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  • 1
    Electronic Resource
    Electronic Resource
    Selection and characterisation of flavanone 3-hydroxylase mutants ofDahlia, Streptocarpus, Verbena andZinnia (1984)
    Springer
    Planta 161 (1984), S. 261-265 
    Details
    ISSN: 1432-2048
    Keywords: Acyanic mutants ; Anthocyanin biosynthesis ; Dahlia ; Flavanone 3-hydroxylase ; Mutant (white-flowering) ; Streptocarpus ; Verbena ; Zinnia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Precursor experiments and chromatographic studies indicate that the hydroxylation of flavanones in the 3-position to dihydroflavonols is blocked in special white-flowering mutants ofDahlia, Streptocarpus, Verbena andZinnia. The result of our investigations was confirmed in as much as the activity of the enzyme flavanone 3-hydroxylase, which catalyses the conversion of flavanones to dihydroflavonols, could readily be detected in flower extracts of cyanic strains of the four plant species. It was found to be, however, completely absent in flower extracts of the corresponding acyanic mutants. Thus, the interruption of the anthocyanin pathway in these mutants is clearly caused by a lack of this enzyme activity. Similar to the enzymes from other sources, the 3-hydroxylases ofDahlia, Streptocarpus, Verbena andZinnia are soluble enzymes; they belong to the 2-oxoglutarate-dependent dioxygenases and the reaction is inhibited by ethylenediaminetetraacetic acid, KCN and diethyldithiocarbamate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00982923
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  • 2
    Electronic Resource
    Electronic Resource
    The loudness dependency of the auditory evoked N1/P2-component as a predictor of the acute SSRI response in depression (2000)
    Springer
    Psychopharmacology 148 (2000), S. 404-411 
    Details
    ISSN: 1432-2072
    Keywords: Key words Auditory evoked potentials ; Serotonin ; Depression ; Response prediction ; Augmenting/reducing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Rationale: A serotonergic dysfunction is supposed to play a pathogenetic role in depression, but there is a considerable number of non-responders in the acute treatment of depression with serotonergic agents like SSRI. Thus, an indicator of central serotonergic activity could lead to a more specific pharmacological treatment of depression. In animal and human data there is a growing amount of evidence that a strong loudness dependency of late auditory evoked potentials (LDAEP) is an indicator of low serotonergic activity and vice versa. Objective: In 29 depressive inpatients (DSM-III-R diagnosis 296.x in 28 patients, 300.4 in one patient), the hypothesis was tested that a strong LDAEP prior to treatment can predict a better clinical outcome under SSRI treatment over 4 weeks. Results: Patients with a strong pre-treatment LDAEP had a significantly greater decrease of depressive symptoms (Hamilton Scale for Depression) after 4 weeks than patients with a flat LDAEP. Significantly more responders fell into the group with a high LDAEP. Contrary to what might be expected, a second recording in a subsample of 19 patients after 4 weeks of treatment failed to show changes in the LDAEP. Conclusion: Our finding confirms the hypothesis that a strong LDAEP, indicating a low serotonergic activity, is related to a favorable response to acute SSRI treatment in depression. The LDAEP is a promising tool for the prediction of response to serotonin agonists in depression and it seems to be of clinical importance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002130050070
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Genetic and biochemical studies on flavonoid 3′-hydroxylation in flowers of Petunia hybrida (1985)
    Springer
    Theoretical and applied genetics 70 (1985), S. 300-305 
    Details
    ISSN: 1432-2242
    Keywords: Anthocyanin biosynthesis ; Flavonoid 3′-hydroxylase ; Genetic control ; Petunia hybrida
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary In flower extracts of defined genotypes of Petunia hybrida, an enzyme activity was demonstrated which catalyses the hydroxylation of naringenin and dihydrokaempferol in the 3′-position. Similar to the flavonoid 3′-hydroxylases of other plants, the enzyme activity was found to be localized in the microsomal fraction and the reaction required NADPH as cofactor. A strict correlation was found between 3′-hydroxylase activity and the gene Ht1, which is known to be involved in the hydroxylation of flavonoids in the 3′-position in Petunia. Thus, the introduction of the 3′-hydroxyl group is clearly achieved by hydroxylation of C15-intermediates, and the concomitant occurrence of the 3′,4′-hydroxylated flavonoids quercetin and cyanidin (paeonidin) in the presence of the functional allele Ht1 is due to the action of one specific hydroxylase catalysing the hydroxylation of common precursors for both flavonols and anthocyanins.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00304915
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    Paper (German National Licenses)
    Fulltext
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