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  • Diptera  (3)
  • pheromone  (3)
  • Colour flow mapping  (2)
  • Cyclic AMP  (2)
  • 1
    Digitale Medien
    Digitale Medien
    Gene expression of the human prostaglandin E receptor EP4 subtype: differential regulation in monocytoid and lymphoid lineage cells by phorbol ester (1996)
    Springer
    Journal of molecular medicine 74 (1996), S. 333-336 
    Details
    ISSN: 1432-1440
    Schlagwort(e): Key words Prostaglandin E receptor ; EP4 subtype ; THP-1 ; Cyclic AMP ; Phorbol myristate acetate
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract  We isolated a cDNA clone encoding the human prostaglandin (PG) E receptor EP4 subtype and examined the gene expression in human blood cells. Northern blot analysis revealed that the EP4 gene is expressed at a high level in peripheral blood mononuclear cells, and at lower levels in cultured human blood cell lines, THP-1 and U937 (monocytoid cell lines), MOLT-4 and Jurkat (T-cell lines), and Raji (B-cell line). To examine regulation of the EP4 gene expression in the immune system, we studied the effects of phorbol 12-myristate 13-acetate (PMA) on these cell lines. Gene expression was upregulated in THP-1, U937, and Raji cells by PMA, and was downregulated in MOLT-4 and Jurkat cells. In THP-1 cells the effects of PMA were further analyzed, and the upregulation of the EP4 gene was shown to be followed by an increase in PGE2 binding sites and in PGE2-induced cAMP accumulation. In the striking contrast, other PGE receptor subtypes (EP1, EP2 and EP3) and other prostanoid receptors (IP and DP) were shown not to be upregulated by PMA. Therefore, this is the first demonstration of a highly specific upregulation of the EP4 subtype in THP-1 cells treated with PMA, suggesting the importance of the EP4 subtype in the immune system. In the present study we also clarified that EP4 gene expression is regulated differently among human monocytoid and lymphoid lineage cells, thus leading to the better understanding of the regulatory mechanisms for the human EP4 gene expression in the immune system.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s001090050034
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  • 2
    Digitale Medien
    Digitale Medien
    Echocardiographic evaluation of the development of aortic valve prolapse in supracristal ventricular septal defect (1995)
    Springer
    European journal of pediatrics 154 (1995), S. 176-181 
    Details
    ISSN: 1432-1076
    Schlagwort(e): Key words Supracristal ventricular septal defect ; Aortic valve prolapse ; Aortic regurgitation ; Colour flow mapping
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The development and timing of aortic valve prolapse (AoVP) and aortic regurgitation (AR) was studied by two-dimensional echocardiography in 99 consecutive patients with supracristal ventricular septal defect (VSD). Thirty patients (30%) had aortic valve prolapse (VSD + AoVP group), and 31 patients (31%) had AoVP with AR (VSD + AoVP + AR group). In the VSD + AoVP group, AoVP was detected first by echocardiography at the age of 6.8 ± 4.2 years (mean ± SD). In the VSD + AoVP + AR group, the interval from detection of AoVP to the appearance of AR was 3.4 ± 2.0 years. The configuration of the prolapsed aortic valve was echocardiographically classified into two types: tear-drop type (small) prolapse and box type (large) prolapse. The frequency of tear-drop type prolapse was not significantly different between VSD + AoVP and VSD + AoVP + AR groups (43% versus 32%, respectively), indicating that even minor AoVP can result in AR. Four infants (4%) had AoVP at the ages of 1, 5, 7, and 11 months, respectively. All infants had tear-drop type prolapse. Two infants developed AR by colour flow mapping at the ages of 3 and 11 months, and the interval from prolapse to AR was only 2 and 4 months, respectively. Conclusion Aortic valce involement can develop under the age of 1 year in supracristal VSD. Regular evaluation by two-dimensional echocardiography with colour flow mapping is important in the follow-up of children with supracristal VSD.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01954266
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  • 3
    Digitale Medien
    Digitale Medien
    Echocardiographic evaluation of the development of aortic valve prolapse in supracristal ventricular septal defect (1995)
    Springer
    European journal of pediatrics 154 (1995), S. 176-181 
    Details
    ISSN: 1432-1076
    Schlagwort(e): Supracristal ventricular septal defect ; Aortic valve prolapse Aortic regurgitation ; Colour flow mapping
