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  • 1
    Electronic Resource
    Electronic Resource
    Upper esophageal sphincter function in patients with Zenker's diverticulum (1988)
    Springer
    Dysphagia 3 (1988), S. 90-92 
    Details
    ISSN: 1432-0460
    Keywords: Zenker's diverticulum ; Esophageal motility
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Upper esophageal sphincter function (UES) was studied in 8 patients with Zenker's diverticulum. Radiologic and endoscopic studies revealed pharyngoesophageal diverticula of varying size. No tumor or stenosis was found. Esophageal manometry showed no significant difference between patients and 8 matched controls with respect to UES resting pressure, delay of maximal UES relaxation, and maximal pharyngeal contraction. All patients exhibited a drop of the UES pressure to esophageal resting pressure during swallowing. These results indicate that disturbances of UES function in established Zenker's diverticulum are a myth.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02412426
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  • 2
    Electronic Resource
    Electronic Resource
    Exsudative enteropathie beim klippel-trenaunay-syndrom (1988)
    Springer
    Journal of molecular medicine 66 (1988), S. 502-507 
    Details
    ISSN: 1432-1440
    Keywords: Klippel-Trénaunay-Syndrome ; Lymph flow obstruction ; Protein-loosing enteropathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The triad of the Klippel-Trénaunay Syndrome consists of varicose veins, “port-wine” haemangioma of the skin and bone and soft-tissue hypertrophy with a different extension. Often an obstruction of lymphatic vessels and lymphoedema accompany the syndrome. We observed for the first time a patient with an impressive Klippel-Trénaunay-Syndrome in combination with a symptomatic exsudative enteropathy. In spite of a regular intravenous protein substitution for many years, this patient had develloped a monstrous elephantiasis of the lower extremities. A lymphography demonstrated a blockade of the lymph flow at the height of the middle paraaortic lymph nodes. The cysterna chyli and the Ductus thoracicus were not visualised. The measurement of51Cr-labelled albumin excretion in the stool for two days after the intravenous injection of 3.07 MBq51Cr showed an excretion of 17.9% of the total dose, which means an elevated gastrointestinal protein-loss. However, intestinal lymphangiectasia was not seen on histologic examination of bioptic material of duodenal and jejunal mucosa. These results show that the Klippel-Trénaunay Syndrome may be accompanied by a protein-loosing enteropathy due to obstruction of the gastrointestinal lymph flow. As the intestinal lymphangiectasia may occur locally, it is not always demonstrable directly on pathologic examination of biopsies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01876173
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  • 3
    Electronic Resource
    Electronic Resource
    Serumlipoproteine bei akuter Virushepatitis (1974)
    Springer
    Journal of molecular medicine 52 (1974), S. 617-623 
    Details
    ISSN: 1432-1440
    Keywords: Lipoproteins ; hepatitis ; gel diffusion test ; immunoelectrophoresis ; ultracentrifugation ; Lipoproteine ; Hepatitis ; Geldiffusionstest ; Immunelektrophorese ; Ultrazentrifuge
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 20 Patienten mit akuter Virushepatitis wurden die Serumlipoproteine sowohl im Nativserum als auch nach präparativer Ultrazentrifugation mittels lipidelektrophoretischer und immunologischer Methoden näher untersucht; zusätzlich wurden die HDL-Fraktionen durch Disc-Elektrophorese bestimmt. Bei akuter Virushepatitis finden sich ausgeprägte quantitative Veränderungen der Lipoproteinfraktionen: Dieα-Lipoproteine sind stark herabgesetzt und fallen bis zur 3. Woche weiter ab. Dieβ-Lipoproteine sind dagegen signifikant erhöht und steigen bis zur 3. Woche weiter an. Eine mäßige konstante Verminderung der prä-β-Lipoproteine findet sich während des gesamten Krankheitsverlaufes. Ab der 6. Woche nach Krankheitsbeginn normalisieren sich die Werte. Zusätzlich werden bei einem Teil der Patienten mit Virushepatitis folgende qualitative Veränderungen beobachtet: Auf Acetatfolien trennen sich dieβ- und prä-β-Lipoproteinbande, dieα-Lipoproteinbande und die im Albuminbereich befindliche Bande ungenügend auf. Nach Ultrazentrifugation lassen sich diese jedoch mit immunologischen Methoden einheitlich den bereits bekannten normalen zuordnen, so daß Änderungen der Wanderungsgeschwindigkeit im elektrischen Feld angenommen werden müssen. Die Untersuchungen zeigen also, daß im Verlauf einer Virushepatitis reversible und typische quantitative und qualitative Veränderungen der Serumlipoproteine auftreten.
