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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 125 (1977), S. 213-217 
    ISSN: 1432-1076
    Keywords: Reverse T3 ; Amniotic fluid ; Cord blood
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 3,3′,5′-Trijodthyronin (Reverse T3, rT3) wurde in 122 Frucht-wasserproben aus der 29.–40. Schwangerschaftswoche und im Blut von 37 Neugeborenen sowie deren Müttern bestimmt. Der mittlere rT3-Gehalt der Fruchtwasser lag bei 0,769±0,47 ng/ml; ein leichter Abfall der rT3-Konzentrationen bei steigendem Gestationsalter war statistisch nicht zu sichern. Aufgrund der großen Streuungen scheint das rT3 zur praenatalen Hypothyreosediagnostik ungeeignet. Die mittlere rT3-Konzentration im Nabelschnurblut von 2,62 ng/ml war gegenüber dem durchschnittlichen rT3-Spiegel der Mutter unter der Geburt von 0,34 ng/ml stark erhöht. Die mögliche Verwendung der rT3-Messung im Nabelschnurblut zum Hypothyreose-Screening wird diskutiert.
    Notes: Abstract 3,3′,5-triiodothyronine (reverse T3, rT3) was measured in 122 samples of amniotic fluid obtained between the 29th–40th weeks of gestation, and in the blood of 37 newborn and their mothers. The mean rT3 concentration in amniotic fluid was 0.769±0.47 ng/ml, with a slight decrease from the 29th–40th weeks of gestation which was not statistically significant. Because of the great scatter of rT3 concentrations in amniotic fluid, its estimation does not seem to be useful in prenatal diagnosis of hypothyroidism. The mean rT3 concentration in cord blood (2.62 ng/ml; range 1.4–4.9 ng/ml) was greatly elevated in comparison to the mean maternal level at delivery (0.34 ng/ml; range 0.08–0.69 ng/ml). The possible use of rT3 measurements in cord blood as a screening test for congenital hypothyroidism is discussed.
    Type of Medium: Electronic Resource
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