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  • Copper  (1)
  • MRI  (1)
  • intracranial pressure rebound  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Rebound of ICP after brain compression (1990)
    Springer
    Acta neurochirurgica 104 (1990), S. 126-135 
    Details
    ISSN: 0942-0940
    Keywords: Magnetic resonance imaging ; intracranial mass lesion ; intracranial pressure rebound ; brain oedema
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The rebound of intracranial pressure (ICP) occurring after decompression of an intracranial mass lesion was studied in an epidural balloon compression model. Intracranial morphology and brain tissue water content were assessed with magnetic resonance imaging (MRI). Fast and slow components of the transverse relaxation time (T2) were used as indicators of brain oedema development. During balloon compression a progressive prolongation of both the fast and the slow T2 components took place. Following deflation of the balloon both components increased rapidly, particularly the slow-T2. The MR scans displayed progressive occlusion of the aqueduct, and obliteration of the ambient and pontine cisterns. The changes in morphology and in water content after decompression had largely the same time course as the development of the rebound of ICP. In contrast, no changes in morphology and tissue water content occurred after hydrostatic brain compression achieved by subarachnoid fluid infusion. The findings suggest that the intracranial pressure rebound is caused by cerebral oedema accumulated during and particularly in the recirculation phase after an ischaemic injury of adequate intensity and adequate duration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01842830
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Magnetic resonance imaging of the brain in Wilson's disease (1993)
    Springer
    Neuroradiology 35 (1993), S. 134-141 
    Details
    ISSN: 1432-1920
    Keywords: Wilson's disease ; Copper ; Chelating agents ; Magnetic resonance imaging ; Relaxation times
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Fifteen patients with Wilson's disease were examined, using spin-echo (SE) and gradient-echo (GE) sequences with 0.5 T and 1.5 T magnetic resonance (MR) imagers. They fell into three groups: groups 1 and 2 were examined retrospectively after 3–18 years of treatment, while group 3 was examined prospectively from the start of treatment, after recommencement of treatment, or inadequate treatment. MRI was sensitive to changes in the basal ganglia at sites typical of Wilson's disease and was useful for documenting the effects of treatment. It was found necessary to estimate the relaxation times T1 and T2, to better assess improvement or transient worsening of the disease in the prospective group. Residual cavitation and gliosis could be distinguished in the retrospective group using a subtraction technique.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00593970
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Long-term follow-up of patients with primary amyloidosis with MRI (1994)
    Springer
    European radiology 4 (1994), S. 452-457 
    Details
    ISSN: 1432-1084
    Keywords: MRI ; Amyloidosis ; Relaxation times ; Chemotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of chemotherapy on subjects with primary amyloidosis (AL-amyloidosis) were studied with MRI in five patients. The MRI was performed every 3–5 months for 23–60 months, and the T1 and T2 relaxation times were determined in liver and subcutaneous fat. In the patients as a whole T1 was significantly prolonged (P 〈 0.05), whereas T2 was within normal range. On follow-up with repeated MRI increasing T1 values could be measured in progressive disease (one patient) whereas decreasing T1 values seemed to parallel clinical improvements in four patients. The effect of different treatment schedules in AL-amyloidosis may be evaluated with MRI and the amount of amyloid deposits may be quantified.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00212820
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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