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  • 1
    ISSN: 1432-0533
    Keywords: Amyloid precursor protein ; β-amyloid ; Quinolinic acid ; Astrocytes ; Microglia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Clinical and experimental data have indicated an up-regulation of amyloid precursor protein (APP) after various types of CNS injury. In the present study the cellular source of lesion-induced APP has been investigated an a neurotoxic CNS model. Quinolinic acid injection into the striatum results in neuronal degeneration, while glial cells survive. APP immunoreactivity was detected in glial cells starting at postoperative day 3 and persisted until day 21, the last time point studied. Double immunocytochemistry identified the majority of APP-immunoreactive cells as glial fibrillary acidic protein-immunoreactive astrocytes. There was no evidence of amyloid fibril deposition during this time. It is concluded that following excitotoxic neuronal degneration APP is mainly produced by reactive astrocytes in the lesioned area.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0533
    Keywords: Key words     Amyloid precursor protein ; β-amyloid ; Quinolinic acid ; Astrocytes ; Microglia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract      Clinical and experimental data have indicated an up-regulation of amyloid precursor protein (APP) after various types of CNS injury. In the present study the cellular source of lesion-induced APP has been investigated in a neurotoxic CNS model. Quinolinic acid injection into the striatum results in neuronal degeneration, while glial cells survive. APP immunoreactivity was detected in glial cells starting at postoperative day 3 and persisted until day 21, the last time point studied. Double immunocytochemistry identified the majority of APP-immunoreactive cells as glial fibrillary acidic protein-immunoreactive astrocytes. There was no evidence of amyloid fibril deposition during this time. It is concluded that following excitotoxic neuronal degneration APP is mainly produced by reactive astrocytes in the lesioned area.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-2013
    Keywords: Primary Muscle Spindle Endings ; Static and Dynamic Sensitivities ; Decerebrate State ; Spinalization ; Deefferentation ; Primäre Muskelspindelendigungen ; Statische und dynamische Empfindlichkeiten ; Dezerebrierungsstarre ; Spinalisierung ; Deefferentierung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 1. Primäre Spindelafferenzen, die bei anaesthesierten Katzen (Fluothane- oder Äther-Stickoxydul-Sauerstoffgemisch) rampenförmige Muskeldehnungen statisch und dynamisch gut beantworten, verlieren nach intercolliculärer Dezerebrierung sowohl an statischer als auch an dynamischer Aktivität. Sofern diese Afferenzen aus Extensoren stammen, führen Spinalisierung und Deefferentierung eine zusätzliche Aktivitätsminderung herbei. 2. Handelt es sich hingegen um primäre Spindelafferenzen, die bei anaesthesierten Katzen ansteigende Muskeldehnungen statisch schlecht oder gar nicht messen, dann nimmt deren Aktivität nach intercolliculärer Dezerebrierung zu, ist allerdings erst nach Deefferentierung maximal. 3. Aus den Ergebnissen wird geschlossen, daß die intercolliculäre Dezerebrierung fusimotorische Spindelsysteme nicht enthemmt.
    Notes: Summary 1. In cats, anesthetized either with mixtures of Fluothane and nitrous oxide or ether and nitrous oxide, primary spindle afferents lose to some extent their static and dynamic responsiveness after intercollicular decerebration, provided that they responded before decerebration quite well to ramp-like muscle extension. If this type of afferents originate from extensor muscles, an additional reduction of their activity is caused by sectioning the spinal cord at Th XII and by deefferentation. 2. In contrast, the static activity of primary endings increases after intercollicular decerebration and spinalization, if their static responsiveness to muscle extension was insufficient before decerebration. In this case, however, maximum activity is not reached until the ventral roots are cut. 3. It is concluded that the intercollicular decerebration does not enhance the activity of primary spindle afferents by release of fusimotor activity.
    Type of Medium: Electronic Resource
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