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  • 1
    Electronic Resource
    Electronic Resource
    Isolation of an anorexigenic protein from membranes (1989)
    Springer
    Molecular and cellular biochemistry 91 (1989), S. 117-122 
    Details
    ISSN: 1573-4919
    Keywords: anorexia ; membrane protein ; anorectic substance ; erythrocyte
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract Satiety means an internal state that leads to termination of eating. We have isolated an anorexigenic glycoprotein (MW 50,000 dalton) from human and rat erythrocyte membrane and from rat liver plasma membrane. The substance isolated from all these membrane sources has almost same onset and offset anorectic effect in rats deprived of food for 96 h as well as in normally fed rats without any rebound. Similar properties of membrane anorectic substance and plasma satietin indicated that it has membrane origin. The results also suggest that the loss of appetite in chronic diseases involving damage or turn-over of cell membranes could be due to release of a glycopeptide from cellular membranes into the circulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00228086
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  • 2
    Electronic Resource
    Electronic Resource
    A novel plant membrane proteoglycan which causes anorexia in animals (1993)
    Springer
    Molecular and cellular biochemistry 120 (1993), S. 111-117 
    Details
    ISSN: 1573-4919
    Keywords: membrane ; proteoglycan ; anorexia ; hunger and satiety ; plant sprout
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract Hunger and satiety are complex interplay of several factors in human and animal species. Reduced food intake has also been observed under various pathological conditions. Earlier, we have been able to isolate an endogenous glycoprotein from erythrocyte membranes, which causes anorexia in rats. In the present study, a similar anorexigenic proteoglycan from Mung bean sprout membranes has been isolated and purified. The proteoglycan (50 kDa) consisted of 70–85% carbohydrate with galactose, glucose galactosamine and mannose as the main sugars. Protein part on analysis showed higher glutamic acid and serine content. This proteoglycan reduces food intake when injected in rats deprived of food for 96 hr as well as normally fed rats, mice and rabbits without any rebound. The TCA-soluble proteoglycan from different plant sources have also been compared for their anorexigenic activity. The similarities observed among plant and animal cell membrane proteoglycans with satietins isolated from human blood plasma could be due to membrane origin of satietins. (Mol Cell Biochem120: 111–117, 1993)
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00926083
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  • 3
    Electronic Resource
    Electronic Resource
    Studies on chemical resistance of polyesters (1988)
    Weinheim : Wiley-Blackwell
    Angewandte Makromolekulare Chemie 156 (1988), S. 21-27 
    Details
    ISSN: 0003-3146
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: Es wurden Polyester basierend auf 1,4,5,6,7,7-Hexachlor-5-norbornen-2,3-dicarbonällureanhydrid (I), Tetrachlorphthalsäureanhydrid (II), Dibromneopentylglykol (II), ein Polyesterblend (V) bestehend aus dem Polyester (III) und einem Polyester (IV) für allgemeine Zwecke, ein Polyester (VI) basierend auf 1,4,5,6,7,7-Hexachlor-5-norbornen-2,3-dicarbonsäureanhydrid und dem Polyester III und ein Polyesterblend (VII) bestehend aus den Polyestern I und III hergestellt. Ihre chemische Resistenz und ihre Feuchtigkeitsaufnahme bei Temperaturen von 25 und 65°C wurden in Säuren, 20% NaOH und Wasser untersucht. Hierbei wurde gefunden, daß der Polyester (III) von den Säuren am wenigsten angegriffen wird. Verglichen mit unbehandelten Poly meren fand bei beiden Temperaturen in 20% NaOH eine Gewichtsabnahme bei allen Polyestern statt, mit Ausnahme des Polyesters VII. Erne Gewichtszunahme aller Polyester wurde beobachtet durch Feuchtigkeitsaufnahme sowohl bei 25 als auch bei 65°C, wobei die Zunahme bei der höheren Temperatur größer war. Der Polyester III zeigte die geringste Feuchtigkeitsaufnahme.
