ISSN:
1432-2072
Keywords:
Conditional Avoidance Response
;
Asymmetric Behavior-Controlling State
;
Catecholamines
;
Serotonin
;
Reserpine
;
Syrosingopine
;
Amphetamine
;
3,4-dihydroxyphenylalanine
;
5-Hydroxytryptophan
;
Hydroxyamphetamine
;
Parachlorophenylalanine
;
Methyl-p-tyrosine
;
Chlorpromazine
;
Cyproheptadine
;
State-Dependent Learning
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Conditional avoidance responses acquired under amphetamine were recalled without deficit only when tested under amphetamine (“amphetaminestate” dependent learning). Hydroxyamphetamine was devoid of this property. Dihydroxyphenylalanine (DOPA) but not 5-hydroxytryptophan (5-HTP) substituted for amphetamine while reserpine but not syrosingopine eliminated the “amphetamine-state”. DOPA and 5-HTP, only when given together, restored the “amphetamine-state” in reserpinized animals. DOPA alleviated the deficit in retention which was caused by methyl-p-tyrosine. 5-HTP alleviated the similar deficit caused by p-chlorophenylalanine. Chlorpromazine or cyproheptadine antagonized the “amphetamine-state”. It is suggested that amphetamine, but not hydroxyamphetamine is capable of producing an asymmetric behavior-controlling state. The “amphetamine-state” is related to the stimulation of central and not peripheral amine-receptors and depends on newly synthesized catecholamines which stimulate central catecholamine receptors through serotonin modulation in this case.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00422501
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