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The effects of deprenyl on methamphetamine-induced dopamine depletions (1992)

Johnson, S. K. ; Medina, D. ; Wagner, G. C.

Springer

Journal of neural transmission 89 (1992), S. 123-127

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ISSN: 1435-1463

Keywords: Dopamine ; deprenyl ; methamphetamine ; Parkinson's disease

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary The effects of deprenyl on methamphetamine-induced dopamine depletions were studied in mice. Four SC injections of 12.5 mg/kg of methamphetamine at two-hour intervals caused substantial (72–82%) and longlasting depletions of striatal dopamine. Pretreatment with either 25 or 40 mg/ kg of deprenyl did not significantly alter the magnitude of this depletion. These results indicate that, unlike what is observed following MPTP, there is no protection afforded dopaminergic cells by deprenyl pretreatment in the methamphetamine model of parkinsonism.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01245358

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