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  • 1
    Electronic Resource
    Electronic Resource
    Zweimaliges toxisches Schocksyndrom Superantigene als gemeinsamer Nenner? (1998)
    Springer
    Monatsschrift Kinderheilkunde 146 (1998), S. 117-120 
    Details
    ISSN: 1433-0474
    Keywords: Schlüsselwörter Toxisches Schocksyndrom ; Juvenile chronische Arthritis ; Superantigen ; Mycoplasma hominis ; Key words Toxic shock syndrome ; Juvenile rheumatoid arthritis ; Superantigen ; Mycoplasma hominis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary A sixteen year old girl with juvenile rheumatoid arthritis suffered two episodes of toxic shock syndrome within a short period of time. Both occasions were associated with menstruation. Mycoplasma hominis was isolated in the tracheal secretions once. Discussion: The etiology of the toxic shock syndrome has been extensively described. The toxic shock syndrome toxin-1 acts as a superantigen in toxic shock syndrome and interestingly a similar mechanism is discussed in juvenile rheumatoid arthritis. This case report demonstrates the possibility of a close relationship between toxic shock syndrome and juvenile rheumatoid arthritis and raises the suspicion of a similar immunopathogenetic process.
    Notes: Zusammenfassung Eine Patientin mit juveniler chronischer Arthritis erlitt im Alter von 16 Jahren in kurzem Abstand im Zusammenhang mit der Menstruation 2mal ein toxisches Schocksyndrom. Bei der 2. Episode konnte Mycoplasma hominis im Trachealsekret nachgewiesen werden. Diskussion: Beim toxischen Schocksyndrom ist die Ätiologie, das Toxic-shock-Syndrom-Toxin-1, welches als Superantigen die Krankheit auslöst, bekannt. Bei der juvenilen chronischen Arthritis wird ein ähnlicher Mechanismus diskutiert. Unser Fallbeispiel läßt vermuten, daß beiden Krankheiten ähnliche immunpathogenetische Prinzipien zugrundeliegen,.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001120050255
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  • 2
    Electronic Resource
    Electronic Resource
    Long-Term Responses to Treatment Including Ritonavir or Nelfinavir in HIV-1-Infected Children (2000)
    Springer
    Infection 28 (2000), S. 287-296 
    Details
    ISSN: 1439-0973
    Keywords: Key Words Ritonavir ; Nelfinavir ; Children ; Antiretroviral agents ; HIV-1
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Background: Knowledge concerning the long-term antiretriviral and immunological efficacy of protease inhibitors in children is limited. Patients and Methods: An open-label, prospective, multicenter clinical trial was conducted over a period of 72 weeks in Switzerland. 60 HIV-1 infected children (aged 0.3–16.9 years) naive to protease inhibitors were enrolled. Ritonavir or nelfinavir and at least one new nucleoside reverse transcriptase inhibitor were introduced into the durrent treatment regimen. HIV-1 RNA levels and CD4 cell counts were monitored after introducing the protease inhibitor, and the tolerability and safety of the drugs were assessed. Results: Dictated by chronological availability, 37 children received ritonavir and 23 nelfinavir. At baseline, children given ritonavir had higher mean plasma HIV-1 RNA levels (5.03 vs 4.63 log10 copies/ml; p = 0.001) and lower mean CD4 cell counts (277 vs 555 cells/μl; p = 0.009) than children given nelfinavir. Antiretroviral treatment (ART) naive children showed higher mean plasma HIV-1 RNA levels than non-naive (5.18 vs 4.64 log10 copies/ml; p = 0.02). The decline in plasma HIV-1 RNA levels 72 weeks after treatment with ritonavir and nelfinavir was −2.17 and −1.30 log10 copies/ml, respectively (p = 0.006) and in ART-naive vs non-naive patietns −2.70 vs − 1.39 log10 copies/ml (p ≤ 0.01). 69% of ART-naive patients and 32% of non-naive patients achieved sustained plasma HIV-1 RNA levels 〈 400 copies/ml. Increases in CD4 cells were higher in ART naive compared to non-naive patients (p 〈 0.04). Conclusion: The antiretroviral and immunologic benefits of protease inhibitors are more profound in ART-naive than in non-naive children.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s150100070021
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    Paper (German National Licenses)
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