ISSN:
1432-2072
Keywords:
Diazepam
;
CER paradigm
;
Rats
;
Discriminative stimulus complex (DSC)
;
Anxiolytic effects
;
Anxiogenic effects
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Two groups of rats were trained in a CER paradigm. The conditioned stimulus was a sound, the unconditioned stimulus was an electric shock. Group 1 received conventional CER training before the effects of different doses of diazepam were studied. For Group 2 the shock was always and exclusively given contingent on pretreatment with diazepam. After prolonged training the compound thus became a discriminative stimulus complex (DSC) and produced response suppression during the CS. Group 2 was also challenged with various doses of diazepam. The results showed that diazepam acquired diametrically different properties in the two groups. Group 1 exhibited disinhibitory effects and Group 2 suppressive effects, which may reflect anxiolytic and anxiogenic properties, respectively.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00432170
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