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  • Chemistry  (14)
  • phenprocoumon  (3)
  • biliary excretion  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Biliary excretion of phenprocoumon and metabolites (1988)
    Springer
    European journal of clinical pharmacology 35 (1988), S. 433-436 
    Details
    ISSN: 1432-1041
    Keywords: phenprocoumon ; biliary excretion ; metabolites ; treatment ; patients
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary To evaluate phenprocoumon elimination its possible biliary excretion was evaluated in addition to the known pathway of renal elimination. Bile samples were obtained during diagnostic endoscopy in patients receiving chronic phenprocoumon therapy and were analyzed for phenprocoumon and its metabolites by HPLC and GC-MS. The following substances were detected, mainly in conjugated form: unchanged phenprocoumon and the metabolites 7-hydroxy-, 4'-hydroxy-, and 6-hydroxy-phenprocoumon. The data provide direct evidence of the biliary elimination of unchanged phenprocoumon and its metabolites in humans.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00561379
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  • 2
    Electronic Resource
    Electronic Resource
    Lack of effect of cimetidine on action of phenprocoumon (1982)
    Springer
    European journal of clinical pharmacology 23 (1982), S. 365-367 
    Details
    ISSN: 1432-1041
    Keywords: cimetidine ; phenprocoumon ; warfarine ; drug metabolism interaction ; histamine receptor antagonist ; anticoagulation ; bleeding complication
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In patients on oral warfarin, nicoumalone and phenindione an increase in the anticoagulant effect has been described during concomitant treatment with cimetidine. Therefore the effect of cimetidine on the steady state dynamics of phenprocoumon has been investigated in ten outpatients. No change in the anticoagulant effect of phenprocoumon was observed during or after two weeks on cimetidine, as measured by the thrombotest coagulation method, prothrombin time, fibrinopeptide A concentration and plasma phenprocoumon level. The data show that cimetidine does not interact with the metabolism of phenprocoumon in contrast to warfarin. Thus, phenprocoumon maintenance therapy when combined with concomitant cimetidine treatment can be considered not to carry an increased risk of haemorrhagic complications.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00613622
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Elimination of azlocillin in patients with biliary t-tube drainage (1982)
    Springer
    European journal of clinical pharmacology 22 (1982), S. 435-439 
    Details
    ISSN: 1432-1041
    Keywords: azlocillin ; kinetics ; biliary excretion ; liver dysfunction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetic of azlocillin was followed in five elderly patients after biliary surgery. Total clearance was 138.6±17.7 ml/min when 2.0 g was given as an i.v. bolus injection. The half-life of the β-phase averaged 110 min. The total clearance and the half-life of azlocillin were influenced by slight impairment of renal function (creatinine clearance 59.4±13.6 ml/min). In patients with normal liver function biliary excretion of the drug amounted to 5.3±2.8% of the dose (n=3) and the kinetics of biliary excretion were linear. In contrast, in two patients with impaired liver function biliary excretion was 0.2% and 0.5% of the dose, and kinetic analysis of biliary excretion rates revealed at least one zero order step in the excretion process. Renal excretion of the drug amounted to 45.0±17.7% of the dose, which means that 50% of the total clearance of azlocillin has to be accounted for by metabolic clearance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542549
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  • 4
    Electronic Resource
    Electronic Resource
    Effect of cholestyramine on the gastrointestinal absorption of phenprocoumon and acetylosalicylic acid in man (1972)
    Springer
    European journal of clinical pharmacology 4 (1972), S. 142-145 
    Details
    ISSN: 1432-1041
    Keywords: Cholestyramine ; interaction with absorption ; phenprocoumon ; acetylosalicylic acid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of cholestyramine on the absorption of phenprocoumon and acetylosalicylic acid has been studied in volunteers by comparing their serum concentrations after a single oral dose either of the drug alone or simultaneously with the resin in a crossover repetition arrangement. In four volunteers cholestyramine 8 g significantly reduced the absorption of a simultaneous 15 mg dose of phenprocoumon. The effect of the latter on coagulation, as measured by the thrombotest method was also diminished. The absorption of acetylosalicylic acid 500 mg was delayed by cholestyramine but there was no appreciable effect on the total amount absorbed. These results are in accordance with the stronger binding of phenprocoumon to cholestyramine inin vitro experiments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00561136
