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  • Chromosome 1q41  (1)
  • Epidural haematoma  (1)
  • Germanium intoxication  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Experimental germanium myopathy (1991)
    Springer
    Acta neuropathologica 82 (1991), S. 55-59 
    Details
    ISSN: 1432-0533
    Keywords: Germanium intoxication ; Mitochondrial myopathy ; Ragged-red fiber ; Autophagic vacuole
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The long-term administration of germanium dioxide (GeO2) to rats produced Ge myopathy characterized by the formation of ragged-red fibers. The earliest pathological changes in experimental Ge myopathy were a decrease in cytochrome c oxidase activity and accumulation of high electron-dense materials in mitochondria. These findings suggest that a mitochondrial dysfunction may be most important in the genesis of experimental Ge myopathy, which could be a useful animal model for the investigation of and therapeutic trials for human mitochondrial myopathies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00310923
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Chronic expanding epidural haematoma (1995)
    Springer
    Acta neurochirurgica 132 (1995), S. 150-153 
    Details
    ISSN: 0942-0940
    Keywords: Epidural haematoma ; chronic epidural haematoma ; chronic expanding haematoma ; haematoma membrane
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An encapsulated fluid epidural haematoma in a 9-year-old boy was successfully evacuated by a simple burr hole procedure 5 months after a minor head injury. Clinicopathological findings suggested that chronic expansion of an initially unsuspected epidural haematoma occurred as a result of repeated haemorrhages from the haematoma membrane, resulting in an unusually long delayed appearance of clinical evidence. This case demonstrates that a chronic expanding process similar to that seen in chronic subdural haematoma needs to be considered as a possible complication of epidural haematoma and indicates an important role for the haematoma membrane in the chronic expansion of epidural haematoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01404865
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Genomic structure and chromosomal localization of the gene encoding TRAX, a Translin-associated factor X (2000)
    Springer
    Journal of human genetics 45 (2000), S. 305-308 
    Details
    ISSN: 1435-232X
    Keywords: Key wordsTRAX ; Chromosome 1q41 ; Nuclear targeting motif ; Translin ; Leucine zipper ; Heteropolymer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The TRAX gene encodes a Translin-associated 33-kDa protein partner, TRAX. The TRAX protein has extensive amino acid homology with Translin, and contains bipartite nuclear targeting sequences, suggesting a possible role in the selective nuclear transport of Translin lacking any nuclear targeting motifs. In the present study, genomic clones of the human TRAX gene were isolated to determine the complete genomic organization. The genomic structure of the human TRAX gene was similar to that of the human Translin gene, consisting of six exons and five introns, encompassing approximately 27 kb in genomic DNA. Northern blot analysis revealed a predominant transcript of approximately 2.7 kb, and its distribution in various tissues was like that of Translin. Chromosomal mapping by fluorescence in situ hybridization (FISH) analysis allowed localization of the TRAX gene to human chromosome 1q41.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100380070022
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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