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  • Rat  (7)
  • Rabbit  (3)
  • Development  (2)
  • Rat (Wistar)  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Early bronchopulmonary lesions in rat lung after normobaric 100% oxygen exposure and their evolution (1989)
    Springer
    Virchows Archiv 414 (1989), S. 135-145 
    Details
    ISSN: 1432-2307
    Keywords: Hyperoxia ; Lung broncho-vascular reaction ; Electron microscopy ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In order to clarify the early phenomena involved in the lung reaction to hyperoxia, twenty adult male rats were exposed to 100% oxygen at 1 ATA. Morphological pulmonary lesions were detectable after only 24 h hyperoxia, and included vasoconstriction and perivascular oedema, bronchiolar constriction, and pericyte reaction. The lesions were irregularly scattered within the lung parenchyma and occurred preferentially in areas centred on bronchiolo-vascular stems. Even at the latest stages, pulmonary heterogeneity was obvious, from the coexistence of areas damaged at different times. Neuro-epithelial-bodies were found under the bronchiolar epithelium; the morphological aspect of the neuro-endocrine cells observed was consistent with hyperoxia-induced modulation of their secretory activity. Taken together, our findings show the speed of development of hyperoxia-induced pulmonary changes and raise some pathogenic considerations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00718593
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  • 2
    Electronic Resource
    Electronic Resource
    Ontogenesis of the rabbit pituitary intermediate lobe (1993)
    Springer
    Anatomy and embryology 187 (1993), S. 87-97 
    Details
    ISSN: 1432-0568
    Keywords: Pituitary intermediate lobe ; Rabbit ; Ontogenesis ; Immunocytochemistry ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The development of the intermediate lobe of the rabbit pituitary was investigated by light and electron microscopy and by using immunocytological techniques. The first immunoreactive melanotrophic cells were detected at the fetal day 17 in the dorsal zone of Rathke's pouch epithelium facing the neural lobe; this coincided ultrastructurally with the appearance in this area of a few cells exhibiting secretory vesicles and granular condensations in the Golgi saccules. The differentiation of the gland probably required an infundibular inductive effect. Secretory cells increased in number following a dorsoventral gradient during the next fetal and neonatal stages until postnatal day 20, the stage at which the intermediate lobe exhibited its definitive organization. The gland innervation occurred during the first days after birth. The advent of these oxytocin- and neurophysin-immunoreactive fibres coincided with an obvious stimulation of the synthetic activity of the melanotrophic cells. The possible neurotrophic effect of these cells on their innervating system remains to be established.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00208199
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  • 3
    Electronic Resource
    Electronic Resource
    Sur l'existence de cellules de type ≪corticotrope≫ dans la pars intermedia de l'hypophyse du rat (1971)
    Springer
    Cell & tissue research 115 (1971), S. 60-68 
    Details
    ISSN: 1432-0878
    Keywords: Adenohypophysis ; Pars intermedia ; Corticotrophic cells ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Résumé Nos observations démontrent l'existence de deux types de cellules glandulaires dans la pars intermedia de l'hypophyse du rat: des cellules propres, à M.S.H., dont les grains de sécrétion sont détruits par la fixation osmiée et relativement bien conservés par la fixation au glutaraldéhyde; des cellules à petits grains denses, osmio-résistants, qui s'apparentent morphologiquement aux éléments corticotropes de l'antéhypophyse. L'existence bien connue d'A.C.T.H. ou, plus précisément, d'un facteur ≪A.C.T.H.-like≫ dans le lobe neuro-intermédiaire nous fait considérer comme très vraisemblable la nature corticotrope de ce deuxième type cellulaire de la pars intermedia.