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  • 5
    Electronic Resource
    Electronic Resource
    Chronik (1989)
    Weinheim : Wiley-Blackwell
    Chemie in unserer Zeit 23 (1989), S. 210-214 
    Details
    ISSN: 0009-2851
    Keywords: Chemistry ; Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ciuz.19890230606
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  • 6
    Electronic Resource
    Electronic Resource
    Messung der Stömungsdoppelbrechung bei grosser Apparatendoppelbrechung (1941)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 24 (1941), S. 278-288 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19410240140
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Schädigung der Z-Gruppe und Hydantoinbildung bei der Alkalischen Verseifung von Z-Peptidestern (1985)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 327 (1985), S. 479-486 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Cleavage of Z-Group and Formation of Hydantoine during Saponification of Z-Peptide EstersIn the course of alkaline decomposition of the tetrapeptide ester Z-Arg(NO2)-Gly-Phe-Phe-OMe one gets a high output of a by-product. the latter was isolated and identified by 13C-n.m.r. spectroscopy to be the hydantoine derivative arising from a loss of Z-group and from a cyclisation. A possibility to suppress the undesired side-reaction by addition of benzylalcohol is proposed resulting from the discussion of a probable mechanism of reaction.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19853270315
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  • 8
    Electronic Resource
    Electronic Resource
    Neue makrocyclische Wirte für den Einschluß von organischen Gastmolekülen - Kristallstruktur eines Komplexes mit Dimethylformamid (1 : 1) (1993)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 335 (1993), S. 235-243 
    Details
    ISSN: 0941-1216
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: New Macrocyclic Hosts for the Inclusion of Organic Guest Molecules - Crystal Structure of a Complex with Dimethylformamide (1 : 1)New pyridino crowns with amide and sulfonamide groups 1b and 1c are synthesized. They form numerous stoichiometric crystalline inclusion complexes with alcohols, various dipolar-aprotic solvents, as well as cyclic ethers. Host-guest stoichiometries are discussed and inclusion selectivities (relating to DMF) are shown. The structure of the crystalline DMF inclusion compound of the sulfonamide host 1c (1 : 1) is determined by X-ray diffraction, showing a lattice void inclusion mode.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19933350305
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    Benzo condensed crown ethers containing 1,8-naphthyridine or 4-pyridone units - synthesis and complex formation with organic guest molecules (1995)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 337 (1995), S. 451-455 
    Details
    ISSN: 0941-1216
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: New crown compounds 3-5 comprising beside ophenylene groups 1,8-naphthyridine or 4-pyridone groups as characteristic building units are synthesized. They form numerous stoichiometric crystalline complexes with uncharged organic molecules including alcohols, nitro compounds and other dipolar-aprotic solvents, as well as cyclic ethers and aromatic hydrocarbons. Properties of complex formation and host-guest stoichiometries are discussed making a comparison with parent host analogues.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19953370198
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  • 10
    Electronic Resource
    Electronic Resource
    Crystalline diol hosts featuring a bulky biphenyl framework - Host Synthesis and Formation of Inclusion Compounds (1996)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 338 (1996), S. 553-557 
    Details
    ISSN: 0941-1216
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Biphenyls having two hydroxy containing benzo condensed oligocyclic substituents in positions 2,2′ were synthesized to yield the crowded diols 5 - 10. These compounds proved successful clathrate hosts. Crystalline inclusion formation is reported and discussed with reference to structural parameters of the host molecules covering the bis-fluorenol analogous host compounds 1-4.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.199633801104
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