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  • Occupational Health and Environmental Toxicology  (3)
  • Polymer and Materials Science  (3)
  • Column liquid chromatography  (2)
  • [abr] pCMB; p-chloromercuric benzoate  (2)
Material
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 62 (1975), S. 176-183 
    ISSN: 0006-291X
    Keywords: [abr] SDS; sodium dodecylsulfate ; [abr] pCMB; p-chloromercuric benzoate
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 62 (1975), S. 176-183 
    ISSN: 0006-291X
    Keywords: [abr] SDS; sodium dodecylsulfate ; [abr] pCMB; p-chloromercuric benzoate
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Enantiomer separation ; Chiral ovomucoid column ; Diltiazem hydrochloride ; Clentiazem maleate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary A direct HPLC separation method was developed for the determination of the enantiomers of racemic precursors to diltiazem (I) and its 8-chloro derivatives (II). The enantiomers were successfully separated on a chiral ovomucoid column using an aqueous-organic mobile phase (reversed-phase HPLC). The influence of the organic modifier and buffer pH on the retention and enantioselectivity was investigated. The chromatographic conditions chosen for the separation permitted complete resolution of the enantiomers of both the acid (Ib and IIb) and methyl ester precursors (Ia and IIa) within 20 min. The influence of sample load on retention times, theoretical plates numbers, peak heights and peak areas was also investigated. The peak areas showed a good linearity over the concentration range examined, although all the others were influenced significantly by the sample size. An optical antipode of the intermediate to be determined could be detected by the area-percentage method down to ca. 0.1%, together with the determination of its precursor, including its optical purity.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    New York : Wiley-Blackwell
    Die Makromolekulare Chemie 178 (1977), S. 3191-3195 
    ISSN: 0025-116X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Optimized syntheses of 1,3,6,9-tetraoxacycloundecane (2), 1,3,6,9,12-pentaoxacylotetradecane (3), and 1,3,6,9,12,14,17,20-octaoxacyclodocosane (4) as well as some physical and chemical properties and the proof of structure are reported.
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part A: Polymer Chemistry 25 (1987), S. 2281-2288 
    ISSN: 0887-624X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Ethynylated polystyrene resins were prepared as functionalized polymer supports by the iodination reaction of macroporous polystyrene resins and reacted with transition metal diethynyl complex (Mt = Ni) and metal halides (Mt = Rh, Pd, and Pt) in a basic solvent using cuprous iodide as a catalyst to obtain macroporous polystyrene resins containing organotransition metals. The distribution of the metal acetylide complexes in the modified macroporous resins was determined by an electron probe microanalyzer. A gradient in the transition metal distribution was observed in any case of the modified resins. The stability of the organotransition metal complexes in the polymer matrix could be compared with a low molecular weight analogous complex quantitatively.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Enantiomer separation ; Denopamine ; Derivatization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary A reversed-phase high-performance liquid chromatographic (HPLC) method was developed to determine the optical purity of denopamine, which is a new cardiotonic agent having an asymmetric carbon in a molecule. The enantiomers were converted to diastereomeric thiourea derivatives using 2,3,4,6-Tetra-O-acetyl-β-D-glucopyranosyl isothiocyanate (GITC) reagent. Separation of the enantiomers of denopamine as diastereomers was successfully achieved by reversed-phase HPLC within 10 min using an ODS column and UV detection. Derivatization of denopamine proceeded rapidly under the alkaline conditions and the ambient temperature. This method was applied to the determination of the optical purity of denopamine drug substances and those in tablets. The favorable UV absorption of the derivatives enabled the optical antipode to be determined down to the 0.2% level.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 45 (1992), S. 1463-1472 
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The spherical tannin resin (STR) resulting from the reaction between Mimosa (Acacia Mollissima) tannin (condensed-type tannin) and formaldehyde was very porous. The specific surface area of the STR made from 37.5% of tannin was 139.2 m2/g (1 g of the resin in this is wet resin corresponding to 1 g of dried resin). Properties such as specific surface area and average pore radius could be controlled by adjusting the tannin concentration. The apparent activation energy of Cu2+ ion adsorption by STR was 3 kcal/mol, and that of Cr6+ ion was 2 kcal/mol. Since the energy was small, we concluded that the adsorption of metal ions was not influenced significantly by the adsorption temperature. The heat of adsorption for Cu2+ ions was only 1.6 kcal/mol, which suggests that the adsorption was a physical phenomenon. It was thought that the diffusion of heavy-metal ions into the porous resin was the