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  • Chemistry  (11)
  • Spinacia  (10)
  • Key words Bone neoplasms  (4)
  • 1
    Digitale Medien
    Digitale Medien
    The role of monovalent cations for photosynthesis of isolated intact chloroplasts (1980)
    Springer
    Planta 149 (1980), S. 170-175 
    Details
    ISSN: 1432-2048
    Schlagwort(e): Cations and photosynthesis ; Chloroplast (low-salt effects) ; Light activation (photosynthesis enzymes) ; Photosynthesis ; Spinacia
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract The role of monovalent cations in the photosynthesis of isolated intact spinach chloroplasts was investigated. When intact chloroplasts were assayed in a medium containing only low concentrations of mono- and divalent cations (about 3 mval l-1), CO2-fixation was strongly inhibited although the intactness of chloroplasts remained unchanged. Addition of K+, Rb+, or Na+ (50–100 mM) fully restored photosynthesis. Both the degree of inhibition and restoration varied with the plant material and the storage time of the chloroplasts in “low-salt” medium. In most experiments the various monovalent cations showed a different effectiveness in restoring photosynthesis of low-salt chloroplasts (K+〉Rb+〉Na+). Of the divalent cations tested, Mg2+ also restored photosynthesis, but to a lesser extent than the monovalent cations. In contrast to CO2-fixation, reduction of 3-phosphoglycerate was not ihibited under low-salt conditions. In the dark, CO2-fixation of lysed chloroplasts supplied with ATP, NADPH, and 3-phosphoglycerate strictly required the presence of Mg2+ but was independent of monovalent cations. This finding excludes a direct inactivation of Calvin cycle enzymes as a possible basis for the inhibition of photosynthesis under low-salt conditions. Light-induced alkalization of the stroma and an increase in the concentration of freely exchangeable Mg2+ in the stroma, which can be observed in normal chloroplasts, did not occur under low-salt conditions but were strongly enhanced after addition of monovalent cations (50–100 mM) or Mg2+ (20–50 mM). The relevance of a light-triggered K+/H+ exchange at the chloroplast envelope is discussed with regard to the light-induced increase in the pH and the Mg2+ concentration in the stroma, which are thought to be obligatory for light activation of Calvincycle enzymes.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00380879
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  • 2
    Digitale Medien
    Digitale Medien
    Photosynthesis under osmotic stress (1981)
    Springer
    Planta 153 (1981), S. 430-435 
    Details
    ISSN: 1432-2048
    Schlagwort(e): Chloroplast ; Photosynthesis (stress recovery) ; Protoplast ; Spinacia ; Water stress
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract The reversibility of the inhibition of photosynthetic reactions by water stress was examined with four systems of increasing complexity—stromal enzymes, intact chloroplasts, mesophyll protoplasts, and leaf slices. The inhibition of soluble chloroplast enzymes by high solute concentrations was instantly relieved when solutes were properly diluted. In contrast, photosynthesis was not restored but actually more inhibited when isolated chloroplasts exposed to hypertonic stress were transferred to conditions optimal for photosynthesis of unstressed chloroplasts. Upon transfer, chloroplast volumes increased beyond the volumes of unstressed chloroplasts, and partial envelope rupture occurred. In protoplasts and leaf slices, considerable and rapid, but incomplete restoration of photosynthesis was observed during transfer from hypertonic to isotonic conditions. Chloroplast envelopes did not rupture in situ during water uptake. It is concluded that inhibition of photosynthesis by severe water stress is at the biochemical level brought about in part by reversible inhibition of chloroplast enzymes and in part by membrane damage which requires repair mechanisms for reversibility. Both soluble enzymes and membranes appear to be affected by the increased concentration of internal solutes, which is caused by dehydration.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00394981
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  • 3
    Digitale Medien
    Digitale Medien
    Increased nitrate reductase activity in leaf tissue after application of the fungicide Kresoxim-methyl (1999)
    Springer
    Planta 207 (1999), S. 442-448 
    Details
    ISSN: 1432-2048
    Schlagwort(e): Key words: Nitrate reductase ; Respiration inhibitors ; Spinacia ; Strobilurin