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The development and timing of aortic weve prolapse (AoVP) and aortic regugitation (AR) was studied by two limensional echocardiography in 99 consecutive patients with supracristal ventricular septal defect (VSD). Thirty patients (30%) had aortic valve prolapse (VSD+AoVP group), and 31 patients (31%) had AoVP with AR (VSD+AoVP+AR group). In the VSD+AoVP group, AoVP was detected first by echocardiography at the age of 6.8±4.2 years (mea±SD). In the VSD+AoVP+AR group, the interval from detection of AoVP to the appearance of Al was 3.4±2.0 years. The configuration of the prolapsed aortic valve was echocardiographically classified into two types: teardrop type (small) prolapse and box type (large) prolapse. The frequency of tear-drop tyrolapse was not significantly different between VSD+AoVP and VSD+AoVP-AR groups (43% versus 32%, respectively), indicating that even minor AoVP can result, AR. Four infants (4%) had AoVP at the ages of 1, 5, 7, and 11 months, respectively. All infants had tear-drop type prolapse. Two infants developed AR by colour flow mapping at the ages of 3 and 11 months, and the interval from prolapse to AR was only 2 and 4 months, respectively. Conclusion Aortic valce, involement can develop under the age of 1 year in supracristal VSD. Regular evaluation by two-dimensional echocardiography with colour flow mapping is important in the followup of children with supracristal VSD.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01954266
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  • 4
    Digitale Medien
    Digitale Medien
    Gene expression of the human prostaglandin E receptor EP4 subtype: differential regulation in monocytoid and lymphoid lineage cells by phorbol ester (1996)
    Springer
    Journal of molecular medicine 74 (1996), S. 333-336 
    Details
    ISSN: 1432-1440
    Schlagwort(e): Prostaglandin E receptor ; EP4 subtype ; THP-1 ; Cyclic AMP ; Phorbol myristate acetate
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract We isolated a cDNA clone encoding the human prostaglandin (PG) E receptor EP4 subtype and examined the gene expression in human blood cells. Northern blot analysis revealed that the EP4 gene is expressed at a high level in peripheral blood mononuclear cells, and at lower levels in cultured human blood cell lines, THP-1 and U937 (monocytoid cell lines), MOLT-4 and Jurkat (T-cell lines), and Raji (B-cell line). To examine regulation of the EP4 gene expression in the immune system, we studied the effects of phorbol 12-myristate 13-acetate (PMA) on these cell lines. Gene expression was upregulated in THP-1, U937, and Raji cells by PMA, and was downregulated in MOLT-4 and Jurkat cells. In THP-1 cells the effects of PMA were further analyzed, and the upregulation of the EP4 gene was shown to be followed by an increase in PGE2 binding sites and in PGE2-induced cAMP accumulation. In the striking contrast, other PGE receptor subtypes (EP1, EP2 and EP3) and other prostanoid receptors (IP and DP) were shown not to be upregulated by PMA. Therefore, this is the first demonstration of a highly specific upregulation of the EP4 subtype in THP-1 cells treated with PMA, suggesting the importance of the EP4 subtype in the immune system. In the present study we also clarified that EP4 gene expression is regulated differently among human monocytoid and lymphoid lineage cells, thus leading to the better understanding of the regulatory mechanisms for the human EP4 gene expression in the immune system.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00207510
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  • 5
    Digitale Medien
    Digitale Medien
    Absolute configuration of mosquito oviposition attractant pheromone, 6-acetoxy-5-hexadecanolide (1985)
    Springer
    Journal of chemical ecology 11 (1985), S. 643-648 
    Details
    ISSN: 1573-1561
    Schlagwort(e): Mosquito ; Culex pipiens fatigans ; Diptera ; Culicidae ; oviposition ; attractant ; pheromone ; chiral chromatography ; acetoxyhexadecanolide
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie
    Notizen: Abstract 6-Acetoxy-5-hexadecanolide (Ia) in the oviposition attractant pheromone released from egg apical droplets of the mosquitoCulex pipiens fatigans Wied. is shown to be the (−)-(5R,6S)- enantiomer. Identification was by chromatography of the 6-trifluoroacetoxy derivatives of the natural pheromone and of the synthetic (−)-(5R,6S)- (Ib) and (+)-(5S,6R)- (IIb) enantiomers on a capillary column having a chiral stationary phase comprising a derivative of (1S,3S)-chrysanthemic acid. The synthetic (−)-(5R,6S)- enantiomer (Ia) attracted oviposition of four fold more mosquito egg rafts than the control (P 〈 0.01) whereas for the (5S,6R)- enantiomer (IIa) there was no statistically significant oviposition attraction.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00988573
