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  • 1
    Electronic Resource
    Electronic Resource
    Zur problematik der begutachtung von bronchialcarcinomen nach exposition gegenüber chromverbindunge (1979)
    Springer
    International archives of occupational and environmental health 43 (1979), S. 107-121 
    Details
    ISSN: 1432-1246
    Keywords: Bronchial carcinoma ; Chromates ; Occupational disease ; Criteria for evaluation ; Bronchialcarcinom ; Chromate ; Berufskrankheit ; Beurteilungskriterien
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Situation bei potentiell cancerogenen Chromverbindungen in der Liste der maximalen Arbeitsplatzkonzentrationen (MAK-Werte) 1978 wird geschildert. Ein empirisch-kasuistischer Bericht über 27 Fälle von Lungenerkrankungen nach Exposition gegenüber verschiedenen Chromverbinduneen schließt sich an. Zur Auswertung gelangten dabei Unterlagen der Berufsgenossenschaft der Chemischen Industrie aus sieben Firmen mit Expositionszeiten zwischen 1899 und 1968. In tabellarischer Form werden Angaben fiber 14 Fälle von Bronchial-carcinom nach Exposition gegenüber Chrom-VI-Verbindungen, drei Fälle von Bronchialcarcinom nach Exposition gegenüber Chrom-III-Verbindungen, acht Fälle von Lungenerkrankungen ohne Carcinom und zwei weitere Fälle gemacht. Unter Bezug auf these Daten und die neuere Literatur erfolgt eine Diskussion anhand von Kriterien zur Anerkennung bösartiger Neubildungen als Berufskrankheit. Die Wahrscheinlichkeit bzw. Möglichkeit von Ursache und Wirkung wird diskutiert. Die Bedeutung von arbeitsmedizinischen Vorsorgeuntersuchungen am entsprechend exponierten Arbeitsplatz and besonders die Chrombestimmung im Urin als Nachweis einer Einwirkung wird hervorgehoben.
    Notes: Summary The present situation concerning potentially cancerogenous chromium compounds listed in the table of threshold limit values (TLV's) is described, followed by an empirical case report on 27 cases of diseases of the lung after exposition to various chromium compounds. A documentation of the ‘Berufsgenossenschaft der Chemischen Industrie’ (Association of the Chemical Industry) covering seven companies with exposition times between 1899 and 1968 was evaluated for this report. Information on 14 cases of bronchial carcinoma after exposition to chromium-VI compounds, on three cases of bronchial carcinoma after exposition to chromium-III compounds, eight cases of lung disease without carcinoma, and two additional cases is presented in the form of tables. A discussion concerning the criteria of confirmation of new malignancies as occupational diseases, based on the data presented and on recent literature, follows. The probability, and/or the possibility of cause and effect is discussed. The importance of preventive check-ups in the field of occupational medicine at the working locations, correspondingly exposed, and particularly the determination of chromium in the urine are emphasized.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00378149
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Investigation of a cluster of ten cases of Hodgkin’s disease in an occupational setting (1996)
    Springer
    International archives of occupational and environmental health 68 (1996), S. 224-228 
    Details
    ISSN: 1432-1246
    Keywords: Key words Hodgkin’s disease ; Occupational exposure ; Nested case-control study.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The objective of this study was to identify occupational exposures that might be etiologically linked to an unusual cluster of ten cases of Hodgkin’s disease. The cases were identified within the active workforce of a large chemical manufacturing firm over a 23-year period by the medical director of the facilities. Based on comparison with regional cancer incidence rates, the standardized incidence ratio for Hodgkin’s disease was 497 (95% confidence interval: 238–915) for the period from the construction of the facilities in 1966 through early 1992. A nested case-control study was undertaken with 200 controls selected according to case-cohort sampling. Simultaneously, efforts were initiated to confirm and characterize each case more fully. Occupational exposures were identified and categorized using process, work history, medical record, and industrial hygiene data. Tissue slides were available for eight cases and a second review confirmed the diagnosis of Hodgkin’s disease. For one case, a final diagnosis of large-cell anaplastic lymphoma was determined after histology review. Among 214 different chemical agents studied, eight were identified to which three or more of the cases had been exposed prior to the date of their initial diagnosis. Exposure odds ratios were statistically elevated for five of these agents; dose-response evaluations for two of the agents, ethylene oxide and benzene, failed to provide additional support for a causal relationship. In conclusion, although several statistical associations were identified, no substance emerged as a likely candidate for explaining the observed Hodgkin’s disease cluster.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00381432
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Investigation of a cluster of ten cases of Hodgkin's disease in an occupational setting (1996)
    Springer
    International archives of occupational and environmental health 68 (1996), S. 224-228 
    Details
    ISSN: 1432-1246
    Keywords: Hodgkin's disease ; Occupational exposure ; Nested case-control study
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The objective of this study was to identify occupational exposures that might be etiologically linked to an unusual cluster of ten cases of Hodgkin's disease. The cases were identified within the active workforce of a large chemical manufacturing firm over a 23-year period by the medical director of the facilities. Based on comparison with regional cancer incidence rates, the standardized incidence ratio for Hodgkin's disease was 497 (95% confidence interval: 238–915) for the period from the construction of the facilities in 1966 through early 1992. A nested case-control study was undertaken with 200 controls selected according to case-cohort sampling. Simultaneously, efforts were initiated to confirm and characterize each case more fully. Occupational exposures were identified and categorized using process, work history, medical record, and industrial hygiene data. Tissue slides were available for eight cases and a second review confirmed the diagnosis of Hodgkin's disease. For one case, a final diagnosis of large-cell anaplastic lymphoma was determined after histology review. Among 214 different chemical agents studied, eight were identified to which three or more of the cases had been exposed prior to the date of their initial diagnosis. Exposure odds ratios were statistically elevated for five of these agents; dose-response evaluations for two of the agents, ethylene oxide and benzene, failed to provide additional support for a causal relationship. In conclusion, although several statistical associations were identified, no substance emerged as a likely candidate for explaining the observed Hodgkin's disease cluster.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00381432
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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