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  • 1
    ISSN: 1432-2072
    Keywords: Electroconvulsive shock ; Growth hormone ; Clonidine ; Rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of repeated electroconvulsive shocks (ECS) on growth hormone (GH) secretion was studied in rats. Male Sprague-Dawley animals were given one ECS daily for 10 days under halothane anaesthesia. Control animals were anaesthetised only. GH secretion was studied 24 h after the last ECS or sham procedure. Background GH secretion was significantly greater in ECS-treated than in sham-treated animals (P〈0.001). The GH response to IV clonidine (0.01–0.1 mg/kg) did not differ between the two groups. The size of the GH response was not directly related to the basal GH secretion and could not be explained in terms of it.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Psychopharmacology 81 (1983), S. 78-80 
    ISSN: 1432-2072
    Keywords: Clonidine ; Alcohol withdrawal ; Man
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Clonidine hydrochloride 5 μg/kg and placebo were given orally to 11 patients experiencing well-developed alcohol withdrawal states. Active drug and placebo were given in a randomised, cross-over double blind fashion 2 h apart. Clonidine significantly suppressed heart rate (P=0.002), arterial blood pressure (P=0.006), and an accumulated score of withdrawal symptoms and signs (P=0.004). These data suggest that clonidine may be useful in the management of alcohol withdrawal states, and that the underlying pathophysiology of at least some of these manifestations may be sympathetic nervous system hyperactivity.
    Type of Medium: Electronic Resource
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