    Notes: Summary Lipoproteins of 20 patients with acute viral hepatitis were studied in native serum and in serum after preparative ultracentrifugation by means of lipid electrophoretic and immunological methods; in addition, HDL fractions were analysed by disc-electrophoresis. Pronounced quantitative alterations of the lipoprotein fractions occur in acute viral hepatitis: Theα-lipoproteins are markedly reduced and decrease further during the first 3 weeks. On the other hand, theβ-lipoproteins are significantly elevated and increase further during the first 3 weeks. The prae-β-lipoproteins are moderately, but regularly reduced during the whole course of the disease. 6 weeks after the onset of the disease the lipoproteins begin to normalize. In addition, in some patients the following qualitative alterations are observed during viral hepatitis:β- and prae-β-lipoproteins,α-lipoproteins and lipoproteins within the albumin fraction are incompletely separated on acetate foils. However, ultracentrifugal separation indicates that these lipoproteins belong to the well known fractions, thus indicating an altered speed of migration in the electrical field. These observations demonstrate that reversible and typical quantitative and qualitative alterations of the serum lipoproteins take place in the course of viral hepatitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468796
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  • 4
    Electronic Resource
    Electronic Resource
    Intrahepatische Cholestase und aplastische Anämie nach Prajmalin-Einnahme (1988)
    Springer
    Journal of molecular medicine 66 (1988), S. 264-270 
    Details
    ISSN: 1432-1440
    Keywords: Intrahepatic cholestasis ; Aplastic anemia ; N-propylajmaline
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Intrahepatic cholestasis and aplastic anemia after N-propylajmaline. A 43 year old female patient taking oral contraceptives for more than five years received the antiarrhythmic drug N-propylajmaline for treatment of ventricular arrhythmia. After twelve days (totale dosage 510 mg N-propyl-ajmaline) acute severe intrahepatic cholestasis and aplastic anemia developed. The erythropoeisis improved after three weeks of treatment with corticosteroids. However, despite treatment with phenobarbital the jaundice receded very slowly. Even after nine years of follow-up cholestatic enzymes are still significantly elevated although serum bilirubin levels are in the normal range. This case report demonstrates that antiarrhythmic drugs may induce nearly irreversible intrahepatic cholestasis and severe hematological disturbances.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01748169
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  • 5
    Electronic Resource
    Electronic Resource
    Long-term manometry of tubular esophagus in progressive systemic sclerosis (1994)
    Springer
    Journal of molecular medicine 72 (1994), S. 343-349 
    Details
    ISSN: 1432-1440
    Keywords: Long-term manometry ; Progressive systemic sclerosis ; Esophageal involvement
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Long-term manometry of the tubular esophagus was performed in 20 consecutive patients (18 females, 2 males; median age 56.5 years) with progressive systemic sclerosis (PSS) and a control group of 20 healthy subjects (18 females, 2 males; median age 56.5 years). The measurements were performed via a data logger of 1 MByte memory capacity with the help of two pressure sensors placed 8 and 18 cm above the lower esophageal sphincter. Esophageal contractions were analyzed with respect to pressure amplitudes in the esophagus distal and proximal, quotient of pressure amplitudes distal/proximal, number of contraction waves in a 24-h period, and kind of spreading (propulsive, simultaneous). In the PSS group there was a significant decrease in pressure amplitudes in the distal sensor (median 31.5 versus 39.5 mbar in controls, P 〈 0.02), in the quotient of pressure amplitudes distal/proximal (median 0.885 versus 1.25 in controls, P 〈 0.001), in the number of waves in 24 h (median 939.5 versus 1656 in controls, P 〈 0.01), and in the occurrence of propulsive waves (median 34% versus 57% in controls, P 〈 0.01). Fifteen patients (75%) had hypomotility disorders as compared to the control group, in which the lower limit of normal values was defined by the 5th percentile of descriptive analysis. These first data of long-term manometry in patients with PSS indicate that long-term manometry may be an effective method for identifying esophageal involvement in PSS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00252825
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  • 6
    Electronic Resource
    Electronic Resource
    The effect of trospium chloride on oesophageal motility (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Alimentary pharmacology & therapeutics 7 (1993), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Trospium chloride is a muscarinergic antagonist acting on oesophageal smooth muscle and on ganglionic and/or myenteric neurons. The effect of this drug on oesophageal motility was tested in 16 healthy male subjects in a double-blind randomized cross-over examination of trospium chloride or placebo following phentolamine or placebo application. Each subject underwent two separate investigations at least one week apart. Trospium chloride was effective in the oesophagus to reduce contractile activity (amplitude and duration of peristalsis) in all parts of the oesophageal body, and this effect was not blocked by phentolamine. Its potent action and its minor side-effects appear to be promising for clinical use in patients with motility disorders such as the hypercontractile oesophagus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.1993.tb00072.x
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  • 7
    Electronic Resource
    Electronic Resource
