ISSN:
1432-2072
Keywords:
Phentermine
;
Appetite
;
Food Intake
;
Obesity
;
Weight Reduction
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The anorectic effects of phentermine resinate (Duromine) in doses of 15 mg and 30 mg were compared to placebo under double-blind, controlled conditions in six moderately overweight but otherwise healthy women aged 24 to 48. The relative changes in hunger produced by each of the three preparations over a period of 10 h were determined by using a visual analogue hunger scale. In addition the effect of each on calorie intake 5 h and 10 h after administration was measured. Both 15 mg and 30 mg phentermine had a significant effect on calorie intake, the dosage of 15 mg reducing calorie intake by 25%, and 30 mg by 33% over the 10 h observation period. There were corresponding changes in hunger rating observed, with a correlation of +0.68 between hunger rating and calorie intake being found. On the basis of these results it is concluded that phentermine, in doses of 15 mg and 30 mg, does have a direct appetite suppressant action.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00421970
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