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  • 1
    Electronic Resource
    Electronic Resource
    Cancer in phenoxy herbicide manufacturing workers in Denmark, 1947–87—an update (1993)
    Springer
    Cancer causes & control 4 (1993), S. 261-272 
    Details
    ISSN: 1573-7225
    Keywords: Cancer incidence ; Denmark ; non-Hodgkin's lymphoma ; phenoxy herbicide ; soft tissue sarcoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: This report is an update of a cohort study from the two Danish phenoxy herbicide manufacturing plants. The study originally covered the period 1947–82. Data now have been added for the period 1983–87. In 1943–87, the 940 phenoxy herbicide manufacturing and packaging workers experienced the same overall cancer incidence as the Danish population (observed [Obs]=66; expected [Exp]=64.27; standardized incidence ratio [SIR]=1.0; 95 percent confidence interval [CI]=0.8–1.3). The same was true for the 1,179 workers employed in manual service functions. The data for 1947–82 included five cases of soft tissue sarcoma (STS). One of these patients had his diagnosis changed when he died in 1985. One new STS case was diagnosed during the period 1983–87. This updated study thus includes a total of five STS cases. Four of the STS cases were observed among persons potentially exposed to phenoxy herbicide (Exp=1.76; SIR=2.3; CI=0.6–5.8). Three of the cases occurred among men employed for at least one year in one factory. In this subgroup, an SIR of 6.4 (CI=1.3–18.7) was observed when a 10-year latency period was taken into account. Based on small numbers, this Danish study thus continues to add to the evidence for a possible association between phenoxy herbicide exposure and risk of STS. Persons potentially exposed to phenoxy herbicide had an incidence of non-Hodgkin's lymphoma close to that of the Danish population (Obs=4; Exp=3.08; SIR=1.3; CI=0.4–3.3).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00051321
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  • 2
    Electronic Resource
    Electronic Resource
    Case-control study of risk factors for cervical neoplasia in Denmark. II. Role of sexual activity, reproductive factors, and venereal infections (1992)
    Springer
    Cancer causes & control 3 (1992), S. 339-348 
    Details
    ISSN: 1573-7225
    Keywords: Cervical cancer ; Denmark ; reproduction ; sexual activity ; venereal diseases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Sexual, reproductive and venereal risk factors for cervical neoplasia were investigated in a population-based case-control study of 586 women with histologically verified, cervical squamous-cell carcinoma in situ, and 59 women with invasive squamous-cell cervical cancer, diagnosed from 1985 to 1986 in Copenhagen. Cases were identified from the computerized Danish Cancer Registry. An age-stratified control group (n=614) was drawn at random from the female population in the study area by means of the Danish Central Population Register. A structured questionnaire was mailed to cases as well as controls. Increasing number of sexual partners exerted a significant effect on the risk both for carcinoma in situ, and invasive cancer, independently of age at first intercourse and other potential confounders. Conversely, the association with early age at first intercourse became statistically insignificant after allowance for other risk factors, although an increasing risk was still observed with decreasing age at sexual debut. Early age at first episode with genital warts was a significant risk factor for carcinoma in situ, perhaps indicating a possible increased susceptibility of the cervix epithelium during adolescence. A history of genital warts was a good predictor of risk for carcinoma in situ, whereas a history of previous gonorrhea was associated with an increased risk for invasive carcinoma. Women with multiple births had a significantly increased adjusted risk, especially for carcinoma in situ, although some association was also observed with invasive cervical cancer. The study supports the hypothesis of cervical neoplasia being a sexually transmitted disease, and that carcinoma in situ and invasive cervical carcinoma, to a high degree, have similar patterns of risk factors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00146887
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    Paper (German National Licenses)
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