ISSN:
1432-2307
Keywords:
Insulin-like growth factor II
;
Hypoglycaemia
;
Gastric cancer
;
Non-islet cell tumour hypoglycaemia
;
Insulin receptor
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract A gastric cancer with liver metastases was associated with low morning levels of plasma glucose (24 mg/dl), insulin (〈2.5 μU/ml) and growth hormone (0.23 ng/ml). Primary and metastatic tumour tissue stained positively with anti-insulin-like growth factor II(IGF-II) monoclonal antibody. Western immunoblot analysis revealed a high molecular weight IGF-II in the serum: 15 kDa (normal: 7.5 kDa). Postmortem reverse transcription polymerase chain reaction on mRNA from both sites revealed 471 base pairs size cDNA encoding prepro-IGF-II. These results suggest that the gastric carcinoma encoded, expressed, and secreted IGF-II, probably causing the extrapancreatic tumour hypoglycaemia.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00190569
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