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  • 1
    Electronic Resource
    Electronic Resource
    The effects of long term administration of dopamine on renal function in hypertensive patients (1973)
    Springer
    European journal of clinical pharmacology 6 (1973), S. 150-155 
    Details
    ISSN: 1432-1041
    Keywords: Dopamine ; renal blood flow ; hypertension ; renal failure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of an intravenous infusion of dopamine (0.5 to 1.25 µg/kg/min) for periods of between 36 and 105h has been studied in eight patients with hypertension and varying degrees of renal impairment. There was a significant rise in the glomerular filtration rate (GFR) from 31.2±20.2 to 42.8±26.8 ml/min (p〈.05) after four hours of the infusion but after 48 h of infusion the mean GFR was no different from the control value. The paraaminohippuric acid (PAH) clearance also rose from 129.8±115.4 ml/min to 173.1±164.3 ml/min (p〈0.05) after four hours of infusion, but like the GFR it was no different from control after 48 h of the infusion. The daily urine volumes increased significantly during the dopamine infusion from 2176.0±49.2 ml/day to 3809.0±118.8 ml/day (p〈0.002) but had returned to control values after 48 h of continuing dopamine infusion. Following the end of the infusion there was a significant reduction in the urine volume to 1213.0±195.0 ml/day (p〈0.001). There was a rise in sodium excretion during the dopamine infusion from 94.8±50.7 meq/day to 264.7±172.8 meq/day (p〈0.01) with a fall after the end of the infusion to 33.2±27.5 meq/day (p〈0.05). There was no change in the blood urea during the dopamine infusion but after stopping the infusion the blood urea rose from 83.5±39.4 mg% to 95.1±39.0 mg% (p〈0.02). We conclude that intravenous infusion of dopamine to patients with hypertension and renal impairment may produce initial clinical improvement but is of little therapeutic benefit when given for prolonged periods.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558278
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The effect of dopamine on renal blood flow in man (1971)
    Springer
    European journal of clinical pharmacology 3 (1971), S. 131-136 
    Details
    ISSN: 1432-1041
    Keywords: Dopamine ; renal blood flow ; indicator dilution technique
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary 1. The effect of dopamine on renal blood flow as measured directly by an indicator dilution technique has been studied in eleven hypertensive patients. — 2. Dopamine (1 and 2 µg/kg body wt/min) caused a mean increase of 77.1% and 121.6% respectively in renal blood flow. This was four to five times greater than the corresponding change produced in cardiac output (+16.8% and +37% respectively over control values). — Neither propranolol (2 studies) nor phentolamine (1 study) blocked these changes in renal blood flow. — 4. Dopamine 2 µg/kg body wt/min caused a mean increase in sodium excretion from 0.269±0.246 mequiv/min to 0.942±0.429 mequiv/min in 4 hypertensive subjects. There was also an increase in glomerular filtration rate, measured by inulin clearance, from 95.2±13.8 ml/min to 124.7±13.4 ml/min and in effective renal blood flow measured by PAH clearance from 490.2±170.8ml/min to 673.0±256.2 ml/min.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00572452
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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