ISSN:
1432-069X
Keywords:
Pityriasis rosea
;
Langerhans cells
;
Lymphocyte subsets
;
Monoclonal antibodies
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary In 15 patients with pityriasis rosea, we studied the evolutionary changes of the immunohistological characteristics of the secondary lesions. Many CD1a+ cells were seen in the epidermis and dermis of early lesions. In the well-developed lesions, the number of CD1a+ cells greatly increased in the dermis. In the late lesions, CD1a+ cells in the dermis significantly decreased as compared with the well-developed lesions. Early lesions showed a moderate T-cell infiltrate. In the well-developed lesions, the dermal T-cell infiltrate was dense, and the CD4 CD8 ratio was 2.9. The late lesions had a moderate T-cell infiltrate, in which the CD4 CD8 ratio significantly decreased as compared with the well-developed lesions. Thus, the relative decrease in CD4+ helper inducer cells during lesion regression, concomitant with a decrease in number of CD1a+. Langerhans cells, is in accordance with a broader concept of increased suppressor mechanisms during healing.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00429978
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