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  • Dendritic spines  (1)
  • Diencephalon  (1)
  • Golgi stain  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Morphology and distribution of Alzheimer neuritic (senile) and amyloid plaques in striatum and diencephalon (1984)
    Springer
    Acta neuropathologica 64 (1984), S. 273-281 
    Details
    ISSN: 1432-0533
    Keywords: Alzheimer plaques ; Striatum ; Diencephalon ; White matter ; Subcortical fiber tracts
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Mapping of striatal and diencephalic plaque distribution was conducted in 25 cases of dementia of the Alzheimer type. This analysis was carried out by fluorescence microscopy of paraffinembedded tissue sections treated with Thioflavine S as fluorochrome. Consistent differences in plaque morphology and density between nuclei and fiber tracts were observed. Striatal and pallidal distribution was uneven, with plaque aggregation near and within certain fiber tracts: capsules, medullary laminae, and radial fasciculi. Diencephalic plaques showed also preferred aggregation near and within fiber tracts and within the intralaminar nuclei. The different subcortical plaque morphologies observed according to the nuclear or fiber tract location of the amyloid plaque, indicates that the peripheral (“halo”) portion of the plaque is determined by the neuropil response to the primary event: the amyloid deposit. No correlation was observed between the distribution of plaques and any particular neurotransmitter system. In that respect, plaques were present within the nucleus basalis. Neurofibrillary tangle distribution was also seen to be dissociated from plaque distribution.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00690393
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Adult fragile X syndrome (1985)
    Springer
    Acta neuropathologica 67 (1985), S. 289-295 
    Details
    ISSN: 1432-0533
    Keywords: Fragile X ; Synapses ; Dendritic spines ; Macro-orchidism ; Golgi stain
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Fragile X syndrome [fra (X)] is currently accepted as the second most frequent chromosomal disorder associated with developmental disability. Although next to Down syndrome in frequency, no postmortem studies of confirmed adult cases had been reported. The autopsy examination of a 62-year-old, moderately retarded man with the fra (X) syndrome confirmed the preferential involvement of cerebral and testicular structures in this disorder.Dendritic spine abnormalities of the type observed in trisomic chromosomal disorders were associated with synaptic immaturity. Severe testicular hypogonadism accompanied bilateralmacro-orchidism, normal penis, and unilateral hydrocele. Valvular, articular, and testicular interstitial compartments showed normal histochemical staining characteristics for glycoproteins and lipids.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687814
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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