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  • Cholinergic drugs  (1)
  • Electromyography  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Springer
    Research in experimental medicine 158 (1972), S. 280-287 
    ISSN: 1433-8580
    Schlagwort(e): Colon motility ; Smooth muscle electrical activity ; Cholinergic drugs ; Morphine ; Slow waves
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary 1. The effects of bethanechol and morphine on electrical and motor activity of the colon were studied by means of needle electrodes and extraluminal strain transducers in 6 unanesthetized cats. 2. Bethanechol and morphine stimulated circular contractions to a similar extent. The contractile pattern after bethanechol injection appeared to be more organized than that after morphine. Bethanechol often caused defecation, morphine induced vomiting. 3. Both drugs lowered slow-wave frequency and increased the occurrence of faster electrical potentials. But bethanechol predominantly activated spiking, whereas the opiate caused long sequences of oscillations besides enhancing spike activity. 4. It is concluded that electromyography of the colon in situ allows differentiation between the effects of the two drugs and indicates different mechanisms of action. The apparent differences observed during previous experimentsin vitro with regard to slow-wave frequency point to the influence of extracolonic factors on the colonic slow wave.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Springer
    Research in experimental medicine 169 (1976), S. 83-91 
    ISSN: 1433-8580
    Schlagwort(e): Large intestine ; Gastrointestinal motility ; Electromyography ; Circadian rhythm ; Cat
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Since circadian patterns of colonic motility are largely unknown the electrical activity of the colon musculature was recorded in 6 unanesthetized cats during day and night. All parts of the colon exhibited 6 patterns of electrical activity: spikes, oscillations, omnipresent regular slow waves, and three composite patterns, i.e. a minute-rhythmic activity, activity complexes of 1 to 18 minute duration and a nyctohemeral pattern. The circadian rhythm was different between the proximal and distal colon resulting in activity gradients. These were directed in an aborad direction from 7 to 9 a.m. and from 9 p.m. to midnight. Most of the defecations of the 6 cats occured in the late evening until 1 a.m. Spike activity of the distal colon predominated from 3 to 4 a.m. and from 11 a.m. to 5 p.m. It is concluded that a circadian rhythm exists in the motility of the cat colon. Differences in the activity between the proximal and the distal colon and resulting activity gradients may offer an explanation for the influences of the time of day on the timing of defecations.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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