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract. Spinach (Spinacia oleracea L.) leaf discs floating on buffer solution were treated with Kresoxim-methyl (KROM), an inhibitor of respiratory electron transport. In the leaf tissue, actual and maximal nitrate reductase (NR) activities, nitrite content and ATP levels were determined. In darkened leaf discs incubated without KROM (control) actual NR activity decreased to 20% after 6 h in the dark. Treatment with 10 μg ml−1 (corresponding to 32 μM) KROM totally prevented inactivation of NR in the dark and also diminished NR-protein degradation during prolonged darkness. Due to restricted nitrite reduction in darkened leaf tissues, nitrite accumulated in KROM-treated discs. Inhibition of respiration decreased ATP and increased AMP levels in KROM-treated discs. In illuminated leaf discs, NR was highly activated to 65%. Nevertheless, KROM-treatment caused an additional activation of NR (activation state 76%) in the light. Possible side-effects of KROM on nitrite reduction and photosynthesis were also checked in the leaf-disc system. Neither nitrite reduction nor photosynthesis were altered in KROM-treated discs. The extent of KROM-induced activation of NR was dependent on the applied concentration and on the pH of the external medium. The highest activation of NR was achieved at an external pH of 4.8, confirming previous results (Kaiser and Brendle-Behnisch, 1995, Planta 196: 1–6) that cytosolic acidification might play an important role in the modulation of NR activity.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s004250050503
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  • 4
    Digitale Medien
    Digitale Medien
    Acid-base-modulation of nitrate reductase in leaf tissues (1995)
    Springer
    Planta 196 (1995), S. 1-6 
    Details
    ISSN: 1432-2048
    Schlagwort(e): Acid-base loading ; Nitrate reductase ; pH regulation (intracellular) ; Protein phosphorylation ; Spinacia
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract The effect of acid or base-loading of spinach (Spinacia oleracea L.) leaf discs on the activation status of nitrate reductase (NR) in the dark and in the light was investigated. Activity of NR (NRA), measured in crude extracts of leaf discs with removed lower epidermis, which had been floating on Mes-buffer [2-(N-morpholino)ethane sulfonic acid] pH 5.2 in the dark, was at a similar low level as in whole, darkened leaves. By addition of acetate or propionic acid, butyric acid or benzoic acid, NR was activated to or beyond the light level. The pH of crude tissue extracts was decreased by 0.5–1 pH units. Tissue acidification caused an inhibition of photosynthesis and of dark CO2 fixation. The acid-induced activation of NR in vivo was largely prevented by okadaic acid, an inhibitor of Type 1 and Type 2A protein phosphatases. This indicates that acid-induced activation was mediated by protein dephosphorylation. When, on the other hand, leaf discs were illuminated on Ches-buffer (2-[ N-cyclohexylamino]ethane sulfonic acid) pH 9 in the presence of bicarbonate (80 mM), their NR was as active as in intact leaves. Addition of ammonium chloride (up to 6 mM) caused a pH increase of the tissue extract up to 0.9 pH units. At the same time NR was inactivated to the dark level. Methionine sulfoximine did not prevent the ammonium effect. Photosynthesis and dark CO2 fixation were stimulated at pH 9 by ammonium chloride (1–2· mol· m −3) and were only slightly inhibited by up to 6 mol· m−3. The modulation of NR by acid-base treatment in vivo was fully reversible. The response of the NR system to acid or base treatment is consistent with a proposed role of nitrate reduction in the cellular pH-stat. The observation also indicates that cytosolic pH changes may be involved the signal chain triggering the modulation of NR.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00193210
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  • 5
    Digitale Medien
    Digitale Medien
    Photosynthesis of isolated chloroplasts and protoplasts under osmotic stress (1981)
    Springer
    Planta 151 (1981), S. 375-380 
    Details
    ISSN: 1432-2048
    Schlagwort(e): Chloroplast volume ; Photosynthesis and chloroplast volume ; Spinacia ; Water stress
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract 1. Isolated intact spinach chloroplasts respond to changes of the sorbitol concentration of the suspending medium as near-perfect osmometers within a large range of osmotic potentials. Under isotonic conditions (π=9–10 bar), their average osmotic volume is 24 μm3 and the total volume 36 μm3. The osmotic volume can be increased to 63 μm3 by lowering the sorbitol concentration until a critical osmotic potential of π=4 bar is reached. Below that value chloroplasts rupture. Between 10 bar and 4 bar, volume changes are reversible. 2. Increasing the chloroplast volume above 24 μm3 causes inhibition of photosynthesis, with 50% inhibition occurring at an osmotic potential of π=5–6 bar. This corresponds to an osmotic volume of 45–55 μm3. Depending on the duration of hypotonic treatment, inhibition of photosynthesis is more or less reversible. 3. Between 4 and 10 bar, the chloroplast envelope exhibits a very low permeability for ferricyanide, many metabolites, and soluble stroma proteins. 4. Electron transport is not inhibited by swelling of chloroplasts. Also, the ATP/ADP-ratio remains unchanged. 5. The solute concentration in the chloroplasts appears to be optimal for photosynthesis at 10 bar. Increasing the chloroplast volume causes inhibition of photosynthesis by dilution effects.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00393294
