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  • 1
    Digitale Medien
    Digitale Medien
    The succinate dehydrogenase inhibition test for evaluating biopsy specimens and resected tumors of advanced gastric cancer (1992)
    Springer
    Surgery today 22 (1992), S. 508-511 
    Details
    ISSN: 1436-2813
    Schlagwort(e): SDI test ; chemosensitivity test ; MTT assay ; antitumor drug ; gastric cancer
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract An in vitro chemosensitivity study of both biopsy specimens and surgically resected tumors of advanced gastric cancer from 12 patients was evaluated using the succinate dehydrogenase inhibition (SDI) test. A decrease in succinate dehydrogenase (SD) activity as an indicator of chemosensitivity was determined using cisplatin (CDDP), etoposide (VP-16), and mitomycin C (MMC). In this study, 29 of a total 36 experiments were evaluable (80.6%) and significant correlations were found in all three of the antitumor drugs (P〈0.03). This finding suggests that the SDI test using biopsy specimens may prove valuable for assessing the preoperative chemosensitivity of advanced gastric cancer.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00308895
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  • 2
    Digitale Medien
    Digitale Medien
    Proliferation-associated nuclear antigen p105 as a marker for metastasis of human gastric cancer (1991)
    Springer
    Journal of cancer research and clinical oncology 117 (1991), S. 583-586 
    Details
    ISSN: 1432-1335
    Schlagwort(e): Proliferation-associated nuclear antigen ; p105 ; gastric cancer ; metastasis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The expression of the proliferation-associated nuclear antigen p105 in 43 patients with advanced gastric carcinoma was studied by multiparameter flow cytometry. The p105 immunofluorescence intensity of tumor cells in the G0G1 phase was 1.8–14.5 times that in stromal cells, and the stromal cells could be separated by flow cytometry. The p105 intensity, which is the ratio of the mean fluorescence intensity of cancer cells to that of stromal cells in the G0G1 phase, was not correlated with the DNA index, the size of the S-phase fraction, or the histological type of the tumor. However, the intensity was significantly greater in patients with hepatic metastasis and significantly lower in patients with peritoneal metastasis. The patients with a p105 intensity of 4.0 or more had a significantly higher incidence of hepatic metastasis (8/22; 36%). The patients with a p105 intensity of less than 4.0 had a significantly higher incidence of peritoneal metastasis (8/21; 38%). These results suggest that the p105 intensity is a marker of metastasis useful in the treatment and follow-up of patients.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01613292
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  • 3
    Digitale Medien
    Digitale Medien
    Membrane-type 1 matrix metalloproteinase enhances lymph node metastasis of gastric cancer (2000)
    Springer
    Clinical & experimental metastasis 18 (2000), S. 321-327 
    Details
    ISSN: 1573-7276
    Schlagwort(e): gastric cancer ; lymph node metastases ; MT1-MMP ; NMP-2
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The mechanisms of the lymph node metastasis remain unclear. We demonstrate the role of MT1-MMP on the lymph node metastasis using in vivo experimental model of lymph node metastasis by orthotopic implantation of MT1-MMP transfected gastric cancer cell line in the stomach of nude rats. TMK-1 cell line without expression of MT1-MMP was transfected with the pcDNA3 plasmid containing a 3.4-kb MT1-MMP cDNA fragment by calcium phosphate method, and the transfected cell line was designated as TMK-MT. Western blot and RT-PCR analyses showed the specific bands corresponding to MT1-MMP in the TMK-MT cells. By gelatin zymography, the activated form (62-kDa) of MMP-2 was identified in the medium of TMK-MT cell line, but was not detected in TMK-1 cells. Six weeks after orthotopic implantation of TMK-1 and TMK-MT xenografts of nude mouse-subcutaneus tumor into the stomach of nude rats, gastric tumors were found in all the animals. Histologically, the lymphatic invasion was found in the submucosa of the TMK-MT gastric tumors. Lymph node metastasis was not detected in nude rats bearing TMK-1 gastric tumor (0/8). In contrast, lymph node metastasis was detected in five out of 8 rats, bearing TMK-MT gastric tumor. MT1-MMP immunoreactivity was found on the cell membrane and cytoplasm of TMK-MT cells not only in the lymph node metastasis but also in the stomach tumor. These results suggest that MT1-MMP overexpression induced by transfection of its gene may promote lymph node metastasis of transformed cells.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1010887014669
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  • 4
    Digitale Medien
    Digitale Medien
    Constituents of holothuroidea, II. Six newly identified biologically active triterpenoid glycoside sulfates from the sea cucumber Cucumaria echinata (1990)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1990 (1990), S. 453-460 
    Details
    ISSN: 0170-2041
    Schlagwort(e): Cucumaria echinata ; Sea cucumber ; Cucumariidae ; Triterpenoid glycoside sulfate ; Holostane derivative ; Chemistry ; Organic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: From the whole body of sea cucumber Cucumaria echinata (Cucumariidae), we recently identified six genuine holostane-type triterpenoid glycoside sulfates designated as cucumechinoside A (1), B (2), C (3), D (4), E (5), and F (6). The structures 1-6 were determined on the basis of chemical and spectral investigations. Antitumor activities of these cucumechinosides and their solvolized compounds (10, 11, and 12) against murine lymphoma L 1210 and human epidermoid carcinoma KB cell in vitro were examined, and their antifungal and antiprotozoal activities were also investigated.
    Zusätzliches Material: 4 Tab.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jlac.199019900186
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