    Notes: Chlorendic anhydride based polyester (I,) tetrachlorophthalic anhydride based polyester (II), dibromoneopentyl glycol based polyester (III,) general purpose polyester (IV,) blend of dibromoneopentyl glycol based polyester with general purpose polyester (V,) chlorendic anhydride and dibromoneopentyl glycol based polyester (VI), and a blend of chlorendic anhydride based polyester and dibromoneopentyl glycol based polyester (VII) were prepared and their chemical resistance and moisture absorption studied in various reagents, acid, alkali, and water, at 25 and 65°C. It is found that the polyester (III) is the least affected in the presence of the acids. In 20% NaOH, there was a decrease in weight for all polyesters at both the temperatures compared to the control except the polyester (VII). Increase in weight of all the polyesters was observed during the absorption of moisture both at 25 and 65°C. The increase was higher at higher temperature. Polyester (III) thus shows the least absorption of moisture.
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/apmc.1988.051560102
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  • 4
    Electronic Resource
    Electronic Resource
    O/NMe2 exchange in the reaction of 4-benzylidene-5-oxazolones with phosphorous tris(dimethylamide) (1988)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 121 (1988), S. 2067-2069 
    Details
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: 4-Benzylidene-5-oxazolones 5 do not react with P(OMe)3; with P(NMe2)3 they give rise to 4-α-[bis(dimethylamino)phosphoryl]benzyl-5-dimethylaminooxazoles 6. This behavior differs from that of the corresponding pyrazolones and isoxazolones and is attributed to a decreased stability of the dipolar adduct resulting from a β attack of phosphorus.
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19881211128
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  • 5
    Electronic Resource
    Electronic Resource
    2-Phosphaindolizines (1991)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 124 (1991), S. 475-480 
    Details
    ISSN: 0009-2940
    Keywords: 1,3-Azaphosphole, annulation to pyridine ; 2-Phosphaindolizines ; Pyridinium bromides, 1,2-dialkyl ; Phosphorus(III) chloride, condensation with CH2 groups ; Calculations, MNDO ; Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19911240309
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  • 6
    Electronic Resource
    Electronic Resource
    1,4,2-Diazaphospholothiazoles and -pyridines by a Hantzsch-Type Condensation Using Chloromethyldichlorophosphane (1995)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 128 (1995), S. 581-587 
    Details
    ISSN: 0009-2940
    Keywords: Anellated azaphospholes ; Hantzsch-type [3 + 2] cyclocondensation ; Chloromethyldichlorophosphane ; Regioselectivity ; 31P-, 1H-, 13C-NMR spectra ; Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The [3 + 2] cyclocondensation of 2-amino-1,3-thiazoline, 2-aminopyridines, 2- and 4-aminopyrimidines, 2-aminopyrazine, and 2-aminoquinoline with chloromethyldichlorophosphane in the presence of triethylamine yields regiospecifically 5,6-dihydrothiazolo[2,3-e][1,4,2]diazaphosphole (3), 1,4,2-diazaphospholo[4,5-α]pyridines (12), 1,4,2-diazaphospholo[4,5-α]pyrimidines (15), 1,4,2-diazaphospholo[4,5-e]pyrimidine (17), 1,4,2-diazaphospholo[4,5-α]pyrazine (19), and [1,4,2]diazaphospholo[4,5-α]quinoline (22), respectively. Using 2-amino-1,3-thiazole (4) and 2-aminobenzothiazoles 8, we obtained mixtures of the 1,5- and 4,5-anellated 1,4,2-diazaphospholes 5/6, 9a/10a and 9b/10b, while in the case of the methyl derivative 8c only the [1,4,2]diazaphospholo[5,4-b][1,3]benzothiazole 10c was formed. In the reaction of 2-aminothiazole and 2-aminopyrazine with Chloromethyldichlorophosphane the bis(diazaphospholo)-substituted chloromethylphosphanes 7 and 20 could be detected. The new anellated 1,4,2-diazaphospholes are colorless to pale yellow crystalline moisture-sensitive solids.