    Notes: Summary Two types of glandular cells have been shown to occur in the intermediate lobe of the rat hypophysis: 1) M.S.H. producing cells whose secretory granules are destroyed by osmium fixation and relatively well preserved by glutaraldehyde fixation, 2) cells with small dense osmium resistant granules being morphologically similar to the corticotrophic cells of the anterior lobe. The well known occurrence of A.C.T.H. or, more precisely, of an “A.C.T.H.-like” factor in the neuro-intermediate lobe makes the corticotrophic nature of this second cell type very likely.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00330214
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  • 4
    Electronic Resource
    Electronic Resource
    Origine embryonnaire et différenciation sécrétoire des cellules à calcitonine (cellules C) dans la thyroïde foetale du rat (1970)
    Springer
    Cell & tissue research 106 (1970), S. 251-268 
    Details
    ISSN: 1432-0878
    Keywords: C cells ; Thyroid ; Rat ; Ultimobranchial origin ; Differentiation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Résumé Nos observations confirment l'origine ultimobranchiale des cellules C de la thyroïde du rat. L'évolution des corps ultimobranchiaux (C.U.B.) a été étudiée à partir du 16ème jour de gestation, stade où ils fusionnent avec l'ébauche thyroïdienne. Dès le 17ème jour, les premières cellules C se différencient dans le C.U.B. inclus dans la thyroïde. Au 18ème jour, elles sont plus nombreuses et commencent à se disperser dans les cordons thyroïdiens. La migration des cellules C est particulièrement importante au 19ème jour. A partir du 20ème jour, les signes d'activité sécrétoire s'intensifient très nettement. A la fin de la vie foetale, les cellules C sont comparables aux cellules C adultes. La differenciation des cellules parathyroïdiennes précède nettement celle des cellules C.
    Notes: Summary Our observations confirm the ultimobranchial origin of the C cells of the rat thyroid. We studied the development of the ultimobranchial body from the 16th day of pregnancy, when there is fusion with the thyroidian anlage, onwards. As early as the 17th day, the first C cells differentiate in the ultimobranchial body which is included into the thyroid. On the 18th day, they are more numerous and start to scatter throughout the thyroidian cords. The migration of the C cells is especially obvious on the 19th day. From the 20th day onwards, there is marked increase in secretory activity. At the end of the foetal life, the C cells resemble those of the adult. The differentiation of the parathyroid cells significantly precedes that of the C cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00335742
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  • 5
    Electronic Resource
    Electronic Resource
    A light and electron microscopic study of the pre- and postnatal development and secretory differentiation of the pars tuberalis of the rat hypophysis (1973)
    Springer
    Cell & tissue research 142 (1973), S. 347-365 
    Details
    ISSN: 1432-0878
    Keywords: Pars tuberalis ; Rat ; Development ; Secretion ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The development of the pars tuberalis was studied in the rat fetus from 13 days of gestation to 6 weeks after birth. After the closure of Rathke's pouch, the pars tuberalis anlage is clearly distinguishable from the anlagen of the partes intermedia and distalis. It comprises the entire basal portion of the adenohypophysial anlage; the limit between the anlagen of the pars tuberalis and the pars distalis is defined by Atwell's recess, i.e. the pathway taken by the hypophysial vessels coming from the vascular plexus of the median eminence. At 14 days the pars tuberalis cells are characterized by the presence of glycogen which persists in the adult. Their secretory differentiation (elaboration of granules with a diameter of 100–120 nm) is obvious at 15 days of gestation. It therefore, clearly precedes that of the other hypophysial cell types. Its functional differentiation takes place well before its adhesion to the primary vascular plexus of the portal system. Cystic formations appear just before birth in the pars tuberalis, much later than those of the pars distalis. These observations on the development of the pars tuberalis, together with previous observations on the adult PT in various species, showing that the specific glandular cells of the pars tuberalis are cytologically different from all known adenohypophysial cell types, seem to indicate a specific endocrine function of this lobe.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00307357
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  • 6
    Electronic Resource
    Electronic Resource
    Immunocytochemical evidence for intragranular processing of pro-opiomelanocortin in the melanotropic cells of the rabbit (1985)
    Springer
