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  • Magnetic resonance imaging  (2)
  • Cyclophosphamide  (1)
  • Experimental allergic encephalomyelitis  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Long echo time STIR sequence MRI of optic nerves in optic neuritis (1996)
    Springer
    Neuroradiology 38 (1996), S. 66-69 
    Details
    ISSN: 1432-1920
    Keywords: Magnetic resonance imaging ; Optic neuritis ; Multiple sclerosis ; Visual evoked potentials
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract MRI of the optic nerves was obtained in 13 patients with acute optic neuritis and 13 with a previous optic neuritis (ON), assessed by clinical features, visual fields and visual evoked potentials. Results of the conventional short tau inversion recovery (STIR) sequence obtained with a short echo time (STE-STIR; 22 ms) were compared with those of a long echo time (LTE-STIR: 80 ms) sequence. The conventional STE-STIR sequence revealed lesions in the optic nerves in 78.5% of acute and 58.8% of previous ON. The LTE-STIR sequence showed abnormalities in 92.8% of acutely symptomatic nerves and 94.1% of nerves with previous ON. The optic nerve lesions appeared significantly longer with the LTE-STIR sequence than with the conventional STE-STIR sequences, in both acute and previous ON.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00593226
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Randomized placebo-controlled trial of mitoxantrone in relapsing-remitting multiple sclerosis: 24-month clinical and MRI outcome (1997)
    Springer
    Journal of neurology 244 (1997), S. 153-159 
    Details
    ISSN: 1432-1459
    Keywords: Key words Multiple sclerosis ; Mitoxantrone ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We designed a randomized, placebo-controlled, multicentre trial involving 51 relapsing-remitting multiple sclerosis patients to determine the clinical efficacy of mitoxantrone treatment over 2 years. Patients were allocated either to the mitoxantrone group (27 patients receiving IV infusion of mitoxantrone every month for 1 year at the dosage of 8 mg/m2) or to the placebo group (24 patients, receiving IV infusion of saline every month for 1 year) using a centralized randomization system. Disability at entry and at 12–24 months was evaluated by four blinded neurologists trained in the application of the Kurtzke Expanded Disability Scale (EDSS). In addition, the number and clinical characteristics of the exacerbations over the 24 months were recorded by the local investigators. MRI, at 0,12 and 24 months, was performed with a 0.2 T permanent unit. MRI data were analysed by two blinded neuroradiologists. All patients underwent a clinical evaluation. A statistically significant difference in the mean number of exacerbations was observed between the mitoxantrone group and placebo group both during the 1st and the 2nd year. Although there was no statistically significant benefit in terms of mean EDSS progression over 2 years, the proportion of patients with confirmed progression of the disease, as measured by a one point increase on the EDSS scale, was significantly reduced at the 2nd year evaluation in the mitoxantrone group. Forty-two (23 mitoxantrone, 19 placebo) patients underwent all MRI examinations during the 24-month period. We observed a trend towards a reduction in the number of new lesions on T2-weighted images in the mitoxantrone group. Our study suggests that mitoxantrone might be effective in reducing disease activity, both by decreasing the mean number of exacerbations and by slowing the clinical progression sustained by most patients after 1 year from the end of treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004150050066
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Evoked potential (EP) alterations in experimental allergic encephalomyelitis (EAE): early delays and latency reductions without plaques (1996)
    Springer
    Neurological sciences 17 (1996), S. 23-33 
    Details
    ISSN: 1590-3478
    Keywords: Evoked potentials ; Experimental allergic encephalomyelitis ; Multiple sclerosis ; Demyelination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario Ventiquattro cavie di ceppo 13 sono state sensibilizzate con omogenato di midollo spinale autologo in adiuvante di Freund, al fine di indurre un'Encefalite Allergica Sperimentale (EAE) nelle forme Cronica Recidivante (CR-EAE), Cronica Progressiva (CP-EAE) ed Acuta (A-EAE). Scopo dello studio era di osservare le modificazioni dei Potenziali Evocati stimolo correlati durante la progressione della malattia demielinizzante. Pertanto, prima dell'iniezione sensibilizzante e durante il decorso della malattia, sono stati registrati in tutti gli animali i potenziali evocati Visivi, Acustici troncoencefalici e Somatosensoriali. Un aumento di latenza dei potenziali evocati era repertabile dopo 15 giorni dall'iniezione sensibilizzante, concomitante o precedente la comparsa di sintomi clinici, quando non era ancora possibile evidenziare placche di demielinizzazione nei reperti anatomopatologici. Nel presente lavoro si discute la patofisiologia delle alterazioni dei potenziali evocati nell'EAE.
    Notes: Abstract Experimental allergic encephalomyelitis (EAE) in its chronic relapsing (CR-EAE), chronic progressive (CP-EAE) and acute (A-EAE) forms was obtained in 24 juvenile strain 13 guinea pigs. Visual, brainstem acoustic and somatosensory evoked potentials (EPs) were recorded in these animals prior to the sensitizing injection and during the course of the disease. Delays in the EPs appeared 15 days post-sensitization (dps), preceding or simultaneously with clinical alterations: electron microscopy revealed myelin stripping and vacuolation in the animals sacrificed 25 dps. Decreases in EP latency were recorded 32 dps; when electron microscopy revealed myelin layers indicating remyelination, whereas light microscopy showed only inflammatory changes. When confluent plaques were revealed by light microscopy 120 dps, the EP wave shapes were distorted or absent. The discussion reviews the literature on early myelin and conduction changes during central demyelination.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01995706
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    24-month follow-up of multiple sclerosis patients treated with cyclophosphamide (1990)
    Springer
    Neurological sciences 11 (1990), S. 605-607 
    Details
    ISSN: 1590-3478
    Keywords: Cyclophosphamide ; multiple sclerosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario 15 pazienti affetti da sclerosi multipla remittente-progressiva, sono stati sottoposti a ciclo di CTX endovena con richiami ogni sessanta giorni. Non ci sono stati pesanti effetti collaterali a breve e medio termine. A due anni di follow-up il 50% dei pazienti ha mostrato una stabilizzazione della malattia. I dati orientano per una continuazione dello studio su pazienti con giovane età e passaggio dalla forma remittente a remittente-progressiva da breve tempo.
    Notes: Abstract 15 patients with remitting-progressive multiple sclerosis received a course of intravenous cyclophosphamide followed by a booster dose every 60 days for 2 years. There were no severe short or medium term side effects. Half of the patients presented clinical stabilization and substantially unchanged Kurtzke rating at 2 year follow-up. Since the aim was stabilization only, our findings argue for continuation of the study in young patients with very short shift.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02337446
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    Paper (German National Licenses)
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