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  • 6
    Digitale Medien
    Digitale Medien
    Vergleichende DNA-zytometrische und zytogenetische Ploidie- bestimmungen an Chondro- sarkomen und Osteosarkomen (1996)
    Springer
    Der Pathologe 17 (1996), S. 374-379 
    Details
    ISSN: 1432-1963
    Schlagwort(e): Schlüsselwörter Knochentumoren ; Chondrosarkom ; Osteosarkom ; Zytogenetik ; DNA-Zytometrie ; Ploidie ; Key words Bone neoplasms ; Chondrosarcoma ; Osteosarcoma ; Cytogenetics ; DNA-cytometry ; Ploidy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Summary 10 chondrosarcomas and 10 osteosarcomas were examined using cytogenetics and DNA-image-cytometry. Cytogenetically 6 of 10 chondrosarcomas and 4 of 10 osteosarcomas showed hyperdiploid tumorcells. By DNA-cytometry in 8 of 10 chondrosarcomas and 9 of 10 osteosarcomas hyperdiploid tumorcells resp. hyperdiploid stemlines were detected. This discrepancy reflects an in-vitro-selection depending on the different entities. In 7 aneuploid clones of chondrosarcomas the chromosomal ploidy was calculated using the relative length of the chromosomes and compared with the DNA-ploidy of the native tumor. There was a close relation between both parameters of nuclear DNA-content. The interpretation of cytogenetic results is improved using a combination of karyotypic and DNA-cytometric examination. This is particularly important for the search for relations between numeric chromosomal aberrations and morphological parameters (grading).
    Notizen: Zusammenfassung 10 Chondrosarkome und 10 Osteosarkome wurden tumorzytogenetisch und DNA-zytometrisch untersucht. Das Karyogramm erbrachte bei 6 von 10 Chondrosarkomen und bei 4 von 10 Osteosarkomen den Nachweis hyperdiploider Tumorzellklone. DNA-zytometrisch wurden am nativen Tumormaterial jedoch bei 8 von 10 Chondrosarkomen und bei 9 von 10 Osteosarkomen hyperdiploide Tumorzellen, häufig in Form eigenständiger hyperdiploider Stammlinien nachgewiesen. Diese Diskrepanz ist Ausdruck einer offenbar Entitäts-abhängigen In-vitro-Selektion. Bei insgesamt 7 aneuploiden Tumorzellklonen von Chondrosarkomen konnte die chromosomale Ploidie anhand der relativen Chromosomenlängen exakt errechnet und der zytometrisch bestimmten DNA-Ploidie gegenübergestellt werden, wobei sich eine sehr enge Abhängigkeit zwischen diesen beiden Parametern des nukleären DNA-Gehaltes ergab. Die Interpretation zytogenetischer Befunde bei Knochentumoren wird durch Kombination mit der DNA-Zytometrie verbessert. Dies ist besonders dann wichtig, wenn Zusammenhänge zwischen numerischen chromosomalen Aberrationen und morphologischen Parametern (z. B. Grading) dargestellt werden sollen.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002920050175
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  • 7
    Digitale Medien
    Digitale Medien
    Therapie-induzierte Veränderungen an Osteosarkomen nach neoadjuvanter Chemotherapie (Therapiestudie COSS 86) Beziehungen zwischen morphologischen Befunden und klinischem Verlauf (1996)
    Springer
    Der Pathologe 17 (1996), S. 35-43 
    Details
    ISSN: 1432-1963
    Schlagwort(e): Schlüsselwörter Knochentumoren ; Osteosarkom ; Neoadjuvante Chemotherapie ; Regressionsgrad ; Histologische Typisierung ; Tumorgröße ; Key words Bone neoplasms ; Osteosarcoma ; Neoadjuvant chemotherapy ; Degree of regression ; Histological typing ; Tumor size
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Summary 207 osteosarcomas were examined morphologically after neoadjuvant chemotherapy according to the COSS-86 protocol using representative slides of one whole tumor plane. The rate of responders 63 %. In relapse-free patients both the whole tumors and the vital areas there of were smaller than in patients with relapse during a follow-up period of 5 years. Within the subgroup of osteoblastic osteosarcomas, metastases were observed following smaller tumors than in chondroblastic osteosarcomas. Therefore, in addition to degree of regression, histological subtype and tumor size should be considered in the prognostic evaluation of osteosarcomas.
