ISSN:
1432-2072
Keywords:
Desipramine
;
Swimming test
;
Acute vs repeated treatment
;
Brain desipramine concentrations
;
Rats
;
Mice
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Immobility scores in the swimming test and brain concentrations of desipramine were determined in rats and mice following repeated injection of the antidepressant versus acute administration of either a behaviorally effective or ineffective dose of the drug. Five injections (IP) of desipramine (each injection being performed at the measured T1/2 of the drug in the brain) reduced immobility scores by 30%, whereas this regimen resulted in brain drug concentrations not different from those obtained after a single, behaviorally ineffective dose of desipramine. It is suggested that the enhanced “antidepressant” response such as that frequently observed in animals after repeated injection of imipramine-like drugs does not involve accumulation of the drug in the brain.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00172885
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