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  • Chemistry  (74)
  • Organic Chemistry  (16)
  • Human mortality  (4)
  • United States  (4)
  • hamster  (4)
  • 1
    Electronic Resource
    Electronic Resource
    Quantitative evidence that the genetic basis of human mortality operates at the translation level: A preliminary assessment
    Amsterdam : Elsevier
    Mechanisms of Ageing and Development 64 (1992), S. 149-160 
    Details
    ISSN: 0047-6374
    Keywords: Anticodon loss theory ; Genetic triplet code ; Human mortality
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0047-6374(92)90103-K
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Periodic clustering of human disease-specific mortality distributions by shape and time position, and a new integer-based law of mortality
    Amsterdam : Elsevier
    Mechanisms of Ageing and Development 55 (1990), S. 255-291 
    Details
    ISSN: 0047-6374
    Keywords: Aging ; Disease ; Human mortality ; Parametric analysis ; Survivorship ; Weibull function
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0047-6374(90)90153-7
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Localization of estrogen receptor regulatory factor in the uterine nucleus
    Amsterdam : Elsevier
    Molecular and Cellular Endocrinology 32 (1983), S. 301-313 
    Details
    ISSN: 0303-7207
    Keywords: estrogen receptor ; hamster ; progesterone induction ; receptor inactivation ; uterus
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0303-7207(83)90090-4
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Integral differences among human survival distributions as a function of disease
    Amsterdam : Elsevier
    Mechanisms of Ageing and Development 43 (1988), S. 239-257 
    Details
    ISSN: 0047-6374
    Keywords: Aging ; Disease ; GDCP function ; Human mortality ; Survivorship ; Weibull function
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0047-6374(88)90034-6
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    An unexpected periodicity among the prevalences of human age-related, mortal diseases
    Amsterdam : Elsevier
    Mechanisms of Ageing and Development 59 (1991), S. 139-152 
    Details
    ISSN: 0047-6374
    Keywords: Age-related diseases ; Disease cohorts ; Human mortality ; Population
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0047-6374(91)90080-J
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Islet-cell regeneration in the diabetic hamster pancreas with restoration of normoglycaemia can be induced by a local growth factor(s) (1996)
    Springer
    Diabetologia 39 (1996), S. 256-262 
    Details
    ISSN: 1432-0428
    Keywords: Diabetes mellitus ; hamster ; islet regeneration ; growth factors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Partial pancreatic duct obstruction in the hamster leads to the induction of endocrine-cell differentiation and new islet formation. We prepared cytosolic extracts from the partially obstructed pancreas and identified one, which when administered i.p., produced significant increases in the incorporation of tritiated thymidine by ductular and islet cells, as well as a corresponding increase in islet mass. In this study, we evaluate the ability of this extract to reverse streptozotocin diabetes mellitus. Hamsters were treated i. p. twice daily for 7 weeks with either 0.9% NaCl (saline) (n=10) or a cytosol extract (n=10) prepared previously from partially obstructed hamster pancreata. All animals in the cytosol group survived vs only 60% of the saline group (p=0.02). Random blood glucose levels were greater than 22.2 mmol/l in 90% of the saline group vs 40% in the cytosol group (p〈0.05). Pancreatic tissue from the surviving saline animals and from persistently hyperglycaemic cytosol-treated animals, showed intra-cytoplasmic vacuolation of islet cells, a characteristic lesion of sustained hyperglycaemic states. Vacuolation was not observed in normoglycaemic extract treated animals. Islets in hyperglycaemic animals demonstrated a profound decrease or absence of immunoreactive insulin, compared to an abundance of immunoreactive beta cells in cytosol-treated animals that reverted to normoglycaemia. In this group, single cells or nests of cells stained for insulin or glucagon cells were identified in ductal epithelium in association with cells budding from the duct. Morphometric analysis of pancreata in reverted cytosol-treated animals showed a new population of small islets compared with saline controls and an increased islet mass. In summary, streptozotocin diabetes can be reversed by new islet formation induced by local pancreatic growth factors, the exact nature of which remains to be determined.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00418339
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Islet-cell regeneration in the diabetic hamster pancreas with restoration of normoglycaemia can be induced by a local growth factor(s) (1996)
    Springer
    Diabetologia 39 (1996), S. 256-262 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Diabetes mellitus ; hamster ; islet regeneration ; growth factors.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Partial pancreatic duct obstruction in the hamster leads to the induction of endocrine-cell differentiation and new islet formation. We prepared cytosolic extracts from the partially obstructed pancreas and identified one, which when administered i. p., produced significant increases in the incorporation of tritiated thymidine by ductular and islet cells, as well as a corresponding increase in islet mass. In this study, we evaluate the ability of this extract to reverse streptozotocin diabetes mellitus. Hamsters were treated i. p. twice daily for 7 weeks with either 0.9 % NaCl (saline) (n = 10) or a cytosol extract (n = 10) prepared previously from partially obstructed hamster pancreata. All animals in the cytosol group survived vs only 60 % of the saline group (p = 0.02). Random blood glucose levels were greater than 22.2 mmol/l in 90 % of the saline group vs 40 % in the cytosol group (p 〈 0.05). Pancreatic tissue from the surviving saline animals and from persistently hyperglycaemic cytosol-treated animals, showed intra-cytoplasmic vacuolation of islet cells, a characteristic lesion of sustained hyperglycaemic states. Vacuolation was not observed in normoglycaemic extract treated animals. Islets in hyperglycaemic animals demonstrated a profound decrease or absence of immunoreactive insulin, compared to an abundance of immunoreactive beta cells in cytosol-treated animals that reverted to normoglycaemia. In this group, single cells or nests of cells stained for insulin or glucagon cells were identified in ductal epithelium in association with cells budding from the duct. Morphometric analysis of pancreata in reverted cytosol-treated animals showed a new population of small islets compared with saline controls and an increased islet mass. In summary, streptozotocin diabetes can be reversed by new islet formation induced by local pancreatic growth factors, the exact nature of which remains to be determined. [Diabetologia (1996) 39: 256–262]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00418339
