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Inhibin/activin subunits alpha, beta-A and beta-B are differentially expressed in normal human endometrium throughout the menstrual cycle (2000)

Mylonas, Ioannis ; Jeschke, Udo ; Wiest, Irmgard ; [et al.]

Springer

Histochemistry and cell biology 122 (2000), S. 461-471

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ISSN: 1432-119X

Keywords: Endometrium ; Normal ; Immunohistochemistry ; Immunofluorescence ; Inhibin/activin subunits ; Inhibin-alpha ; Inhibin-beta A ; Inhibin-beta B

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: AbstractInhibins are dimeric glycoproteins composed of an alpha (α) subunit and one of two possible beta (β-) subunits (βA or βB). The aims of this study were to assess the frequency and tissue distribution patterns of the inhibin subunits in normal human endometrium. Samples from human endometrium from proliferative phase (PP; n=32), early secretory phase (ES; n=10) and late secretory phase (LS; n=12) were obtained. Immunohistochemistry, immunofluorescence and a statistical analysis were performed. All three inhibin subunits were expressed by normal endometrium by immunohistochemistry and immunofluorescence. Inhibin-α was primarily detected in glandular epithelial cells, while inhibin-β subunits were additionally localised in stromal tissue. Inhibin-α staining reaction increased significantly between PP and ES (P〈0.05), PP and LS (P〈0.01), and ES and LS (P〈0.02). Inhibin-βA and -βB were significant higher in LS than PP (P〈0.05) and LS than ES (P〈0.05). All three inhibin subunits were expressed by human endometrium varying across the menstrual cycle. This suggests substantial functions in human implantation of inhibin-α subunit, while stromal expression of the β subunits could be important in the paracrine signalling for adequate endometrial maturation. The distinct expression in human endometrial tissue suggests a synthesis of inhibins into the lumen and a predominant secretion of activins into the stroma.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/s00418-004-0709-6

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D-Galacturonsäurederivate, VI. D-Galacturonsäurederivate mit flüssigkristallinen Eigenschaften (1992)

Vogel, Christian ; Jeschke, Udo ; Vill, Volkmar ; [et al.]

Weinheim : Wiley-Blackwell

Liebigs Annalen 1992 (1992), S. 1171-1177

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ISSN: 0170-2041

Keywords: Carbohydrates ; Amphiphilic d-galacturonic acid derivatives ; Liquid crystals ; Discotics ; Calculations, MM2 ; Chemistry ; Organic Chemistry

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: D-Galacturonic Acid Derivatives, VI. - D-Galacturonic Acid Derivatives with Liquid Crystalline PropertiesEsters, thioesters, and amides of D-galacturonic acid have been synthesized from alcohols, thioalcohols, and amines having long alkyl chains. Key intermediate of the reaction with the different nucleophiles was the 1,2;3,4-di-O-isopropylidene-α-D-galactopyranuronosyl chloride (3). Deisopropylidenation of the protected esters, thioesters, and amides was achieved by trifluoroacetic acid. The investigation of the liquid crystalline properties was carried out with a polarizing microscop, DSC measurements, and X-ray diffraction. Molecules with three long alkyl chains can be obtained by reaction of amides 5h and 5i with thioalcohols. MM2 calculations voted a Y-shaped structure of the mercaptals 8a and 8b which do exhibit thermotropically a columnar hexagonal mesophase (Dhd) as we have proved by X-ray diffraction.

Additional Material: 1 Ill.