ISSN:
1432-2072
Keywords:
Tetrabenazine
;
Imipramine
;
Antidepressants
;
Conditional
;
Reflex Activity
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The tetrabenazine-imipramine interaction has been studied on a discrete-trial avoidance escape schedule in rats. In a large dose, imipramine (30 mg/kg i.p.) failed to antagonize the 10 mg/kg s.c. tetrabenazine-induced behavioural depression. 3.0–6.0 mg/kg imipramine +0.5 mg/kg tetrabenazine induced a statistically significant depression, while the same drugs alone (in similar dose) had no significant effect on responding. The depressant action of 1.0 mg/kg tetrabenazine was potentiated by imipramine pretreatment.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00429131
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