ISSN:
1569-8041
Keywords:
Epstein–Barr virus
;
gastric lymphoma
;
Helicobacter pylori
;
mucosa-associated lymphoid tissue
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Background: Helicobacter pylori (H. pylori) infection has been postulated to be a pathogenetic factor in gastric lymphoma. However, the etiological factors for gastric lymphoma could vary in different populations. Materials and methods: We looked for histological evidence of H. pylori infection in 53 gastrectomy specimens from Hong Kong Chinese patients with primary gastric B-lymphoma. We also screened for Epstein–Barr virus(EBV) in these cases using in situ hybridization with oligonucleotide probes for EBV-encoded small RNA1 and 2. Results: H. pylori was found in 29/53 (55%), including 8/13(62%) cases of low-grade lymphoma of mucosa-associated lymphoid tissue (MALT) type. These infection rates in gastric lymphoma are lower than those reported in Western populations (80%–100%) and comparable to that found in healthy Chinese blood donors (55%) or in non-ulcer dyspeptic patients (52%–57%). EBV was found in tumor cells only in one case of high-grade gastric lymphoma with low-grade MALT component which was H. pylori-negative, and in occasional nontumor lymphoid cells in 7 other cases. Conclusions: These results suggest that (1) the role of H. pylori in pathogenesis of gastric lymphoma may vary in different populations;(2) very few gastric lymphomas are associated with EBV; (3) not all low-grade gastric MALT lymphomas are H. pylori-dependent.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1008265829249
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