    Additional Material: 6 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19951280610
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  • 7
    Electronic Resource
    Electronic Resource
    Octa-, Hexa-, and Tetracoordination in Tin(IV) Derivatives of cis-β-(Methylthio)stilbene-α-thiol (1993)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 126 (1993), S. 2367-2371 
    Details
    ISSN: 0009-2940
    Keywords: Tin, (alkylthio)stilbene complexes of ; cis-stilbene-α-thiol, β-(methylthio)-, tin(IV) complexes of ; Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The S-methyl-cis-stilbene-α,β-dithiolate of Sn(IV), Sn[Ph(S)C=C(SCH3)Ph]4, has an octacoordinate structure with two sets of four covalent and coordinate Sn-S and Sn-S(CH3) bonds of 2.425(3) and 3.599(3) Å, respectively. Both types of Sn-S bonds are close to being tetrahedral, the coordination geometry is a distorted cube. This unprecedented structure appears to involve conventional covalent and outer-sphere coordinative Sn-S bonds. In the diphenyl derivative Ph2Sn[Ph(S)C=C(SCH3)Ph]2 the SnC2S2 core formed by the covalent Sn-C and Sn-S(thiolato) bonds is tetrahedral, but two coordinate outer-sphere Sn-S(CH3) bonds of 3.500(3) Å are also present. In the related SnCl2[Ph(S)C=C(SCH3)Ph]2 the presence of the polar Sn-Cl bonds prevents outer-sphere bonding; the coordination geometry is distorted octahedral. In the triphenyltin derivative Ph3Sn[Ph(S)C=C(SCH3)Ph] the coordination geometry is tetrahedral, the thiol-thioether ligand being monodentate with the SCH3 group in a non-interactive position.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19931261103
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  • 8
    Electronic Resource
    Electronic Resource
    Complexes of Azaphospholes: Synthesis and Structure of Pentacarbonyl-(η1)-2-phosphaindolizine)chromium(0), -molybdenum(0), and -tungsten(0) (1998)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 1998 (1998), S. 1079-1086 
    Details
    ISSN: 1434-1948
    Keywords: Phosphorus heterocycles ; P ligands ; Transition metals ; Carbonyl complexes ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The complex chemical behaviour of 2-phosphaindolizines 1 (1,3-azaphospholo[1,5-a]pyridines) towards metal carbonyl compounds was studied. (η1-2-Phosphaindolizine)M(CO)5 complexes 2-4 (M = Cr, Mo, W) were formed from 1 and [(THF)M(CO)5], the cis-L2Cr(CO)4 complex 5f from 1f and tetracarbonyl(norbornadiene) chromium(0). The reaction of 2-phosphaindolizines 1e, 1f, or 1g with tricarbonyl(cycloheptatriene)molybdenum(0) or tricarbonyl(mesitylene)tungsten(0) yielded σ-complexes of the types L2M(CO)4or L3M(CO)3 rather than isolable π-complexes. In one case a strong upfield signal (δ31P = 6.1) was observed with a coordination shift of Δδ = -161.7, which is typical for π-coordination. Prolonged reaction or work-up led, however, to dismutation yielding 1g and the fac-L3Mo(CO)3 complex 6g. X-ray structure analysis of 2a indicates an increased 10π-delocalization compared with 1a and a changed conformation of the acyl substituent. The influence of substituents and metals on the 31P and 13C complexation chemical shifts and coupling constants is discussed.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    1,4-Reductive Addition of Hydrazoic Acid to γ-Oxo-α,β-unsaturated δ-Lactones and -Lactams: A Convenient Route to α-Amino-γ-oxo-α,β-unsaturated δ-Lactones and -Lactams (1999)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1999 (1999), S. 1449-1453 
    Details
    ISSN: 1434-193X
    Keywords: Oxo enamines ; Reductive addition ; Hydrazoic acid ; δ-Lactones ; δ-Lactams ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: -γ-Oxo-α,β-unsaturated δ-lactones and lactams, which are easily accessible from their corresponding 2-furylcarbinols, were used as substrates for the 1,4-reductive addition of hydrazoic acid. The outcome of the reaction is the formation, in high yields, of the corresponding α-amino-γ-oxo-α,β-unsaturated δ-lactones and -lactams, compounds of great biological and synthetic interest.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Substitution of 2-phosphaindolizines by bromine and by chlorophosphines (1992)
    New York, NY [u.a.] : Wiley-Blackwell
    Heteroatom Chemistry 3 (1992), S. 359-366 
    Details
    ISSN: 1042-7163
    Keywords: Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Bromine does not add to phosphorus in a 2-phosphaindolizine 1 but substitutes its 1-position. The 1-bromo derivatives 2 are best prepared with Br2/NEt3 or N-bromosuccinimide. Their hydrolysis is remarkable; it involves a debromination of C-1, an oxidation of P and a selective opening of the P/C-3 bond.PCl3 also causes a substitution of the 1-position. The resulting 1-dichlorophosphino derivatives 5 easily undergo a substituent exchange at the exocyclic phosphorus. More 1-phosphino derivatives are formed in the reaction of 1 with phenyl and diazaphospholyl dichlorophosphine.
    Additional Material: 4 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hc.520030409
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