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  • 6
    Digitale Medien
    Digitale Medien
    Sex-specific activity of (R)-(−)- and (S)- (+)-1,7-dioxaspiro[5.5]undecane, the major pheromone ofDacus oleae (1986)
    Springer
    Journal of chemical ecology 12 (1986), S. 1559-1568 
    Details
    ISSN: 1573-1561
    Schlagwort(e): Dacus oleae ; olive fruit fly ; Diptera ; Tephritidae ; pheromones ; enantiomers ; sex attractants ; sex-specific enantiomers
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie
    Notizen: Abstract 1,7-Dioxaspiro[5.5]undecane (olean), the major component of the female sex attractant pheromone blend of the olive fruit flyDacus oleae (Gmelin) was shown to be released as a racemate. The response of males and females to pure (R)-(−) and (S)-(+)-enantiomers was tested under laboratory and field conditions. Males in laboratory and field tests responded only to (R)-(−)-olean, which functions as a sex attractant. Females responded only to (S)-(+)-olean in laboratory tests but not in the field. There are indications that the latter enantiomer fuctions as a short-range arrestant throughout the day and as an aphrodisiac in the process of mating.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01012372
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  • 7
    Digitale Medien
    Digitale Medien
    Sex Pheromone of Glossina tachinoides: Isolation, Identification, and Synthesis (1998)
    Springer
    Journal of chemical ecology 24 (1998), S. 1563-1575 
    Details
    ISSN: 1573-1561
    Schlagwort(e): Tsetse fly ; sex stimulant ; pheromone ; hydrocarbon ; methylalkanes ; gas chromatography ; Diptera ; biting fly
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie
    Notizen: Abstract Study of lipids from male and female laboratory-reared flies led to the demonstration of a potent contact sex stimulant in extracts and cuticular hydrocarbons of the female tsetse fly Glossina tachinoides (Westwood) against conspecific males. Thin-layer and column chromatography indicated that extracts contained hydrocarbons and saponifiable lipids. Biological activity was found in the alkanes from females, including prominent branched-chain alkanes that were detected by gas chromatography (GC). The alkanes were separated and collected by preparative gas chromatography (GC), and only the 37-carbon region showed biological activity. GC–mass spectrometry showed the major peak contained a mixture of isomeric 11,23-, 13,25- plus a minor amount of 11,21-dimethylheptatriacontane. Two racemic isomers were synthesized, and bioassays showed that the greatest activity was possessed by the 11,23- isomer with somewhat less activity in 13,25-dimethyl heptatria-contane. Dose–response data showed ED50 at 5 μg per decoy with solvent-washed males, nonspecific females, or corks as decoys. These alkanes released sexual activity in males that comprised most of the behaviors released by a female fly of the same species.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1020967918594
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  • 8
    Digitale Medien
    Digitale Medien
    Southern pine beetle: Olfactory receptor and behavior discrimination of enantiomers of the attractant pheromone frontalin (1982)
    Springer
    Journal of chemical ecology 8 (1982), S. 873-881 
    Details
    ISSN: 1573-1561
    Schlagwort(e): Enantiomers ; bark beetle ; pheromone ; Dendroctonus frontalis ; Coleoptera ; Scolytidae ; southern pine beetle ; electrophysiology ; olfaction
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie
    Notizen: Abstract In laboratory and field bioassays, the response ofDendroctonus frontalis was significantly greater to the mixture of (1S, 5R)-(−)-frontalin andalpha-pinene than to (1R,5S)-(+)-frontalin andalpfa-pinene. Electro-physiological studies revealed that antennal olfactory receptor cells were significantly more responsive to (1S, 5R)-(−)-frontalin than to (1R, 5S)-(+)-frontalin. Both enantiomers stimulated the same olfactory cells which suggests that each cell possesses at least two types of enantiomer-specific acceptors.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00994788
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