    Cell & tissue research 242 (1985), S. 365-370 
    Details
    ISSN: 1432-0878
    Keywords: Melanotrophs ; Immunogold technique ; Secretory vesicles ; γ3-MSH ; α-MSH ; Endorphins ; Rabbit
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The immunogold technique, employing antisera with clear-cut specificities, was used to localise different processing stages of pro-opiomelanocortin (POMC) in rabbit melanotropic cells. While the antiserum against γ 3-MSH labelled all the secretory granules including intrasaccular condensations in the Golgi apparatus, antisera against α-MSH only labelled extra-Golgi secretory vesicles (SV). All extra-Golgi SV were likewise labelled with the three antisera against α-MSH used, despite their different specificities for the desacetylated, N-acetylated or C-amidated forms of the peptide. The antibody against β-endorphin also labelled the extra-Golgi SV, while only some SV were labelled with the antibody against γ-endorphin. These results correlate with biochemical data in favour of mainly — if not exclusively — intragranular processing of POMC. Except for γ3-MSH, the cleavage of which could coincide with Golgi packaging of secretory material, other post-translational modifications of the precursor seem to occur when SV are discharged outside the Golgi area. The cleavage of γ-endorphin appears to be a later step in POMC processing, occurring in some mature SV.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00214549
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  • 7
    Electronic Resource
    Electronic Resource
    Differentiation of the melanotrophic cells of rat pituitary primordium in organotypic culture in defined medium (1992)
    Springer
    Cell & tissue research 267 (1992), S. 169-183 
    Details
    ISSN: 1432-0878
    Keywords: Fetal intermediate lobe ; Tissue culture ; Immunocytochemistry ; In situ hybridization ; Dopamine ; Rat (Wistar)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Organotypic cultures, in defined medium, of pituitary primordia obtained from 15-day-old rat fetuses were performed in order to study the in vitro differentiation of melanotrophic cells. The morphological and ultrastructural features of the transplants resembled those of the gland developing in vivo. In situ hybridization on semi-thin sections, using a 35S-labelled oligonucleotide probe, revealed pro-opiomelanocortin-mRNA-containing cells on the first day of culture in the anterior lobe and after 2–3 days in the intermediate lobe. Immunoperoxidase labelling of adjacent sections showed that the same cells reacted with antibodies against α-melanocyte-stimulating hormone (αMSH), γ3 and adrenocorticotropic hormone in both lobes. The pro-opiomelanocortin-mRNA-containing cells formed progressively conspicuous areas in the intermediate lobe, which was almost uniformly labelled after 6 days. In the anterior lobe, these cells remained scattered in small cell groups, and colloidal gold immunolabelling showed the progressive disappearance of αMSH labelling from the secretory vesicles in cells exhibiting morphological features of adult corticotrophic cells. Both the αMSH content of the explants and αMSH release into the culture medium increased with time. Treatment with the dopamine agonist bromocriptine induced a strong dose-dependent decrease in αMSH secretion, which was significant after 3 days in culture, indicating that dopamine D2 receptors are able to regulate hormonal release of melanotrophic cells at early stages. This system constitutes a suitable model for further studies of factors controlling cell differentiation and cellular interactions involved in histogenesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00318702
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  • 8
    Electronic Resource
    Electronic Resource
    Expression of the α-subunit of glycoprotein hormones in the pars tuberalis-specific glandular cells in rat, mouse and guinea-pig (1994)
    Springer
    Cell & tissue research 278 (1994), S. 617-624 
    Details
    ISSN: 1432-0878
    Keywords: Key words: Pituitary ; Pars tuberalis ; α-Subunit ; Immunocytochemistry ; In situ hybridization ; Rat ; Mouse ; Guinea-pig
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. The nature of the hormone(s) secreted by the pars tuberalis (PT) is still unknown. This pituitary lobe is mainly formed by specific glandular cells that differ in their ultrastructural features from the other adenohypophysial cell types. Data from the literature indicate the presence of thyroid-stimulating hormone immunoreactivity in the PT-specific cells of the rat and the Djungarian hamster but not of other species, including the mouse and guinea-pig. The PT also encloses variable numbers of pars distalis cells, essentially gonadotrophs that are mainly dispersed in its caudal area. We studied the expression of the glycoprotein hormone α-subunit in the PT of the rat, mouse and guinea-pig