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  • 1
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Affective Disorders 6 (1984), S. 265-272 
    ISSN: 0165-0327
    Keywords: Adolescence ; DST ; GH stimulation ; Major depressive disorder ; Puberty ; REM latency
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine , Psychology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Affective Disorders 6 (1984), S. 265-272 
    ISSN: 0165-0327
    Keywords: Adolescence ; DST ; GH stimulation ; Major depressive disorder ; Puberty ; REM latency
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine , Psychology
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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  • 3
    ISSN: 1433-8580
    Keywords: Glycogen ; Glucose ; Skeletal Muscle ; Bicycle Ergometer ; Glykogen ; Glucose ; Skeletmuskel ; Fahrradergometerarbeit
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung An 18 männlichen Versuchspersonen (19–29 Jahre) wurde bei Fahrradergometerbelastung von 2 Std Dauer, die 50% der maximalen Sauerstoffaufnahme entsprach, das Verhalten von Muskelglykogen, Blutglucose, Insulin, RQ und Lactat untersucht. Nach 10 bzw. 30 min Arbeit wurden keine signifikanten Veränderungen im Glykogengehalt beobachtet. Nach 2 Std fand sich jedoch ein gesicherter Abfall um 2,10 g/100 g Trockengewicht. Im Verlauf der Arbeit sank der Anteil der Kohlenhydrate an der Gesamtverbrennung ab und der der Fette stieg an. Kontinuierliche orale Glucosegabe führte zu einem insignifikant verringerten Glykogenabbau. Die Differenz betrug nach 30 min 0,55 g%, nach 2 Std 0,26 g%. Das Verhältnis von KH- und Fettverbrennung war zugunsten der Kohlenhydrate verschoben und blieb während des Versuchs konstant. Eine Mikromethode zur Bestimmung des Glykogengehalts in menschlichen Skeletmuskelproben wird angegeben.
    Notes: Summary Glycogen content of muscle, blood glucose, insuline, FFA, RQ, and lactate were investigated in 18 male subjects (aged 19–29) during a 2 hrs work on bicycle ergometer corresponding to 50% of the Vo2 max. After a work period of 10 resp. 30 min no significant change in glycogen content was observed, while after 2 hrs a significant decrease of 2.10 g per 100 g dry weight was found. During work the utilization of carbohydrates decreased, fatty oxidation increased. Continuous oral glucose application reduced the fall of glycogen. After 30 min there was an insignificant difference of 0.55 g%, after 2 hrs 0.26 g%. The utilization of carbohydrates was increased and did not show any change during the work period. A micro-method is described for the determination of the glycogen content of specimens of human skeletal muscle.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1076
    Keywords: Methylmalonic aciduria ; Vitamin B12 ; GABA ; Cerebrospinal fluid ; Encephalomyelopathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report on two siblings, a girl of 7 years and a boy of 2 years, who presented in infancy with hypotonia, athetoid movements, myopathy and severe developmental delay. The progressive clinical course was characterized by ophthalmoplegia, pyramidal tract signs, loss of visual contanct and failure to thrive. The older sister died at the age of 7 years. The younger brother followed an almost identical clinical course. MRI of the brain revealed bilateral hypodensities and atrophy of the putamen. Neurophysiological investigations were consistent with peripheral neuropathy. Investigations for neurometabolic disorders in urine, plasma and CSF of both patients revealed a consistent increase of methylmalonic acid in urine, plasma and CSF as well as borderline low free GABA in CSF. Except for an inconstant elevation of lactate in the boy, metabolic acidosis, hypoglycaemia, episodic ketoacidosis, or hyperammonaemia, the usual concomitants of organoacidopathies, were absent in both children. Homocystinuria was excluded. Methylmalonic aciduria did not respond to antibiotic treatment, vitamin B12 therapy nor dietary protein restriction. Incorporation of [14C]propionate into protein in cultured fibroblasts was pathologically but inconsistently decreased. Both patients' cell lines showed only minimal response to hydroxocobalamin and normal methylmalonyl-CoA mutase activity. Conclusion Even though the definitive undorlying enzymatic defect in this sibship remains obscure our results suggest a new genetic disorder. This report illustrates that hitherto undescribed metabolic disorders remain to be elucidated even in long investigated areas of intermediary metabolism such as methylmalonic aciduria.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-1076
    Keywords: Key words Methylmalonic ; aciduria ; Vitamin B12 ; GABA ; Cerebrospinal fluid ; Encephalomyelopathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report on two siblings, a girl of 7 years and a boy of 2 years, who presented in infancy with hypotonia, athetoid movements, myopathy and severe developmental delay. The progressive clinical course was characterized by ophthalmoplegia, pyramidal tract signs, loss of visual contact and failure to thrive. The older sister died at the age of 7 years. The younger brother followed an almost identical clinical course. MRI of the brain revealed bilateral hypodensities and atrophy of the putamen. Neurophysiological investigations were consistent with peripheral neuropathy. Investigations for neurometabolic disorders in urine, plasma and CSF of both patients revealed a consistent increase of methylmalonic acid in urine, plasma and CSF as well as borderline low free GABA in CSF. Except for an inconstant elevation of lactate in the boy, metabolic acidosis, hypoglycaemia, episodic ketoacidosis, or hyperammonaemia, the usual concomitants of organoacidopathies, were absent in both children. Homocystinuria was excluded. Methylmalonic aciduria did not respond to antibiotic treatment, vitamin B12 therapy nor dietary protein restriction. Incorporation of [14C]propionate into protein in cultured fibroblasts was pathologically but inconsistently decreased. Both patients’ cell lines showed only minimal response to hydroxocobalamin and normal methylmalonyl-CoA mutase activity. Conclusion Even though the definitive underlying enzymatic defect in this sibship remains obscure our results suggest a new genetic disorder. This report illustrates that hitherto undescribed metabolic disorders remain to be elucidated even in long investigated areas of intermediary metabolism such as methylmalonic aciduria.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1439-6327
    Keywords: Muscle Metabolism ; Carbohydrate Metabolism ; Hexokinase Glucose ; Insulin ; Bicycle Ergometer Work ; Muskelstoffwechsel ; Kohlenhydratstoffwechsel ; Hexokinase ; Glucose ; Insulin ; Fahrrad-Ergometerarbeit
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung An 6 jungen männlichen Probanden wurde der Einfluß von oraler Kohlenhydratgabe und Fahrradergometerarbeit auf die Muskel-Hexokinaseaktivität, den Blutglucosespiegel und die Seruminsulinkonzentration untersucht. Bei kontinuierlicher Verabreichung von insgesamt 150 g Glucose stieg die Hexokinaseaktivität innerhalb von 3 Std significant an. Unter Arbeit bei 155 bis 195 Watt stieg die Hexokinaseaktivität zunächst an und fiel mit zunehmender Erschöpfung wieder auf den Ausgangswert ab. Die möglichen Regulationsmechanismen werden diskutiert.
    Notes: Abstract The influence of orally administered carbohydrates and bicycle work on muscle hexokinase activity, blood glucose, and serum insulin levels were studied in 6 young men. Continuously administered glucose of a total amount of 150 g caused a significant increase in hexokinase activity within 3 hrs. Working at a load of 155 to 195 Watt led to an initial increase of hexokinase activity. At the end of the working period hexokinase activity had fallen to resting values. The possible mechanisms of action are discussed.
    Type of Medium: Electronic Resource
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