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  • 1
    ISSN: 0378-1119
    Keywords: F2 promoter ; Recombinant DNA provirus ; constitutive gene ; mammalian expression vectors ; splicing
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1438-2199
    Keywords: Amino acids ; Taurine ; Neurons ; NCAM ; Migration ; Transcription
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cultures of dissociated cerebellum from 5- to 6-day-old mice as well as of the N2A neuronal cell line were exposed to guanidino ethane sulfonate (GES, 2–5 mM) to reduce the cellular taurine content. Control cultures were kept in culture medium or medium containing 2–5 mM GES plus 2–5 mM taurine to restore the intracellular taurine content. Taurine depletion led to changes in the expression of certain splice variants of NCAM mRNA such as the AAG and the VASE containing forms, while no differences were seen in the expression of the three forms of NCAM protein. In the N2A cells taurine depletion led to a decreased migration rate of the cells. The results suggest that the reduced migration rate of neurons caused by taurine depletion may be correlated to changes in expression of certain adhesion molecules such as NCAM. Moreover, taurine appears to be involved in regulation of transcription processes.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 361 (1983), S. 213-220 
    ISSN: 1435-2451
    Keywords: Colon injuries ; Primary closure ; Exteriorisation ; Hartmanns' procedure ; Colonverletzung ; primäre Naht ; Vorverlagerung ; Hartmannsche Operation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Kombination von Beckenfraktur und Darmverletzung tritt in 0,05 des stationären Gesamtkrankengutes auf. Bei Beckenfrakturen sind die Hohlorgane Blase/Urethra in 14 %, Dünndarm in 6 %, Dickdarm in 5 % und Gefäße in 3 % mit verletzt. Männer stellen zu 75 % dieses Krankengut. Die Komplikations- und Letalitätsrate hängt ganz überwiegend vom Verteilungsmuster des Polytraumatisierten ab, aus ihnen stammen überwiegend die Darmverletzten. Verkehrsunfälle als Verletzungsursache überwiegen (ca. 70 %). In der Diagnostik der intraabdominellen Blutung hat die Lavage die größte Bedeutung. Dickdarmperforationen können gezielt durch trijodierte Kontrastmittel nachgewiesen werden. Innerhalb der 6 h-Grenze wird zur Versorgung der Dickdarmverletzung die primäre Naht bevorzugt, jenseits der 6 h-Grenze die Hartmannsche Operation bei intraperitonealer bzw. die Colostomie und Ausschaltung bei retroperitonealer Lage.
    Notes: Summary The combination of pelvic fractures and intestinal injuries occured in 0.05 % in all the patients of our hospital. Apart from pelvic fractures we found injuries of the urine bladder and urethra in 14 %, of the small intestine in 6 %, of the large intestine in 5 % and 3 % vascular lesions. 75 % of the injured patients are males. Morbidity and mortality rates depend on the combination of the injuries in polytraumatised patients among whom we found the patients with intestinal injuries. 70 % of the injured patients had blunt abdominal trauma after road accidents. The peritoneal lavage is most important for the diagnosis of intraabdominal bleeding. Colon perforations are effectively demonstrated by trijodized contrast mediums. Within a six hour time limit we prefer the primary closure. Later we perform Hartmanns' procedure in intraperitoneal lesions and colostomy in retroperitoneal lesions.
    Type of Medium: Electronic Resource
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