) column enabled us to show that the doubling of this NMR signal in the presence of CaM is due to a propensity of the protein to distinguish between the two optical isomers of the compound.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Weinheim [u.a.] : Wiley-Blackwell
    Materials and Corrosion/Werkstoffe und Korrosion 45 (1994), S. 435-443 
    ISSN: 0947-5117
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: Werkstoffe für HF-haltige Atmosphären in einer Pyrohydrolyseanlage zur Wiederaufarbeitung von Elektrolysezellenausbruch der AluminiumherstellungFür die Planung einer Pyrohydrolyseanlage zur Wiederaufarbeitung von Elektrolysezellenausbruch der Aluminiumherstellung werden Daten zur Korrosionsbeständigkeit von Werkstoffen in HF-haltigen Umgebungen bei Temperaturen bis 1180°C benötigt. Eine durchgeführte Literaturrecherche lieferte nur begrenzte Informationen, so daß Korrosionsuntersuchungen in einer Umgebung vergleichbar der des o.g. Prozesses bei 1100°C durchgeführt werden mußten. Insgesamt wurden 22 verschiedene Werkstoffe untersucht, unter ihnen auch pulvermetallurgisch hergestellte Legierungen sowie keramische Werkstoffe. Der größte Teil dieser Werkstoffe versagte durch massive Korrosion bereits nach der relativ kurzen Versuchsdauer von 68 h. Zwei Werkstoffe zeigten Korrosionsraten in einem mehr oder weniger akzeptablen Bereich: Die Nickelbasis-Legierung Haynes no. 242 und der keramische Werkstoff SSiC. Da die Versuchsbedingungen für den denkbar ungünstigsten Fall des Anlagebetriebs stehen (Störfall durch Zusammenbruch der Primärluftversorgung), wird angenommen, daß these beiden Werkstoffe für einen längerzeitigen Einsatz im Normalbetrieb geeignet sind.
    Notes: Information was needed on materials behaviour in HF-containing atmospheres of a fluidized bed for reprocessing spent pot lining from aluminium production at temperatures of up to 1180°C. A literature search was performed but, since it was only a limited success, corrosion experiments were started at 1100°C in an environment relevant to the above-mentioned conditions. 22 different materials were tested, including powder metallurgically produced alloys and ceramic materials. Most of the materials failed after the relatively short testing time of 68 h. It was mainly two materials which showed corrosion rates of a more or less acceptable order of magnitude. These were the nickel base alloy Haynes no. 242 and the ceramic material SSiC. Since the conditions of the experiments represent the most extreme case conceivable for the plant under consideration (event of malfunction), it is assumed that these materials are suitable for longer-term operation under regular conditions.
    Additional Material: 14 Ill.
    Type of Medium: Electronic Resource
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