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  • Cyclic AMP  (1)
  • cyclic AMP  (1)
  • insulin β2-adrenergic agonists  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Actions of salbutamol in late pregnancy: Plasma cyclic AMP, insulin and C-peptide, carbohydrate and lipid metabolites in diabetic and non-diabetic women (1978)
    Springer
    Diabetologia 14 (1978), S. 235-242 
    Details
    ISSN: 1432-0428
    Keywords: Cyclic AMP ; insulin β2-adrenergic agonists ; diabetes ; pregnancy and metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Salbutamol was administered intravenously in doses increasing from 3.75 to 22.5 μg/min to 5 non-diabetic and 7 diabetic women in the last trimester of pregnancy. In diabetic as well as nondiabetic women the diastolic blood pressure fell progressively with increasing doses, and the systolic BP and heart rate increased at doses above 7.5 μg/min. The effect on fetal heart rate was less pronounced than the effect on maternal heart rate. Cyclic AMP levels in plasma were similar in non-diabetic and diabetic women before salbutamol. Twenty min following 3.75 μg/min a significant increase was seen in both groups. The peak increase (3–5 fold) was higher in the diabetic than in the non-diabetic women. Plasma insulin and C-peptide levels rose in a dose-dependent manner in the non-diabetic and four of the diabetic women. However, in three of the diabetic women the insulin level was unaffected by salbutamol and C-peptide was almost undetectable. Plasma concentrations of glucose, glycerol, NEFA and 3-HB were higher in the diabetics than in the non-diabetics before salbutamol and the elevations induced by salbutamol were also significantly larger in the diabetic women. The present data show that salbutamol in doses employed clinically may cause pronounced metabolic effects, especially in diabetic women, and it is suggested that when intravenous infusion of salbutamol is given to pregnant diabetic women not only cardiovascular but also some metabolic variable such as glucose should be carefully monitored.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01219422
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Metabolic effects of oral salbutamol in late pregnancy (1978)
    Springer
    European journal of clinical pharmacology 14 (1978), S. 95-99 
    Details
    ISSN: 1432-1041
    Keywords: Salbutamol ; metabolic effects ; cyclic AMP ; β-adrenergic agonist ; pregnancy ; carbohydrate metabolism ; lipid metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Ten women in late pregnancy were given an oral dose of salbutamol 4 mg. Heart-rate and blood-pressure were recorded and blood-samples for measurement of cyclic AMP, C-peptide, glucose, lactate, glycerol, non-esterified fatty acids (NEFA) and β-hydroxybutyrate (3-HB) were collected every 30 min for 120 min. In seven of the women the same experiment was performed without the salbutamol. After salbutamol maternal heart-rate was significantly increased at 30 and 90 min, and diastolic blood-pressure was significantly decreased between 30 and 120 min; systolic blood-pressure was unaltered. Plasma cyclic AMP was significantly increased by salbutamol at 30 and 120 min and C-peptide at 60 min. Plasma glucose was significantly elevated 60 min after salbutamol and glycerol after 90 min. Plasma NEFA and 3-HB increased both with and without the drug, with a tendency towards higher levels in the group that received salbutamol. Lactate levels were unchanged after salbutamol and fell when the drug was not given, but the difference was not significant. The results show clear circulatory and metabolic effects of a single clinical dose of salbutamol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00607438
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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