ISSN:
1432-2161
Keywords:
Magnetization transfer contrast
;
Cartilage
;
MTC-subtraction
;
Collagen
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Human articular cartilage from 16 cadaveric or amputated knees was studied using standard magnetic resonance imaging (MRI), on-resonance magnetization transfer contrast (MTC) and MTC-subtraction MRI. Results were compared with subsequent macroscopic and histopathological findings. MTC-subtraction and T2-weighted spin-echo images visualized cartilaginous surface defects with high sensitivity and specificity. MTC and T2-weighted spin-echo images revealed intra-cartilaginous signal loss without surface defects in 80% of the cases, corresponding to an increased collagen concentration. It is concluded that MTC is sensitive to early cartilage degeneration and MTC-subtraction can be helpful in detecting cartilage defects.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00223085
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