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  • 1
    Electronic Resource
    Electronic Resource
    Serum α1-microglobulin and β2-microglobulin for the estimation of fetal glomerular renal function (1991)
    Springer
    Pediatric nephrology 5 (1991), S. 573-577 
    Details
    ISSN: 1432-198X
    Keywords: α1-Microglobulin ; β2-Microglobulin ; Creatinine ; Neonate ; Fetal kidney function
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract As proteins cannot cross the placenta levels of the microproteins α1-microglobulin (α1MG) and β2-microglobulin (β2MG) can be used to assess fetal glomerular renal function. α1MG, β2MG and creatinine were routinely determined in cord and maternal blood of 133 newborns [gestational age (GA) 25–42 weeks]. Twenty-nine patients with suspected impaired maternal or fetal renal function were studied separately and two fetuses were studied in utero. The mean fetal β2MG concentration fell from 3.87±0.56 mg/l in the 25–31 weeks GA group to 2.60±0.50 mg/l in the mature newborn group. α1MG concentration fell from 3.10±0.51 to 2.25±0.49 mg/dl. In contrast, the mean maternal β1MG concentration rose from 1.73±0.69 mg/l in the 25–31 weeks GA group to a mean of 1.83±0.48 mg/l in the mature newborn group; α1MG rose from 3.96±0.58 to 4.33±1.6 mg/dl. Maternal and fetal creatinine levels were identical. Fetal microprotein levels fall during intra-uterine development as glomerular filtration rate (GFR) rises. There is no correlation between cord blood and maternal α1MG or β2MG concentrations. In 13 children with urological anomalies only 1 had elevated microprotein levels and he later developed renal insufficiency. Determination of microprotein levels in fetal serum can be used to detect severe renal function disturbances and to estimate GFR independently of maternal renal function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00856641
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Dysplastic features, growth retardation, malrotation of the gut, and fatal ventricular septal defect in a 4-month-old girl with ring chromosome 15 (1984)
    Springer
    European journal of pediatrics 142 (1984), S. 229-231 
    Details
    ISSN: 1432-1076
    Keywords: Chromosomal aberration ; Ring chromosome 15 ; Dysplasias ; Malformations ; Ventricular septal defect
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A 20-day-old female neonate was admitted with symptoms caused by a large ventricular septal defect which was subsequently confirmed angiographically. Other clinical findings were pre-and postnatal growth retardation, microcephaly, dysmorphism of ears, fingers and feet. Cytogenetic analysis revealed a ring chromosome 15. Despite a palliative banding operation of the pulmonary artery, the infant succumbed to complications of her congenital heart disease in the 4th month of life.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00442457
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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