by in situ hybridization and immunocytochemistry. In situ hybridization, using an oligonucleotide probe complementary to rat cDNA sequence 196–237 revealed the expression of the α-subunit gene throughout the PT of the rat and the mouse; in the guinea-pig, the probe labelled no pituitary cells. Light- and electron-microscopic immunocytochemistry demonstrated α-subunit immunoreactivity in the secretory granules of the PT-specific cells in the three species examined. These cells did not react with a specific antibody against the β-subunit of luteinizing hormone, an antibody that labelled scattered gonadotrophs. The present data suggest that hormone(s) produced by the PT-specific glandular cells are, at least partly, related to glycoprotein hormones.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004410050253
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  • 9
    Electronic Resource
    Electronic Resource
    Expression of the α-subunit of glycoprotein hormones in the pars tuberalis-specific glandular cells in rat, mouse and guinea-pig (1994)
    Springer
    Cell & tissue research 278 (1994), S. 617-624 
    Details
    ISSN: 1432-0878
    Keywords: Pituitary ; Pars tuberalis ; α-Subunit ; Immunocytochemistry ; In situ hybridization ; Rat ; Mouse ; Guinea-pig
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The nature of the hormone(s) secreted by the pars tuberalis (PT) is still unknown. This pituitary lobe is mainly formed by specific glandular cells that differ in their ultrastructural features from the other adenohypophysial cell types. Data from the literature indicate the presence of thyroid-stimulating hormone immunoreactivity in the PT-specific cells of the rat and the Djungarian hamster but not of other species, including the mouse and guinea-pig. The PT also encloses variable numbers of pars distalis cells, essentially gonadotrophs that are mainly dispersed in its caudal area. We studied the expression of the glycoprotein hormone α-subunit in the PT of the rat, mouse and guinea-pig by in situ hybridization and immunocytochemistry. In situ hybridization, using an oligonucleotide probe complementary to rat cDNA sequence 196–237 revealed the expression of the α-subunit gene throughout the PT of the rat and the mouse; in the guinea-pig, the probe labelled no pituitary cells. Light-and electron-microscopic immunocytochemistry demonstrated α-subunit immunoreactivity in the secretory granules of the PT-specific cells in the three species examined. These cells did not react with a specific antibody against the β-subunit of luteinizing hormone, an antibody that labelled scattered gonadotrops. The present data suggest that hormone(s) produced by the PT-specific glandular cells are, at least partly, related to glycoprotein hormones.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00331382
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  • 10
    Electronic Resource
    Electronic Resource
    Immunocytochemical and ultrastructural studies on allografts of the pituitary neurointermediate lobe in the third cerebral ventricle of the rat (1989)
    Springer
    Cell & tissue research 255 (1989), S. 393-404 
    Details
    ISSN: 1432-0878
    Keywords: Pituitary gland ; Neural lobe ; Intermediate lobe ; Intraventricular graft ; Immunocytochemistry ; Electron microscopy ; Rat (Wistar)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Neurointermediate lobes from adult or 10-dayold rats were implanted by a stereotaxic procedure into the third ventricle of adult male rats, in an area close to the paraventricular nucleus. They were examined, using immunocytochemical and ultrastructural techniques, at times ranging from 1 week to 8 months. All grafts were recovered in a healthy condition although some rejection of the tissue was detected at the 1and 2-week stages. In the neural lobe, clusters of pituicytes were scattered among the loose network of capillaries, most of which had a fenestrated endothelium. The intermediate lobe remained organized in compact avascular lobules. Axons similar to those projecting into the neurointermediate lobe in situ, but also axons of other types (e.g., somatostatinergic, enkephalinergic) penetrated the grafts. Synapses with melanotrophic cells in the intermediate lobe and neurohaemal contacts in the neural lobe were frequent from 2 1/2 months after transplantation. Immunocytochemical and ultrastructural characteristics indicated intense secretory stimulation of the melanotrophic cells in the early stages. All cells enclosed in a same glandular lobule reacted in a similar manner. In later stages, when re-innervation occurred, the cells recovered their initial characteristics. The overall effect of the re-innervation of the intermediate lobe grafted in this location is inhibitory, as in the lobe in situ.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00224123
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