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  • 1
    Electronic Resource
    Electronic Resource
    Effects of pre- and postnatal cysteamine exposure on renal function in the rat (1999)
    Springer
    Pediatric nephrology 13 (1999), S. 812-815 
    Details
    ISSN: 1432-198X
    Keywords: Key words Cystinosis ; Cysteamine ; Renal function ; Rat ; Prenatal
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The safety of cysteamine after renal transplantation and during pregnancy is an important issue, since girls with cystinosis are in better health on cysteamine therapy and thus more likely to become pregnant. In the first study, cysteamine was given to pregnant rats on days 6.5–18.5 post conception in oral doses of 0, 37.5, 75, 100, and 150 mg/kg per day. The dams were sacrificed on day 20.5, the fetal kidneys removed and prepared for histological examination. In the second study, cysteamine was given to dams on days 6.5–19.5 post conception in oral doses of 0, 37.5, 50, and 75 mg/kg per day. Dams were allowed to give birth naturally and pups were given cysteamine on days 4–21 to yield the same oral doses of cysteamine given to the dam. Renal function was evaluated on day 35. Histological examination of fetal kidneys revealed no changes even in kidneys from fetuses with growth retardation and malformations. Furthermore, there were no alterations in renal function in offspring on day 35. These findings demonstrate that cysteamine therapy does not affect renal development in the rat. Further investigations will be required to prove whether cysteamine therapy has the potential to affect renal development in the human.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004670050706
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Polymer treatment in the flowing afterglow of an oxygen microwave discharge: Active species profile concentrations and kinetics of the functionalization (1995)
    Springer
    Plasma chemistry and plasma processing 15 (1995), S. 173-198 
    Details
    ISSN: 1572-8986
    Keywords: Singlet molecular oxygen ; atomic oxygen ; flowing afterglow ; downstream reactor ; microwave discharge ; PP ; PF ; PC ; hexatriacontane ; octadecyloctadecanoate ; functionalization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Technology
    Notes: Abstract The surface treatment of different polymers and their corresponding model surfaces in the flowing afterglow of an oxygen microwave plasma is investigated. The concentration profiles of tire long-lived species issued from the plasma are measured and calculated in the downstream area The influence of atomic and singlet molecular oxygen in the behavior of different polymers is investigated. It appears that the evolution of the surface energy can be explained by an initiation of the functionalization by the oxygen atoms impinging upon the surface followed by reaction of the radicals formed with molecular oxygen. The concentration of functions at the sureface is limited due to their destruction by reaction with oxygen atoms. Furthermore, the functionalization level is higher in the /lowing afterglow than in the plasma, without any significant degradation of the polymer surface. Therefore, the treatment in the flowing afterglow is more efficient to increase suface energy in particular, for polymers which undergo high backbone chain scission.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01459695
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    Paper (German National Licenses)
    Fulltext
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