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  • 1
    Electronic Resource
    Electronic Resource
    Screening for thyroid disorders in a working population (1993)
    Springer
    Journal of molecular medicine 71 (1993), S. 126-131 
    Details
    ISSN: 1432-1440
    Keywords: Subclinical thyroid disorders ; Sonography ; Epidemiology ; Goiter
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Subclinical thyroid disorders have received increasing attention in recent years due to refined laboratory methods and a stronger emphasis on the role of preventive medicine. We performed a screening for thyroid-stimulating hormone (TSH) on 6884 persons in a working population. In cases in which TSH was not within the normal range we also measured the levels of triiodothyronine (T3), thyroxine (T4), and thyroxine-binding globulin (TBG). All persons who did not present with exclusion criteria or other nonthyroidal illnesses (n = 59) and the controls (n = 39) were submitted to thyrotropin-releasing hormone (TRH)-testing. Additionally, sonography of the thyroid was performed on 120 persons (59 subjects with abnormal hormone levels and 61 controls) to determine thyroid size and rule out morphological abnormalities. Based on the TRH test and T3, T4, and TBG measurements we found a prevalence of 0.03% (2/6884) for overt hyperthyroidism, 0.33% (23/6884) for subclinical hyperthyroidism, 0.09% (6/6884) for subclinical hypothyroidism, and 0.015% (1/6884) for overt hypothyroidism in the healthy population. In subjects with overt or subclinical hyperthyroidism the prevalence of goiters (thyroid volume 〉 18 ml in women, 〉 25 ml in men) was 28%. Of this group 48% had structural abnormalities. All persons with goiters and/or structural abnormalities were over 35 years of age. Among the euthyroid, 20% had thyroid enlargement, and the same proportion presented with structural abnormalities. There were no differences between the two age groups. In the group with overt/subclinical hypothyroidism 47% presented with structural abnormalities of the thyroid; however, none presented with thyroid enlargement. Thyroid nodules were found only in older persons (〉 〉 35 years) with euthyroidism or hypothyroidism. These data confirm the relatively high prevalence of functional and morphological abnormalities of the thyroid. An early substitution with iodine is warranted to prevent functional and morphological disorders of the thyroid in older age. People with subclinical hyperthyroid disorders must avoid exposure to iodine, which can cause an exacerbation of the disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00179993
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  • 2
    Electronic Resource
    Electronic Resource
    Zur problematik der begutachtung von bronchialcarcinomen nach exposition gegenüber chromverbindunge (1979)
    Springer
    International archives of occupational and environmental health 43 (1979), S. 107-121 
    Details
    ISSN: 1432-1246
    Keywords: Bronchial carcinoma ; Chromates ; Occupational disease ; Criteria for evaluation ; Bronchialcarcinom ; Chromate ; Berufskrankheit ; Beurteilungskriterien
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Situation bei potentiell cancerogenen Chromverbindungen in der Liste der maximalen Arbeitsplatzkonzentrationen (MAK-Werte) 1978 wird geschildert. Ein empirisch-kasuistischer Bericht über 27 Fälle von Lungenerkrankungen nach Exposition gegenüber verschiedenen Chromverbinduneen schließt sich an. Zur Auswertung gelangten dabei Unterlagen der Berufsgenossenschaft der Chemischen Industrie aus sieben Firmen mit Expositionszeiten zwischen 1899 und 1968. In tabellarischer Form werden Angaben fiber 14 Fälle von Bronchial-carcinom nach Exposition gegenüber Chrom-VI-Verbindungen, drei Fälle von Bronchialcarcinom nach Exposition gegenüber Chrom-III-Verbindungen, acht Fälle von Lungenerkrankungen ohne Carcinom und zwei weitere Fälle gemacht. Unter Bezug auf these Daten und die neuere Literatur erfolgt eine Diskussion anhand von Kriterien zur Anerkennung bösartiger Neubildungen als Berufskrankheit. Die Wahrscheinlichkeit bzw. Möglichkeit von Ursache und Wirkung wird diskutiert. Die Bedeutung von arbeitsmedizinischen Vorsorgeuntersuchungen am entsprechend exponierten Arbeitsplatz and besonders die Chrombestimmung im Urin als Nachweis einer Einwirkung wird hervorgehoben.
    Notes: Summary The present situation concerning potentially cancerogenous chromium compounds listed in the table of threshold limit values (TLV's) is described, followed by an empirical case report on 27 cases of diseases of the lung after exposition to various chromium compounds. A documentation of the ‘Berufsgenossenschaft der Chemischen Industrie’ (Association of the Chemical Industry) covering seven companies with exposition times between 1899 and 1968 was evaluated for this report. Information on 14 cases of bronchial carcinoma after exposition to chromium-VI compounds, on three cases of bronchial carcinoma after exposition to chromium-III compounds, eight cases of lung disease without carcinoma, and two additional cases is presented in the form of tables. A discussion concerning the criteria of confirmation of new malignancies as occupational diseases, based on the data presented and on recent literature, follows. The probability, and/or the possibility of cause and effect is discussed. The importance of preventive check-ups in the field of occupational medicine at the working locations, correspondingly exposed, and particularly the determination of chromium in the urine are emphasized.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00378149
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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