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  • Cyclic AMP  (1)
  • Familial adenomatous polyposis  (1)
  • 1
    ISSN: 1530-0358
    Keywords: Colitis ; Familial adenomatous polyposis ; Restorative proctocolectomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract PURPOSE: This study was undertaken to identify the optimum level of stapled ileal pouch-anal anastomosis. METHOD: A prospective, randomized trial was completed to compare double-stapled ileoanal anastomosis placed at the top of anal columns (high, n=26) with anastomosis at the dentate line (low, n=21). RESULTS: There was no significant difference in the overall complication rate between operations (high, n=7,vs. low, n=8; P〈0.21). Pouchanal functional score (scale 0–12; 0=excellent, 12=poor) was significantly better in the high anastomosis group (median (range): 2 (1–9) vs. 5.5 (1–12); P〈0.05). Incontinence occurred in only two patients randomized to high anastomosis compared with six in the low anastomosis group. Nocturnal soiling was reported in three patients after high anastomosis and in six patients after dentate line anastomosis. Both operations caused a significant but comparable reduction of maximum anal resting pressure (31 percent after high anastomosis (P〈0.05); 23 percent after low anastomosis (P〈0.05)). However, a significant fall in functional length of the anal canal was only seen after a low pouch-anal anastomosis (P〈0.05). CONCLUSION: Stapled pouch-anal anastomosis at the top of anal columns gives better functional results compared with a stapled anastomosis at the dentate line.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 51 (1995), S. 1166-1174 
    ISSN: 1420-9071
    Keywords: Cyclic AMP ; receptors ; adenylyl cyclase ; phosphodiesterase ; protein kinase ; cAMP analogs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract cAMP plays an essential role duringDictyostelium development both outside and inside the cell. Membrane-bound receptors and adenylyl cyclase are responsible for sensing and producing extracellular cAMP, whereas a phosphodiesterase is responsible for maintaining a low basal level. The molecular events underlying this type of hormone like signalling, which are now beginning to be deciphered, will be presented, in the light of cAMP analogue studies. The importance of intracellular cAMP for cell differentiation has been demonstrated by the central role of the cAMP dependent protein kinase. Mutants as well as strains obtained by reverse genetics will be reviewed which lead to our current understanding of the role of intracellular cAMP in the differentiation of both stalk and spore cells.
    Type of Medium: Electronic Resource
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