ZIB

Hits per page

hits 1 - 2 | 2 hits

Sorting

Electronic Resource

The Light Green Cells ofLymnaea: A neuroendocrine model system for stimulus-induced expression of multiple peptide genes in a single cell type (1992)

Geraerts, W. P. M. ; Smit, A. B. ; Li, K. W. ; [et al.]

Springer

Cellular and molecular life sciences 48 (1992), S. 464-473

add to mindlist on the mindlist

Details

ISSN: 1420-9071

Keywords: Molluscan insulin-related peptides ; schistosomin ; neuropeptide gene family ; generation of neuropeptide diversity ; stimulus-dependent expression ; information-handling capacity ; evolution

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Abstract We review recent experiments showing that the cerebral neuroendocrine Light Green Cells (LGCs) of the freshwater snail,Lymnaea stagnalis, express a family of distinct though related molluscan insulin-related peptide (MIP) genes. The LGCs are involved in the regulation of a wide range of interrelated life processes associated with growth, (energy) metabolism and reproduction. We consider the mechanism of generation of diversity among MIPs, and present evidence that conditions with distinct effects on growth, metabolism and reproduction also can induce distinct patterns of expression of the MIP and schistosomin genes. The stimulus-dependent expression of multiple neuropeptide genes enormously increases the adaptive potential of a peptidergic neuron. We suggest that this contributes significantly to the information-handling capacity of the brain.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01928165

Permalink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

Electronic Resource

Direct peptide profiling of single neurons by matrix-assisted laser desorption-ionization mass spectrometry (1993)

van Veelen, P. A. ; Jiménez, C. R. ; Li, K. W. ; [et al.]

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 28 (1993), S. 1542-1546

add to mindlist on the mindlist

Details

ISSN: 0030-493X

Keywords: Chemistry ; Analytical Chemistry and Spectroscopy

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: Peptide profiles of single neurons in Lymnaea stagnalis were directly characterized by matrix-assisted laser desorption-ionization mass spectrometry. The mass analysis was performed after minor pretreatment and without any separation steps. Good-quality spectra were obtained of several cell types and also other tissues. The results were compared with the results of conventional peptide chemical methods. In addition to many known peptides, several new peptides were identified. The method provides new opportunities for studying peptide compositions at the single-cell level, which is shown to have many advantages.

Additional Material: 5 Ill.