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  • Dependence on TT4- and TBG-serum concentrations  (1)
  • Submaximal physical exercise  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 62 (1984), S. 640-650 
    ISSN: 1432-1440
    Keywords: Thyroid hormone therapy ; RIA-FT4 (AMERLEX) ; Dependence on TT4- and TBG-serum concentrations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In patients undergoing long-term thyroid hormone therapy with constant doses the results of FT4 concentrations measured by radioimmunoassay (FT4-AMERLEX) were compared with calculated FT4 values and related to total thyroxine, serum TBG levels, respectively T4/TBG, to control the validity of radioimmunologic FT4 measurements for clinical routine diagnostic purposes. Based on mathematical analyses on the interdependence of these values the following principles were confirmed: free thyroxine measurements are dependent on total thyroxine with a power of x to the exponent and on T4/TBG-ratio with an exponential function. The percentage of free thyroxine (FT4/TT4 ratio) is inversely and exponentially related to serum TBG concentrations. Indeed, the RIA-FT4 results are largely independent of the concentration of binding globulin within certain limits. In thyroid patients without extrathyroid disorders no grossly false hypo- or hyperthyroid FT4 values are to be expected by deviating thyroxine globulin concentrations.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of applied physiology 48 (1982), S. 31-39 
    ISSN: 1439-6327
    Keywords: Maximal physical exercise ; Submaximal physical exercise ; Thyreoidea stimulating hormone ; Thyroid hormones
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The response of various thyroid hormone parameters to maximal physical exercise (MPE) was investigated in 14 medium and long distance runners and 13 divers. The effect of submaximal long time physical exercise (SMPE) was examined in seven divers. The TSH-level decreases significantly during MPE and slightly rises again after the end of the exercise. In SMPE, however, TSH continuously rises until 15 min after the end of the exercise. The T3 level rises significantly in MPE and falls below the initial value 15 min after the exercise finishes, during SMPE it remains practically unchanged and slightly decreases after the finish. In MPE, the rT3 level does not change and slightly decreases after termination, while the fT4 level continuously decreases from the beginning till 15 min after the exercise period. The latter two parameters do not show any change in SMPE. As possible reasons for the changes of TSH levels a decrease (MPE) or an increase (SMPE) of pituitary secretion might play a role. Furthermore, in MPE the rise in T3 level might be related to hemoconcentration, and the decrease in fT4 level to an elevated cellular utilization.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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