rate-determining step of the adsorption since the elution profile of the column method was analogous to the profile of active carbon, which adsorbs physically, the heavy metal ions gradually leaking through the column. The surface and cross section of the STR were observed before and after Cu2+ ion adsorption with the scanning electron microscope. The pores of the spherical resin were clogged with adsorbed copper, suggesting that the Cu2+ ions were adsorbed during the formation of a multimolecular layer. The adsorption may therefore have been due to physical attractive forces. The rate of adsorption and adsorption isotherms of Cu2+ ions from copper salts having various anions was found to vary depending on the type of anion. These phenomena were not thought to be due to the properties of the spherical resin but to differences in the hydration state of copper ions.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Bioelectromagnetics 17 (1996), S. 21-32 
    ISSN: 0197-8462
    Keywords: blood flow ; static magnetic field ; magnetohydrodynamic interactions ; finite element analysis ; sinuatrial node ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
    Notes: The flow of blood in the presence of a magnetic field gives rise to induced voltages in the major arteries of the central circulatory system. Under certain simplifying conditions, such as the assumption that the length of major arteries (e.g., the aorta) is infinite and that the vessel walls are not electrically conductive, the distribution of induced voltages and currents within these blood vessels can be calculated with reasonable precision. However, the propagation of magnetically induced voltages and currents from the aorta into neighboring tissue structures such as the sinuatrial node of the heart has not been previously determined by any experimental or theoretical technique. In the analysis presented in this paper, a solution of the complete Navier-Stokes equation was obtained by the finite element technique for blood flow through the ascending and descending aortic vessels in the presence of a uniform static magnetic field. Spatial distributions of the magnetically induced voltage and current were obtained for the aortic vessel and surrounding tissues under the assumption that the wall of the aorta is electrically conductive. Results are presented for the calculated values of magnetically induced voltages and current densities in the aorta and surrounding tissue structures, including the sinuatrial node, and for their field-strength dependence. In addition, an analysis is presented of magnetohydrodynamic interactions that lead to a small reduction of blood volume flow at high field levels above approximately 10 tesla (T). Quantitative results are presented on the offsetting effects of oppositely directed blood flows in the ascending and descending aortic segments, and a quantitative estimate is made of the effects of assuming an infinite vs. a finite length of the aortic vessel in calculating the magnetically induced voltage and current density distribution in tissue. © 1996 Wiley-Liss, Inc.
    Additional Material: 12 Ill.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Bioelectromagnetics 5 (1984), S. 399-410 
    ISSN: 0197-8462
    Keywords: magnet ; magnetic field ; tissue culture ; exposure system ; biological effects ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
    Notes: A magnetic field generator constructed of rare earth-cobalt magnets is proposed for examining the biological effects of static magnetic fields (less than 1 T) on tissue cultures. Important quantities of a magnetic field from a biological-effects viewpoint, ie, its strength and the product of strength and gradient, are analysed. A practical procedure for designing the generator with optimum parameters is given. Also, parameters are determined which will yield a sinusoidal spatial field distribution.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Bioelectromagnetics 9 (1988), S. 159-166 
    ISSN: 0197-8462
    Keywords: Lorentz force ; Maxwell stress ; threshold field strength ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
    Notes: Static magnetic fields affect the diffusion of biological particles in solutions through the Lorentz force and Maxwell stress. These effects were analyzed theoretically to estimate the threshold field strength for these effects. Our results show that the Lorentz force suppresses the diffusion of charged particles such as Na+, K+, Ca2+, Cl-, and plasma proteins. However, the threshold is so high, i.e., more than 104 T, that the Lorentz force does not affect the ion diffusion at typical field strengths (a few Tesla at most). Since the threshold of gradient fields for producing a change in ion diffusion through the Maxwell stress is more than 105 T2/m for paramagnetic molecules (FeCl3, O2) and plasma proteins, their diffusion would be unaffected by typical gradient fields (100 T2/m at most) and even by high gradient fields (less than 105 T2/m) used in magnetic separation techniques. In contrast, movement of deoxygenated erythrocytes and FeCl3 colloids (more than 103 molecules) is influenced by the usual gradient fields due to a volume effect.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
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