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  • Controlled-release formulation  (1)
  • Glutathione  (1)
  • PP  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Extracellular glutathione and γ-glutamyl transpeptidase prevent H"2O"2-induced injury by 2,3-dimethoxy-1,4-naphthoquinone
    Amsterdam : Elsevier
    Free Radical Biology and Medicine 15 (1993), S. 57-67 
    Details
    ISSN: 0891-5849
    Keywords: Free radicals ; Glutathione ; Oxidative stress ; Quinone ; γ-Glutamyl transpeptidase
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0891-5849(93)90125-E
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Relative potency of controlled-release oxycodone and controlled-release morphine in a postoperative pain model (1999)
    Springer
    European journal of clinical pharmacology 55 (1999), S. 425-429 
    Details
    ISSN: 1432-1041
    Keywords: Key words Oxycodone ; Morphine ; Controlled-release formulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Objective: The relative analgesic potency of single doses of oral controlled-release oxycodone and oral controlled-release morphine were compared in a randomized, double-blind trial using a postoperative pain model. Methods: Women (n = 169) with moderate to severe pain following abdominal hysterectomy received single oral doses of controlled-release oxycodone, 20 mg or 40 mg, or controlled-release morphine, 45 mg or 90 mg. Assessments were made at 30 min, 60 min, then hourly after dosing for 12 h or until remedication. Results: The most precise estimates of relative potency showed that controlled-release oxycodone was 1.8 times more potent than controlled-release morphine for total effect (95% confidence limits 1.09–2.42; lambda 0.44) and 2.2 times more potent for peak effect (95% confidence limits 0.96–4.59; lambda 0.71). Controlled-release oxycodone at doses of 20 mg or 40 mg was comparable with controlled-release morphine at doses of 45 mg or 90 mg, respectively, for total and peak analgesic effects. For the two higher doses, time to peak relief was approximately 1 h shorter with controlled-release oxycodone than with controlled-release morphine. Most patients reported onset of analgesia within 1 h with all doses. Side effects were similar with the two opioids. Conclusion: Oral controlled-release oxycodone was twice as potent as oral controlled-release morphine in this single-dose, relative potency assay. When converting patients from oral morphine to oral oxycodone, an initial oral oxycodone dose of one-half the oral morphine dose is recommended.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002280050651
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Polymer treatment in the flowing afterglow of an oxygen microwave discharge: Active species profile concentrations and kinetics of the functionalization (1995)
    Springer
    Plasma chemistry and plasma processing 15 (1995), S. 173-198 
    Details
    ISSN: 1572-8986
    Keywords: Singlet molecular oxygen ; atomic oxygen ; flowing afterglow ; downstream reactor ; microwave discharge ; PP ; PF ; PC ; hexatriacontane ; octadecyloctadecanoate ; functionalization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Technology
    Notes: Abstract The surface treatment of different polymers and their corresponding model surfaces in the flowing afterglow of an oxygen microwave plasma is investigated. The concentration profiles of tire long-lived species issued from the plasma are measured and calculated in the downstream area The influence of atomic and singlet molecular oxygen in the behavior of different polymers is investigated. It appears that the evolution of the surface energy can be explained by an initiation of the functionalization by the oxygen atoms impinging upon the surface followed by reaction of the radicals formed with molecular oxygen. The concentration of functions at the sureface is limited due to their destruction by reaction with oxygen atoms. Furthermore, the functionalization level is higher in the /lowing afterglow than in the plasma, without any significant degradation of the polymer surface. Therefore, the treatment in the flowing afterglow is more efficient to increase suface energy in particular, for polymers which undergo high backbone chain scission.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01459695
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    Paper (German National Licenses)
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