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  • 1
    Electronic Resource
    Electronic Resource
    Reduction of calcium excretion in the stone-forming kidney in unilateral ureteral obstruction (1991)
    Springer
    Urological research 19 (1991), S. 193-198 
    Details
    ISSN: 1434-0879
    Keywords: Urolthiasis ; Obstructive uropathy ; Percutaneous nephrostomy ; Hypercalciuria ; Creatinine clearance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Thirteen urolithiasis patients with unilateral obstructive uropathy were treated with percutaneous nephrostomy (PCN) either for urinary diversion, endopyelotomy, nephrolithtotmy or chemolysis. After percutaneous nephrostomy, the indvidual urine volume, creatinine clearance (Ccr), urinary absolute and fractional excretions of sodium, potassium, calcium, magnesium and inorganic phosphate were measured separately in timed urine collections from a pigtail catheter and from the urethra. The data showed that Ccr and the absolute urinary excretions of sodium, potassium, calcium, magnesium and inorganic phosphate were significantly lower in the PCN kidney immediately or 2 days after relief of obstruction. The ratio of total urinary calcium excretion to urinary creatinine excretion in the obstructed kidney was significantly greater than that in the contralateral kidney. The fractional excretions of calcium and magnesium increased as renal function decreased. The results showed that when the total Ccr is below normal, the apparent excretion of urinary calcium will be underestimated. However, when the total Ccr of patients is within normal range, hypercalciuria may be detected adequately and thus favors early implementation of an appropriate therapeutic strategy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00303749
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Allopurinol blocks shock-wave-induced rises in cytosolic calcium levels in MDCK cells (1997)
    Springer
    Urological research 25 (1997), S. 427-432 
    Details
    ISSN: 1434-0879
    Keywords: MDCK cells ; Allopurinol ; Shock waves ; Lithotripsy ; Calcium signalling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Allopurinol has been reported to ameliorate the side effects in patients following shock wave lithotripsy (SWL); however, the mechanism has not been studied. We have examined the protective effect of allopurinol on Madin-Darby canine kidney (MDCK) cells after shock wave exposure (SWE) by determining the release of aspartate aminotransferase (ASAT) and lactate dehydrogenase (LD), and the resting cytosolic Ca2+ concentration ([Ca2+]i). In SWE-treated cells, the release of ASAT and LD increased immediately, but largely transiently, by approximately 23% and 5-fold over control, respectively. Within 1–6 h after SWE there was a gradual rise in the resting [Ca2+]i of 16–137% above control. Allopurinol did not affect the transient enzyme release but blocked the long-term rises in the resting [Ca2+]i. The transient changes in [Ca2+]i evoked by two hormones, ATP and bradykinin, and a drug that releases Ca2+ from internal Ca2+ stores, thapsigargin, were only slightly affected in allopurinol-treated cells. We conclude that the protection conferred by allopurinol on patients treated with SWL might involve a direct protection of the kidney cells by maintaining a normal resting [Ca2+]i.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01268861
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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