    The effect of cisapride on defaecation in normal human subjects—lack of effect on faecal excretion of water, fat, and bile acids (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Alimentary pharmacology & therapeutics 3 (1989), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In order to elucidate whether or not the increased stool frequency that occurs during cisapride treatment is a result of malabsorption of water, fat, and bile acids, 12 healthy volunteers were dosed with either tablets of placebo q.d.s. or tablets of 10 mg cisapride q.d.s. during two periods of 5 days in a double-blind, crossover study.Stool frequency, stool consistency, and side-effects were recorded each day. Total faecal mass, faecal water content, and faecal excretion of fat and bile acids were determined during the last 72 h of each study period.Mean daily stool frequency was 18.8% higher during cisapride [1.68 ± 0.12 (S.E.M.)] administration than during placebo (1.42 ± 0.12); P= 0.038. The stool consistency score increased by 11.8% towards softer stools during cisapride dosing (N.S.). There were no significant differences in total faecal mass (placebo 399.4 g/72 h; cisapride; 414.5 g/72 h), faecal water content (placebo; 75.6%: cisapride 76.2%), or faecal excretion of fat (placebo; 12.7 g/72 h: cisapride; 11.6 g/72 h) and total bile acids (placebo; 2212 μmol/72 h: cisapride; 2261 μmol/72 h). The side-effects reported during placebo were constipation (n = 3), and during cisapride meteorism (n = 4) and increased appetite (n = 2).The increased stool frequency during cisapride treatment is not caused by malabsorption of water, fat, or bile acids, but seems to be the consequence of a direct motor effect.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.1989.tb00246.x
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  • 8
    Electronic Resource
    Electronic Resource
    Dose finding study of mosapride in functional dyspepsia: a placebo-controlled, randomized study (2002)
    Oxford UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 16 (2002), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Prokinetic agents have shown variable efficacy in the treatment of functional dyspepsia. Mosapride is a new prokinetic 5-hydroxytryptamine-4 agonistic agent.〈section xml:id="abs1-2"〉〈title type="main"〉Aim:To evaluate the efficacy of three dosage regimens of mosapride compared with placebo in the treatment of functional dyspepsia.〈section xml:id="abs1-3"〉〈title type="main"〉Methods:Patients were randomly allocated to treatment with placebo or mosapride (5 mg b.d., 10 mg b.d. or 7.5 mg t.d.s.) in a double-blind, prospective, multicentre, multinational study. The change in symptom severity score from an untreated baseline week to the sixth week of treatment was used to compare treatment efficacy.〈section xml:id="abs1-4"〉〈title type="main"〉Results:There were 141, 140, 143 and 142 patients valid for evaluation in the intention-to-treat population in the placebo, mosapride 5 mg b.d., mosapride 10 mg b.d. and mosapride 7.5 mg t.d.s. groups, respectively. The mean changes in the overall dyspeptic symptom score were – 0.90, – 0.94, – 0.88 and – 0.89, respectively, and the proportions of patients feeling better at the end of the treatment period were 60%, 59%, 59% and 61%, respectively. No statistically significant difference was seen.〈section xml:id="abs1-5"〉〈title type="main"〉Conclusions:Treatment of functional dyspepsia with mosapride was not superior to placebo. The result raises the question of whether treatment with prokinetic agents is appropriate for functional dyspepsia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.2002.01236.x
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  • 9
    Electronic Resource
    Electronic Resource
    Der Einfluß des Alters auf die Analsphinkterfunktion bei der Frau (1996)
    Springer
    Der Gynäkologe 29 (1996), S. 757-760 
    Details
    ISSN: 1433-0393
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Die Analsphinkterfunktion der Frau nimmt mit zunehmendem Alter ab; sowohl der innere als auch der äußere Analsphinkter sind betroffen. Da die Ausgangsdruckwerte bei Frauen niedriger sind als bei Männern, Geburtsschäden am N. pudendus hinzukommen können und deren Folgen sich oft erst nach der Menopause manifestieren, betrifft die anale Inkontinenz besonders häufig alte Frauen. Als aussichtsreiche Therapie steht das Analbiofeedbacktraining zur Verfügung.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001290050076
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  • 10
    Electronic Resource
    Electronic Resource
    9. Hiatusbruch, Sphincterinsuffizienz, Refluxoesophagitis: Endoskopie, Manometrie, konservative Therapie (1974)
    Springer
    Langenbeck's archives of surgery 337 (1974), S. 103-108 
    Details
    ISSN: 1435-2451
    Keywords: Reflux Esophagitis ; Endoscopy ; pH Measurement ; Esophageal Manometry ; Refluxoesophagitis ; Endoskopie ; pH-Messung ; Oesophagusmanometrie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Diagnostisch notwendig bei der Refluxkrankheit des Oesophagus sind eingehende Anamneseerhebung, röntgenologische und endoskopisch-histologische Untersuchungen. Wünschenswert sind intraoesophageale pH-Messung und Manometrc. Entbehrlich sind Magensekretionsanalyse, PD-Messung und Säureperfusionstest. Bei der ulcerierend-stenosierenden Entzündung sollte operiert, bei den anderen Formen zunächst 3—6 Monate intensiv konservativ behandelt werden: Antacida, proteinreiche, fettarme Kost, Nicotinund Alkoholabstinenz, Bettkopfende anheben, Körpergewicht normalisieren.
    Notes: Summary A detailed history, radiology, endoscopy and histology are indispensable in the diagnosis of reflux disease of the esophagus. Measurement of esophageal pH and manometry are useful, whereas gastric secretory analysis, measurement of PD and the acid perfusion test can be omitted. Severe esophagitis with ulcers and stenosis requires surgery, while in the case of other reflux problems conservative treatment can first be applied for 3 to 6 months: Antacids, high-protein and low-fat diet, no nicotine, no alcohol, elevation of the bed head, normalization of body weight.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01278641
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