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  • Di Guglielmo-Syndrom  (1)
  • Glycogen  (1)
  • In vitro culture  (1)
  • 1
    ISSN: 1432-0584
    Keywords: Chronic myeloid leukemia ; Megakaryoblastic crisis ; Cytomechistry. Cytogenetics ; Cytophotometry ; Electron microscopy ; In vitro culture
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Atypical megakaryoblasts (MKB) or megakaryocytes (MK) are occasionally present in the peripheral blood during the terminal development of chronic myeloid leukemia (CML). We report on a 49-year-old female suffering from Ph1 chromosome-positive CML with typical megakaryoblastic transformation in the peripheral blood and in the bone marrow. The small “blasts” were at the most only slightly larger and were occasionally even smaller than lymphocytes but showed megakaryoblastic or atypical megakaryocytic differentiation. The cytoplasmic cytochemical pattern of the atypical megakaryocytic cells was identical to that of large atypical thrombocytes. Platelet peroxidase was detected upon electron-microscopic (EM) examination. Immunologic characterization disclosed the presence of MK-specific antigens. When cultured in vitro on agar, the blasts transformed spontaneously into large mature MK, exhibiting characteristic cytochemical and immunological patterns. Cytogenetic examination of peripheral blood showed severe abnormalities. The patient did not respond to therapy and died 3 months after manifestation of the blast crisis.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1440
    Keywords: Glycogen ; leukocytes ; amyloglucosidase ; Glykogen ; Leukocyten ; Amyloglukosidase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung An peripheren Blutausstrichen sowie an Kontrollschnitten von Leber, Muskulatur und Schilddrüse wurde die glykogenolytische Wirkung von Amyloglukosidase geprüft. Die Spezifität dieses Enzyms beweist, daß die in den neutrophilen Granulocyten, Thrombocyten und Lymphocyten nachgewiesenen PAS-positiven Substanzen Glykogen darstellen. Die Fixierung in Formalindampf erwies sich für den anschließenden enzymatischen Glykogenabbau als ungeeignet, da nach der Fixierung in Formalindampf im Gegensatz zur Fixierung mit Äthanol, Methanol und Aceton nur ein unvollständiger Glykogenabbau zu erzielen war.
    Notes: Summary Glycogen hydrolytic activity of amyloglucosidase was studied in blood smcars and sections of liver, muscle and thyroid gland. The specificity of amyloglucosidase proved the PAS-positive substances in neutrophil granulocytes, platelets and lymphocytes to be glycogen. Fixation of the material with formalin was unsuitable as the glycogenolytic activity of amyloglucosidase was reduced after this fixation. This was possibly due to inadequate penetration of the enzyme into the cell after formalin fixation.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 50 (1972), S. 423-433 
    ISSN: 1432-1440
    Keywords: Acute leukaemia ; cytochemistry ; electron microscopy ; lymphoblast ; myeloblast ; promyelocyte ; monocyto ; Di Guglielmo Syndrome ; Unreifzellige Leukämie ; Cytochemie ; Elektronenmikroscopie ; Lymphoblast ; Myeloblast ; Promyelocyt ; Monocyt ; Di Guglielmo-Syndrom
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die leukämischen Zellen von 33 Patienten mit verschiedenen Formen unreifzelliger Leukosen wurden licht- und elektronenmikroskopisch cytochemisch untersucht. Hierdurch wurde die Klassifizierung in folgende fünf Formen ermöglicht: Lymphoblasten-Leukämie (9 Patienten); Myeloblasten-Leukämie (11 Patienten); (Pro-)Myelocyten-Leukäme (3 Patienten); Monocyten-Leukämie (8 Patienten); Di Guglielmo-Syndrom (2 Patienten). Die cytochemischen Befunde im licht- und elektronenmikroskopischen Bereich bei den einzelnen Leukämieformen wurden beschrieben und erörtert im Hinblick auf Diagnose und Klassifizierung der Leukosen und auf Abstammung und Funktion der Zellen und ihrer Organellen.
    Notes: Summary The leukaemic cells of 33 patients suffering from different forms of acute leukaemia were examined by means of light and electron microscopic cytochemistry. These methods made possible the classification into the following 5 forms of acute leukaemia: lymphoblastic leukaemia (9 patients); myeloblastic leukaemia (11 patients); (pro-) myelocytic leukaemia (3 patients); monocytic leukaemia (8 patients); Di Guglielmo-syndrome (2 patients). Light-and electron microscopic cytochemical findings concerning the different forms of leukaemia are described and discussed especially with regard to diagnosis and classification of leukaemia and to both origin and function of the leukaemic cells and of their organelles.
    Type of Medium: Electronic Resource
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