    Notizen: Zusammenfassung Im Rahmen der kooperativen Osteosarkomstudie (COSS 86) wurden 207 Resektionspräparate von Osteosarkomen anhand der Auswertung einer Gesamttumorebene zur Bestimmung des Regressionsgrads morphologisch untersucht. Innerhalb der protokollgerecht auswertbaren Fälle betrug das Verhältnis zwischen Respondern und Nonrespondern 63 % : 37 %. Relapse-freie Patienten wiesen zum Zeitpunkt der Resektion einen kleineren Gesamttumor und geringere vitale Tumoranteile auf als Patienten mit einem metastasierenden Verlauf. Bei Berücksichtigung des histologischen Subtyps traten metastasierende Verläufe innerhalb einer Nachbeobachtungszeit von mindestens 5 Jahren in der Gruppe der osteoblastischen Osteosarkome bereits bei einer niedrigeren Gesamttumorgröße auf als bei den chondroblastischen Osteosarkomen. Bei der prognostischen Einschätzung von Osteosarkomen sollten deshalb neben dem Regressionsgrad als Parameter für das Ansprechen auf die Chemotherapie auch der histologische Aufbau und die Gesamttumorgröße Beachtung finden.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002920050132
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  • 8
    Digitale Medien
    Digitale Medien
    DNA-Zytometrie an solitären und aneurysmatischen Knochen- zysten sowie niedrigmalignen und hochmalignen zentralen Osteosarkomen Gegenwärtige Bedeutung im Rahmen der morphologischen Diagnostik intraossärer zystischer und osteoblastischer Läsionen (1996)
    Springer
    Der Pathologe 17 (1996), S. 44-49 
    Details
    ISSN: 1432-1963
    Schlagwort(e): Schlüsselwörter Knochentumoren ; Solitäre Knochenzyste ; Aneurysmatische Knochenzyste ; Niedrigmalignes zentrales Osteosarkom ; Hochmalignes zentrales Osteosarkom ; DNA-Imagezytometrie ; DNA-Aneuploidie ; Key words Bone neoplasms ; Solitary bone cyst ; Aneurysmal bone cyst ; Low-grade central osteosarcoma ; High-grade central osteosarcoma ; DNA image cytometry ; DNA aneuploidy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Summary DNA cytometric investigations of intraosseous cystic lesions and osteoblastic tumors may be helpful in morphological diagnosis. The detection of a DNA-aneuploid stemline supports the diagnosis of a high-grade malignant bone neoplasm, even in small biopsies. Solitary and aneurysmal bone cysts have DNA-diploid cell populations. Low-grade central osteosarcomas may show single-cell aneuploidies of varying extent as well as a DNA-diploid stemline. Their presence may be a sign of genetic instability within the population of neoplastic cells before a DNA-aneuploid stemline is established and should prompt careful postoperative observation.