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  • 8
    Electronic Resource
    Electronic Resource
    Expression of Reg gene in the Syrian golden hamster pancreatic islet regeneration model (1995)
    Springer
    Diabetologia 38 (1995), S. 906-913 
    Details
    ISSN: 1432-0428
    Keywords: Reg gene ; islet neogenesis ; cellophane wrap ; hamster
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We have reported previously that cellophane wrapping of the hamster pancreas is a stimulus that leads to the induction of duct epithelial cell proliferation, followed by endocrine cell differentiation and new islet formation. Reg is a candidate gene that has been reported to be expressed in regenerating pancreatic islets, suggesting a role in islet growth. We examined Reg gene expression in the cellophane-wrap model by isolating total RNA from hamster pancreata at various times after wrapping. Northern blot analysis using a rat cDNA Reg probe showed no expression of Reg in control non-wrapped hamster pancreas, whereas a strong signal was detected in control wrapped rat pancreas. Using reverse transcription of RNA followed by polymerase chain reaction (PCR) we amplified, isolated and sequenced a 194 base pair product which showed homology to rat Reg in both control and wrapped hamster pancreas. When the PCR product was used as a probe for Northern blot analysis, no signal was detected in control non-wrapped pancreata. In contrast, a strong signal was detected 1 and 2 days after wrapping, which then returned to basal between 4 and 6 days after wrapping. A similar temporal pattern was observed using in situ hybridization to localize the Reg gene. One- and 2-day wrapped but not control pancreas expressed Reg in acinar cells, but not in islets. In conclusion, (a) Reg expression is low in the control hamster pancreas; (b) in the cellophane-wrap model of islet neogenesis, increased Reg mRNA is found within acinar tissue; (c) Reg gene may thus be involved as an acinar paracrine effector of duct cell proliferation in the initial step of islet neogenesis, but may also participate in the inflammatory response to traumatic stimuli.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400578
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    Oral contraceptive use and breast cancer risk among African-American women (1995)
    Springer
    Cancer causes & control 6 (1995), S. 321-331 
    Details
    ISSN: 1573-7225
    Keywords: Blacks ; breast carcinoma ; oral contraceptives ; United States
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Recent epidemiologic studies, most of them in predominantly White populations, have suggested that long duration of oral contraceptive (OC) use may increase the risk of breast cancer at young ages. We assessed the relationship of OC use to the risk of breast cancer in African-American women aged 25 to 59 years, using interview data from a multipurpose hospital-based case-control study. Five hundred and twenty-four cases hospitalized for invasive breast cancer were compared with 1,021 controls with nonmalignant conditions unrelated to OC use. Relative risks (RR) and 95 percent confidence intervals (CI) were estimated relative to a reference category of use for less than 12 months; potential confounders were controlled by multiple logistic regression analysis. Among women under age 45, three or more years of OC use was associated with an increased risk of breast cancer: the RR estimate was 2.8 (CI=1.5–5.0) for three to four years of use, and declined to 1.5 (CI=0.8.3.0) for 10 or more years of use. Recency and timing of use did not explain the observed association. Among women aged 45 to 59, OC use was associated with little or no increase in risk: the RR estimate for three or more years of use was 1.3 (CI=0.7–2.4). The findings add to the evidence from studies of White women and a recent study of Black women which have suggested an increased risk of breast cancer at young ages for moderate or long duration use of OCs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00051407
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    Paper (German National Licenses)
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  • 10
    Electronic Resource
    Electronic Resource
    Parental ages at birth in relation to a daughter's risk of breast cancer among female participants in the Framingham study (United States) (1995)
    Springer
    Cancer causes & control 6 (1995), S. 23-29 
    Details
    ISSN: 1573-7225
    Keywords: Breast neoplasms ; cohort study ; daughters ; maternal age ; paternal age ; United States
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Data from the Framingham Heart Study, collected in Framingham, MA (United States) during 1948–86, were used to evaluate the relation of parental age at birth to the risk of breast cancer among daughters. After 38 years of follow-up, 149 breast cancer cases occurred among 2,662 women. All but two cases were confirmed by histologic report. The rate of breast cancer increased among daughters with increasing maternal age at birth up to the mid-30s, where the rate levelled off. A similar pattern was observed with paternal age. After adjustment for other confouding factors and paternal age, the rate ratios for breast cancer in daughters whose mothers were aged 26 to 31 years and 32 or more years at their birth, relative to women whose mothers were aged 25 years or younger, were 1.5 (95 percent confidence interval [CI]=1.0–2.4) and 1.3 (CI=0.8–2.2), respectively. However, there was no longer an association between paternal age at birth and risk of breast cancer after controlling for maternal age and other risk factors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00051677
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    Paper (German National Licenses)
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