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  • Doxepin  (1)
  • Imipramine  (1)
  • acetylator phenotype  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Psychopharmacology 95 (1988), S. 63-67 
    ISSN: 1432-2072
    Keywords: Doxepin ; Imipramine ; Steady state ; Kinetics ; Interethnic difference
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The pharmacokinetics of doxepin (DX) was studied in 21 Saudi patients treated long term with oral doses of this tricyclic antidepressant agent. The mean (SEM) values of the dose-normalized steady-state concentration and the apparent clearance after oral administration of this drug were 25.8 (4.8) ng·ml-1/mg·kg-1 and 2.529 (0.342) l·h-1·kg-1, respectively. The pharmacokinetics of impramine (IMI) was also studied in 30 Saudi patients who received oral doses of this drug for long durations. The mean dose-normalized steady-state concentration of IMI was 68.3 (19.7) ng·ml-1/mg·kg-1, and the mean apparent clearance after oral administration of IMI was 1.619 (0.353) l·h-1·kg-1. The mean (SEM) ratio of the steady-state concentration of the metabolite desipramine (DES) to that of IMI (DES/IMI) was 0.873 (0.151). Using this value and the ratio of the mean apparent clearance after oral administration (TCL) of DES to that of IMI, the fraction of IMI metabolized to DES was calculated to be 0.489. The TCL of DES was estimated from data obtained for three additional patients who received oral doses of this drug for long durations. A mean value of 0.907 (0.351) l·h-1·kg-1 was obtained.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-904X
    Keywords: drug monitoring ; tuberculosis ; microsamples ; acetylator phenotype ; metabolites ; liquid chromatography ; dual detection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract A rapid liquid chromatographic method for simultaneous determination of isoniazid (INH), acetylisoniazid (AINH), rifampin (RIF), and deacetylrifampin (DARIF) in microsamples of deproteinized plasma is described. The compounds and internal standard (IS) (diphenylcarbazide) were separated on a 10-µm, 8 mm × 10-cm phenyl Radial Pak cartridge in conjunction with a binary linear gradient system at a flow rate of 3 ml/min. A dual electrochemical (+ 800 mV) and Spectrophotometric (334 nm) detection system with a computerized data station was employed to measure the above compounds in the effluent. Prior to injection, the plasma sample was diluted (2:1) with a pH 3, 0.075 M phosphate buffer after adding the internal standard (6.67 µg/ml of plasma) and passed through an Amicon Centrifree-MS filter at 2000g. Under these conditions, no interference in the analysis was observed, and the retention times of AINH, INH, IS, DARIF, and RIF were 3.95, 4.89, 15.82, 17.25, and 19.34 min, respectively. The linearity of the assay for all four compounds was excellent (r 〉 0.9925), and the between- and within-day CV was not 〉8% at any concentration. This method is currently being used for therapeutic monitoring and pharmacokinetic studies of INH, RIF, and their major metabolites in patients with tuberculosis.
    Type of Medium: Electronic Resource
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