    Notizen: Zusammenfassung DNA-zytometrische Untersuchungen intraossärer zystischer Läsionen und osteoblastischer Tumoren können die morphologische Diagnostik unterstützen. Der Nachweis von DNA-aneuploiden Tumorzellstammlinien trägt zur Sicherung der Diagnose eines hochmalignen Knochentumors auch an kleinen Biopsien bei. Solitäre und aneurysmatische Knochenzysten weisen DNA-diploide Zellpopulationen auf. Bei zentralen niedrigmalignen Osteosarkomen können neben einer diploiden Stammlinie Einzelzellaneuploidien unterschiedlichen Ausmaßes vorkommen. Ihr Auftreten kann bereits ein Hinweis auf eine genetische Instabilität innerhalb der Tumorzellpopulation sein, bevor es zur Ausprägung einer DNA-aneuploiden Stammlinie kommt und sollte bei differentialdiagnostisch schwierigen Fällen intraossärer Läsionen zu sorgfältiger Nachbeobachtung Anlaß sein.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002920050133
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  • 9
    Digitale Medien
    Digitale Medien
    Solitäre Knochenzysten Morphologische Variationsbreite, Lokalisation, Häufigkeit und Differentialdiagnose (1996)
    Springer
    Der Pathologe 17 (1996), S. 63-67 
    Details
    ISSN: 1432-1963
    Schlagwort(e): Schlüsselwörter Knochentumoren ; Solitäre Knochenzyste ; Histologie ; Key words Bone neoplasms ; Solitary bone cyst ; Histology
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Summary Analysis of 402 solitary bone cysts demonstrates the wide morphological variation of this cystic lesion with regard to histology and radiology. Aside from metaphyseal location in femur (33 %) and humerus (23 %), solitary bone cysts are also often located in calcaneus (11 %), tibia (11 %) and pelvis (10 %). Most patients are in the second decade of life. Differentiation between this benign lesion and malignant bone tumors is very important in daily clinical routine. The diagnosis cannot be based solely on radiological findings because of the variation of solitary bone cysts and the special forms, such as calcifying solitary bone cyst. Therefore, exact histological diagnosis is of particular importance.
    Notizen: Zusammenfassung Anhand von 402 solitären Knochenzysten wird die große morphologische Variationsbreite dieser zystischen Läsionen in Histologie und Radiologie dargestellt. Neben der metaphysären Lage in Femur (33 %) und Humerus (23 %), stellen Kalkaneus (11 %), Tibia (11 %) und Becken (10 %) weitere häufige Lokalisationen solitärer Knochenzysten dar. Betroffen sind überwiegend Jugendliche in der 2. Lebensdekade. Die Abgrenzung dieser benignen Läsion gegenüber malignen Knochentumoren ist im klinischen Alltag besonders wichtig. Durch die radiologische Polymorphie der solitären Knochenzyste und ihre Sonderformen, wie die kalzifizierende solitäre Knochenzyste, ist die korrekte Diagnose allein klinisch nicht eindeutig zu stellen. Der exakten histologischen Diagnostik kommt damit besondere Bedeutung zu.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002920050136
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  • 10
    Digitale Medien
    Digitale Medien
    Photosynthesis under osmotic stress (1981)
    Springer
    Planta 153 (1981), S. 423-429 
    Details
    ISSN: 1432-2048
    Schlagwort(e): Chloroplast envelope (permeability) ; Chloroplast stroma enzymes ; Spinacia ; Water stress
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract 1. Increasing the sorbitol concentration in a suspension of intact chloroplasts induced a fast, transient and not very specific efflux of metabolites from chloroplasts to the medium. Stroma proteins were retained by the chloroplasts. 2. Within the first 30 s following hypertonic stress, the chloroplast volume decreased according to the Boyle-Mariotte relation. A subsequent and transient increase suggested some influx of external solute. 3. Dark reactions of intact chloroplasts such as starch degradation and formation of labelled 3-phosphoglycerate from dihydroxyacetone phosphate or ribose-5-phosphate and 14CO2 were inhibited at low water potentials. After chloroplast rupture, the activity of stromal enzymes was decreased by high solute concentrations. Ribulose bisphosphate carboxylase exhibited a decrease of Vmax, while KmCO 2 remained unaltered. With sorbitol, sucrose, glycerol or glycinebetaine, 50% inhibition of enzymes was observed at osmotic potentials between 40 and 50 bar, with ethyleneglycol at about 70 bar. With salts such as KCl, 50% inhibition was found at 15 to 20 bar. 4. A comparison between inhibition of photosynthesis in intact chloroplasts and inhibition of enzymes in stroma extracts by solutes supports the notion that inhibition of photosynthesis at high osmotic potentials is mainly a solute effect. Another factor contributing to inhibition of photosynthesis in isolated chloroplasts is the loss of intermediates and cofactors which occurs during rapid osmotic dehydration.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00394980
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