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  • Cryotherapy  (1)
  • EEG spectral analysis  (1)
  • Key words Cutis marmorata telangiectatica congenita  (1)
  • Key words Multiple sclerosis  (1)
Source
Material
Years
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Granuloma eosinophilicum faciei – erfolgreiche kryochirurgische Behandlung bei sechs Patienten (1998)
    Springer
    Der Hautarzt 49 (1998), S. 477-481 
    Details
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Granuloma eosinophilicum faciei ; Granuloma faciale ; Kryotherapie ; Kryochirurgie ; Key words Granuloma eosinophilicum faciei ; Granuloma faciale ; Cryotherapy ; Cryosurgery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Six patients with granuloma faciale, including patients with multiple lesions, were treated successfully with cryosurgery. Granuloma faciale is known to be difficult to treat. Cryosurgery is an effective and minimally invasive therapy for this granulomatous inflammation of the skin. It should be considered as an alternative to dapsone.
    Notes: Zusammenfassung Sechs Patienten mit Granuloma eosinophilicum faciei, darunter auch Patienten mit multiplen Läsionen, wurden mit Erfolg kryochirurgisch behandelt. Das Granuloma eosinophilicum faciei ist gegenüber vielen Behandlungsformen therapieresistent. Die Kryotherapie stellt eine wirksame und wenig belastende Behandlung für diese granulomatöse Entzündung dar. Sie sollte als Therapiealternative gegenüber einer systemischen Behandlung mit Dapson erwogen werden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001050050773
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Binding characteristics of the glucocorticoid receptor in peripheral blood lymphocytes in multiple sclerosis (1999)
    Springer
    Journal of neurology 246 (1999), S. 292-298 
    Details
    ISSN: 1432-1459
    Keywords: Key words Multiple sclerosis ; Lymphocytes ; Glucocorticoid ; receptors ; Dexamethasone CRH test
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Although the exact etiology of multiple sclerosis (MS) remains unresolved, immune reactions are believed to be the central pathogenic mechanisms. Endogenous and therapeutic steroid hormones affect the immune system, and inflammatory diseases are associated with activation of the hypothalamic-pituitary-adrenal axis, providing evidence of an immune-endocrine interplay. Function tests in MS have revealed dysregulation of the hypothalamic-pituitary-adrenal system in a substantial proportion of patients. We characterized glucocorticoid receptor (GR) binding in peripheral blood lymphocytes from 39 MS patients and 14 age- and sex-matched controls with respect to dissociation constant and binding capacity, using a whole-cell binding assay with [3H]dexamethasone as the ligand. GR binding parameters did not differ significantly between patients (K d 8.98 ± 1.07 nM, B max 183 ± 29.8 fmol/mg) and controls (K d 9.36 ± 1.17 nM, B max 158 ± 16 fmol/mg). No effect of age, sex, course, duration or severity of disease, or prior steroid treatments was detected. GR binding parameters were analyzed in relation to the results of the combined dexamethasone-CRH test, which reflects corticosteroid receptor function at the hypothalamus, in 30 patients and 9 controls. While controls showed a moderate correlation between binding affinity of the GR in lymphocytes and regulatory function at the hypothalamic level, the patients did not. These data suggest that the physiological relationship between binding and function of the glucocorticoid receptor is disturbed in MS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004150050349
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Cutis marmorata teleangiectatica congenita Wichtige Aspekte für die dermatologische Praxis (1997)
    Springer
    Der Hautarzt 48 (1997), S. 21-25 
    Details
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Cutis marmorata teleangiectatica congenita ; van Lohuizen-Syndrom ; Angeborene Fehlbildungen ; Key words Cutis marmorata telangiectatica congenita ; van Lohuizen syndrome ; Congenital anomalies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Cutis marmorata telangiectatica congenita (van Lohuizen) is a rare skin disease in newborn or very young children. From the dermatological point of view, therapy is either not necessary or uncomplicated. However, the dermatologist and/or the pediatrician need to search for possibly associated anomalies. Clinical characteristics of 15 patients examined in the Fachklinik Hornheide within the last 11 years are presented. By giving a survey of the anomalies associated with cutis marmorata telangiectatica congenita, we demonstrate the need of neuropediatric, ophthalmologic and orthopedic examinations in addition the pedriatic and dermatologic examinations.
    Notes: Zusammenfassung Die Cutis marmorata teleangiectatica congenita (van Lohuizen) ist eine seltene Hautkrankheit bei Neugeborenen oder Säuglingen. Aus rein dermatologischer Sicht ist eine Therapie meist nicht notwendig oder unkompliziert. Dem Hautarzt kommt aber zusammen mit dem Pädiater die zusätzliche Aufgabe zu, die Abklärung möglicher assoziierter Fehlbildungen zu veranlassen. Klinische Charakteristika von 15 in den letzten 11 Jahren in der Fachklinik Hornheide untersuchten Patienten werden beschrieben und anhand einer Übersicht der fakultativ mit der Cutis marmorata teleangiectatica congenita assoziierten Fehlbildungen die Notwendigkeit dargestellt, bei jedem Patienten neben kinderärztlichen und dermatologischen auch spezielle kinderneurologische, augenärztliche und orthopädische Untersuchungen vorzunehmen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001050050541
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    The GABAA receptor antagonist picrotoxin attenuates most sleep changes induced by progesterone (1999)
    Springer
    Psychopharmacology 141 (1999), S. 213-219 
    Details
    ISSN: 1432-2072
    Keywords: Key words Neurosteroids ; GABAA receptor ; Sleep ; EEG spectral analysis ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Progesterone has been shown to exert benzodiazepine-like effects on sleep, which suggests that they are mediated by an agonistic modulation of GABAA receptor functioning. To assess the involvement of GABAA receptors, we investigated the sleep responses to one dose of the GABAA antagonist picrotoxin (1.5 mg/kg) and progesterone (90 mg/kg), administered IP to eight rats alone and in combination, during the first 4 post-injection hours. Compared with vehicle, picrotoxin significantly delayed the latency to non-rapid eye movement sleep (non-REMS) and thereby decreased all sleep states, but barely affected the EEG activity within non-REMS. Progesterone significantly shortened non-REMS latency, increased pre-REMS, depressed low-frequency EEG activity (≤8 Hz) and augmented EEG activity in the higher frequencies within non-REMS. Except for the changes in high-frequency EEG activity, picrotoxin attenuated all effects of progesterone. These findings support the notion that GABAA receptors play an important role in the sleep effects of progesterone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002130050827
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    Paper (German National Licenses)
    Fulltext
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